Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Francesca Civoli"'
Autor:
Jenny Hu, Yanbin Yu, Hong Han, Francesca Civoli, Yao Zhuang, John Thomas, Steve Swanson, Shuqian Jing, Shalini Gupta
Publikováno v:
Cells, Vol 3, Iss 1, Pp 79-91 (2014)
BAFF has a critical role in B-cell survival, maturation and function, which makes its pathway a prime therapeutic target for various autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis and Sjögren’s syndrome. A ce
Externí odkaz:
https://doaj.org/article/dc5e74bbeb364f6dbd8629aadc73adbc
Autor:
Francesca Civoli, Barbara Finck, Helen Tang, Jennifer Hodge, Hillary O’Kelly, Vladimir Vexler
Publikováno v:
Advances in Therapy. 39:1230-1246
Biologic therapeutics can trigger immune responses in patients. As part of the totality of evidence that is required for regulatory approval of biosimilars, immunogenicity similarity must be assessed in the clinical programs. Pegfilgrastim-cbqv (UDEN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba756d9d42a0504515dd64f1aa9943c
https://doi.org/10.1007/s12325-021-02024-x
https://doi.org/10.1007/s12325-021-02024-x
Autor:
Hong Tang, Francesca Civoli, Suzanna Tatarewicz, Lisa Miyasaki, Hillary O'Kelly, Alasdair Young, Barbara Finck
Publikováno v:
Journal of Clinical Oncology. 40:e18637-e18637
e18637 Background: Pegfilgrastim-cbqv, a pegfilgrastim biosimilar, is administered 24-72 h after myelosuppressive chemotherapy to prevent febrile neutropenia. Pegfilgrastim delivery via an on-body injector (OBI) applied on the day of chemotherapy eli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e897d4e35504a7d3f21e3251799c1373
https://doi.org/10.1200/jco.2022.40.16_suppl.e18637
https://doi.org/10.1200/jco.2022.40.16_suppl.e18637
Autor:
John Chappell, Shannon Rebarchak, Joseph C. Marini, Gregor Schaffar, Andrew Exley, Ronald R. Bowsher, Viswanath Devanarayan, Francesca Civoli, Aparna Kasinath, Vera Koppenburg, Xiao-Yan Cai, Michael Anderson, Philip Oldfield, Meenu Wadhwa, S. Alvandkouhi, Todd Lester
Publikováno v:
The AAPS journal. 22(1)
For biosimilar drug development programs, it is essential to demonstrate that there are no clinically significant differences between the proposed biosimilar therapeutic (biosimilar) and its reference product (originator). Based on a stepwise compreh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f652a092dc19db1331fed18e13d493
https://pubmed.ncbi.nlm.nih.gov/31792633
https://pubmed.ncbi.nlm.nih.gov/31792633
Autor:
Stephanie Grauer, Chadwick King, Jilin Sun, Steven J. Swanson, Troy E. Barger, Daniel T. Mytych, Andrew J. Kuck, Mukta Shiwalkar, Raj Haldankar, Eric Hsu, Sergio Sanchez, Francesca Civoli, Michelle Wu
Publikováno v:
Journal of Immunological Methods. 382:129-141
Recombinant human erythropoietin (EPO) has been used therapeutically for more than two decades in the treatment of anemia. Although EPO is generally well tolerated, in rare cases, patients have developed anti-EPO antibodies that can negatively impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9f05686c7647abefe186ded83cd17b
https://doi.org/10.1016/j.jim.2012.05.013
https://doi.org/10.1016/j.jim.2012.05.013
Autor:
Sergio Sanchez, Lei Zhou, Steven J. Swanson, M. D. Hale, Francesca Civoli, Daniel T. Mytych, Shalini Gupta, Troy E. Barger
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 55:1265-1274
Functional cell-based assays are the preferred method to test for the presence of anti-rHuEPO neutralizing antibodies (NAbs). However, due to the unpredictable nature of test serum matrix effects on cell-based assays, confirmatory assays are essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98384ed2cf646dbd031e1caa765da5d2
https://doi.org/10.1016/j.jpba.2011.03.029
https://doi.org/10.1016/j.jpba.2011.03.029
Autor:
Janice Nagatani, Francesca Civoli, Yao Zhuang, Iwona Wala, Arunan Kaliyaperumal, Hong Han, Troy E. Barger, Jenny Hu, Shalini Gupta
Publikováno v:
Journal of immunological methods. 419
Anti-drug neutralizing antibodies (NAbs) formed due to unwanted immunogenicity of a therapeutic protein point towards a mature immune response. NAb detection is important in interpreting the therapeutic's efficacy and safety in vivo. In vitro cell-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffb275117e7b9e59b87ce226465a4f4
https://pubmed.ncbi.nlm.nih.gov/25795420
https://pubmed.ncbi.nlm.nih.gov/25795420
Autor:
Francesca Civoli, Larry W. Daniel
Publikováno v:
Cancer Chemotherapy and Pharmacology. 42:319-326
Purpose: ET-18-OCH3 (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) is a representative of the first generation of antitumor ether lipids and is a model in the development of new compounds including a series of quaternary ammonium analogs (QA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607f6c6871814f75688db004e36e6004
https://doi.org/10.1007/s002800050824
https://doi.org/10.1007/s002800050824
Autor:
Chris Morrow, David Rusnak, Holger Pils, Francesca Civoli, John Derent, Ago B. Ahene, Kinnari Pandya, Susan Spitz, Joel Usansky, Brian Sue, Daniel Leach
Publikováno v:
The AAPS journal. 14(1)
A constant demand in the pharmaceutical industry is to accomplish more with the same or fewer resources. It is generally accepted that a major expense of an established laboratory is the personnel, which constitutes a fixed cost. Improving the effici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d24fa4df3d0d7c18be333d4e63421c8
https://pubmed.ncbi.nlm.nih.gov/22302584
https://pubmed.ncbi.nlm.nih.gov/22302584
Publikováno v:
Drug discovery today. 8(17)
G-protein-coupled receptors (GPCRs) are the most successful target proteins for drug discovery research to date. More than 150 orphan GPCRs of potential therapeutic interest have been identified for which no activating ligands or biological functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188abc556fa3a7f61643fd74a1286a17
https://pubmed.ncbi.nlm.nih.gov/12946641
https://pubmed.ncbi.nlm.nih.gov/12946641