Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Francesca Copperi"'
Autor:
Francesca Copperi, Inna Schleis, Martin Roumain, Giulio G. Muccioli, Stefano Casola, Martin Klingenspor, Alexander Pfeifer, Thorsten Gnad
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Francesca Copperi et al. evaluate the role of the Gi-protein coupled receptor, EBI2, on regulation of thermogenic activity in murine and human adipocytes. They report that loss of Ebi2 in mice increases brown adipocyte energy expenditure in response
Externí odkaz:
https://doaj.org/article/38c7ef6bb2f0416ea97ba86de74291a0
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Increasing evidence indicates that the melanocortin system is not only a central player in energy homeostasis, food intake and glucose level regulation, but also in the modulation of cardiovascular functions, such as blood pressure and heart rate. Th
Externí odkaz:
https://doaj.org/article/d18ec2cf20ae42f3bbaa7215770d70a4
Autor:
Carlo C. Campa, Rangel L. Silva, Jean P. Margaria, Tracey Pirali, Matheus S. Mattos, Lucas R. Kraemer, Diego C. Reis, Giorgio Grosa, Francesca Copperi, Eduardo M. Dalmarco, Roberto C. P. Lima-Júnior, Silvio Aprile, Valentina Sala, Federica Dal Bello, Douglas Silva Prado, Jose Carlos Alves-Filho, Claudio Medana, Geovanni D. Cassali, Gian Cesare Tron, Mauro M. Teixeira, Elisa Ciraolo, Remo C. Russo, Emilio Hirsch
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Activation of PI3K plays a role in pulmonary inflammation. Here, the authors develop a drug inhibitor of PI3K, and show that it inhibits lung inflammation and damage in mouse models of asthma and lung fibrosis.
Externí odkaz:
https://doaj.org/article/ffd766e4bb69453a8c45e742f2d6dd75
Autor:
Francesca, Copperi, Inna, Schleis, Martin, Roumain, Giulio G, Muccioli, Stefano, Casola, Martin, Klingenspor, Alexander, Pfeifer, Thorsten, Gnad
Publikováno v:
Communications biology, Vol. 5, no.1, p. 280 [1-9] (2022)
Pharmacological activation of brown adipose tissue (BAT) is an attractive approach for increasing energy expenditure to counteract obesity. Given the side-effects of known activators of BAT, we studied inhibitors of BAT as a novel, alternative concep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7486c765b04b61b9dd969065afc6b9f8
https://hdl.handle.net/2078.1/262732
https://hdl.handle.net/2078.1/262732
Publikováno v:
Biol Psychiatry
Obesity and mood disorders are often overlapping pathologies that are prevalent public health concerns. Many studies have indicated a positive correlation between depression and obesity, although weight loss and decreased appetite are also recognized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3a4fff6731227fba9675700b0e9eef
https://europepmc.org/articles/PMC8643363/
https://europepmc.org/articles/PMC8643363/
Autor:
Thorsten Gnad, Gemma Navarro, Minna Lahesmaa, Laia Reverte-Salisa, Francesca Copperi, Arnau Cordomi, Jennifer Naumann, Aileen Hochhäuser, Saskia Haufs-Brusberg, Daniela Wenzel, Frank Suhr, Naja Zenius Jespersen, Camilla Scheele, Volodymyr Tsvilovskyy, Christian Brinkmann, Joern Rittweger, Christian Dani, Mathias Kranz, Winnie Deuther-Conrad, Holger K. Eltzschig, Tarja Niemi, Markku Taittonen, Peter Brust, Pirjo Nuutila, Leonardo Pardo, Bernd K. Fleischmann, Matthias Blüher, Rafael Franco, Wilhelm Bloch, Kirsi A. Virtanen, Alexander Pfeifer
Publikováno v:
Cell Metabolism. 34:649
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88374ca60195ccaeb99d40f2e4d656b7
https://doi.org/10.1016/j.cmet.2022.02.014
https://doi.org/10.1016/j.cmet.2022.02.014
Autor:
Maria Chiara De Santis, Carlo Cosimo Campa, Emilio Hirsch, Carla Bosia, Abhishek Derle, Marco Del Giudice, Jean Piero Margaria, Luca Gozzelino, Francesca Copperi
Publikováno v:
Nature Chemical Biology. 14:801-810
Directional transport of recycling cargo from early endosomes (EE) to the endocytic recycling compartment (ERC) relies on phosphatidylinositol 3-phosphate (PtdIns(3)P) hydrolysis and activation of the small GTPase Rab11. However, how these events are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ad5b41efd787867d3676b10902c44e
https://doi.org/10.1038/s41589-018-0086-4
https://doi.org/10.1038/s41589-018-0086-4
Autor:
Aileen Hochhäuser, Camilla Scheele, Christian Dani, Thorsten Gnad, Frank Suhr, Saskia Haufs-Brusberg, Volodymyr Tsvilovskyy, Peter Brust, Arnau Cordomí, Minna Lahesmaa, Wilhelm Bloch, Markku Taittonen, Matthias Blüher, Mathias Kranz, Leonardo Pardo, Daniela Wenzel, Holger K. Eltzschig, Laia Reverte-Salisa, Francesca Copperi, Alexander Pfeifer, Gemma Navarro, Rafael Franco, Tarja Niemi, Jennifer Naumann, Pirjo Nuutila, Winnie Deuther-Conrad, Christian Brinkmann, Bernd K. Fleischmann, Naja Z. Jespersen, Joern Rittweger, Kirsi A. Virtanen
Publikováno v:
Cell Metabolism 32(2020), 56-70
Cell Metab
Cell Metab
The combination of aging populations with the obesity pandemic results in an alarming rise in non-communicable diseases. Here, we show that the enigmatic adenosine A2B receptor (A2B) is abundantly expressed in skeletal muscle (SKM) as well as brown a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb665cfbd6acb786b99d1d0a1200a0b7
https://doi.org/10.1016/j.cmet.2020.06.006
https://doi.org/10.1016/j.cmet.2020.06.006
Autor:
Valentina Sala, Diego Carlos dos Reis, Eduardo Monguilhott Dalmarco, Mauro M. Teixeira, Emilio Hirsch, Gian Cesare Tron, Federica Dal Bello, Giorgio Grosa, Jean Piero Margaria, Geovanni Dantas Cassali, Roberto C. P. Lima-Júnior, Lucas Kraemer, Francesca Copperi, Remo Castro Russo, Carlo Cosimo Campa, Claudio Medana, Douglas Silva Prado, José C. Alves-Filho, Matheus Silvério Mattos, Elisa Ciraolo, Silvio Aprile, Tracey Pirali, Rangel L. Silva
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PI3K activation plays a central role in the development of pulmonary inflammation and tissue remodeling. PI3K inhibitors may thus offer an improved therapeutic opportunity to treat non-resolving lung inflammation but their action is limited by unwant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5904eb2e0477593cf9fc48dc115e459
https://pubmed.ncbi.nlm.nih.gov/30542075
https://pubmed.ncbi.nlm.nih.gov/30542075
Autor:
Giulia Germena, Christoph Scheiermann, Irene Franco, Andrea Antonio Gamba, Augusta Di Savino, Alessandra Ghigo, Remco T. A. Megens, Emilio Hirsch, Francesca Copperi, Markus Sperandio, Angela R.M. Kurz, Miriam Martini, Anna Sapienza, Alessia Perino, Elisa Ciraolo, Carlo Cosimo Campa, Annalisa Camporeale
Publikováno v:
Science Signaling, Vol. 9, No 459 (2016) P. ra124
Science Signaling, 9(459):ra124. American Association for the Advancement of Science
Science Signaling, 9(459):ra124. American Association for the Advancement of Science
Mobilization of neutrophils from the bone marrow determines neutrophil blood counts and thus is medically important. Balanced neutrophil mobilization from the bone marrow depends on the retention-promoting chemokine CXCL12 and its receptor CXCR4 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34578d9dc194677a1f9bb626e66ac41e
http://hdl.handle.net/11583/2670814
http://hdl.handle.net/11583/2670814