Výsledky vyhledávání - "Francesca Chamian"

Blockade of CD11a by Efalizumab in Psoriasis Patients Induces a Unique State of T-Cell Hyporesponsiveness

Autor: Yulia Vugmeyster, Francesca Chamian, Edmund Lee, Toyoko Kikuchi, Wolfgang Dummer, Kathy Howell, Michelle A. Lowes, Emma Guttman-Yassky, James G. Krueger, Sarah C. Bodary, Brisdell Hunte, Patricia Gilleaudeau, Mark Kagen

Publikováno v: Journal of Investigative Dermatology. 128(5):1182-1191

Efalizumab (anti-CD11a) interferes with LFA-1/ICAM-1 binding and inhibits several key steps in psoriasis pathogenesis. This study characterizes the effects of efalizumab on T-cell activation responses and expression of surface markers on human circul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3652113ef59e5ff50331fef60529df1

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Novel Insight into the Agonistic Mechanism of Alefacept In Vivo: Differentially Expressed Genes May Serve as Biomarkers of Response in Psoriasis Patients

Autor: Asifa Haider, Irma Cardinale, Kamruz Darabi, Raj Bandaru, Michelle A. Lowes, James G. Krueger, Inna Novitskaya, Francesca Chamian, Humphrey Gardner, Patricia Gilleaudeau, Mary S. Whalen, Toyoko Kikuchi

Publikováno v: The Journal of Immunology. 178:7442-7449

Alefacept is an LFA3-Ig fusion protein that binds to CD2 and is thought to inhibit T cell activation by antagonism of CD2 signaling or by lysis of CD2+ cells. Alefacept is potential future therapeutic for organ transplant recipients or graft-vs-host

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbc90be4e851304ee19f357a0a3e1c0
https://doi.org/10.4049/jimmunol.178.11.7442

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Prominent Production of IL-20 by CD68+/CD11c+ Myeloid-Derived Cells in Psoriasis: Gene Regulation and Cellular Effects

Autor: Edmund Lee, Michelle A. Lowes, Judilyn Fuentes-Duculan, Frank Wang, Irma Cardinale, Asifa Haider, Francesca Chamian, James G. Krueger, Maria Veronica Abello

Publikováno v: Journal of Investigative Dermatology. 126(7):1590-1599

We assessed expression of IL-20 and its receptors in psoriasis, given the recent implication of IL-20 in epidermal hyperplasia. Psoriatic lesional (LS) skin consistently expressed more IL-20 mRNA than nonlesional (NL) skin. Immunoreactivity to IL-20

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Efalizumab (anti-CD11a)-induced increase in peripheral blood leukocytes in psoriasis patients is preferentially mediated by altered trafficking of memory CD8+ T cells into lesional skin*1

Autor: Sarah C. Bodary, James G. Krueger, Patricia Gilleaudeau, Yulia Vugmeyster, Michelle A. Lowes, Francesca Chamian, Edmund Lee, Kathy Howell, Toyoko Kikuchi, Wolfgang Dummer, Mark Kagen

Publikováno v: Clinical Immunology. 113:38-46

Therapeutic administration of efalizumab, a humanized antibody to CD11a, induces a marked but reversible increase of peripheral lymphocytes in psoriasis patients. In this study, 13 patients were treated with 12 weekly subcutaneous doses (2 mg/kg/week

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a8e48c96e795c3d6a3fd1add9677ce5
https://doi.org/10.1016/j.clim.2004.06.001

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Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris

Autor: Francesca Chamian, James G. Krueger, Madhav V. Dhodapkar, Frank Wang, Judith L. Oestreicher, William L. Trepicchio, Edmund Lee, Debra D. Pittman

Publikováno v: The Journal of Experimental Medicine

Psoriasis is a type I–deviated disease characterized by the presence of interferon (IFN)-γ and multiple IFN-related inflammatory genes in lesions. Because interleukin (IL)-23 is now recognized to play a role in the recruitment of inflammatory cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61529ea71a0d2eedc679083b644b23b6
https://doi.org/10.1084/jem.20030451

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Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series

Autor: Kim A. Papp, Craig L. Leonardi, Francesca Chamian, James G. Krueger, Wolfgang Dummer, Michelle A. Lowes, Maria Veronica Abello

Publikováno v: BMC Dermatology, Vol 7, Iss 1, p 2 (2007)
BMC Dermatology

Background Newer biological therapies for moderate-to-severe psoriasis are being used more frequently, but unexpected effects may occur. Case presentations We present a group of 15 patients who developed inflammatory papules while on efalizumab thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c8c2c38e543e77b8a23e52b767b2f8
http://www.biomedcentral.com/1471-5945/7/2

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Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

Autor: Judilyn Fuentes-Duculan, Francesca Chamian, Mary Sullivan-Whalen, Patricia Gilleaudeau, Inna Novitskaya, Michelle A. Lowes, Toyoko Kikuchi, Rachel Nussbaum, Marvin Garovoy, Wolfgang Dummer, Maria Veronica Abello, Shao Lee Lin, Henrietta Carbonaro, Irma Cardinale, Ralph M. Steinman, James G. Krueger, Knut M. Wittkowski, Kim A. Papp

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 102(52)

We find that CD11c + cells with many markers of dendritic cells (DCs) are a major cell type in the skin lesions of psoriasis. These CD11c + cells, which are evident in both epidermis and dermis, are the sites for the expression of two mediators of in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4c1ae42637ef1bc35d97b54cedf5c0
https://pubmed.ncbi.nlm.nih.gov/16380428

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TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques

Autor: Melissa Magliocco, Francesca Chamian, James G. Krueger, Alice B. Gottlieb, Maria Veronica Abello, Irma Cardinale, Michelle A. Lowes, Fei Chen, Salman Masud

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 175(4)

The mechanisms of action of marketed TNF-blocking drugs in lesional tissues are still incompletely understood. Because psoriasis plaques are accessible to repeat biopsy, the effect of TNF/lymphotoxin blockade with etanercept (soluble TNFR) was studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a70889ec19d59105e8ab7ccba80d73
https://pubmed.ncbi.nlm.nih.gov/16081850

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Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris

Autor: James G. Krueger, Patricia Gilleaudeau, Irma Cardinale, Artemis Khatcherian, Toyoko Kikuchi, Inna Novitskaya, Edmund Lee, Michelle A. Lowes, Knut M. Wittkowski, Francesca Chamian, Shao-Lee Lin, Mary Sullivan-Whalen

Psoriasis vulgaris, a skin disease that is considered to be the result of a type 1 autoimmune response, provides an opportunity for studying the changes that occur in a target-diseased tissue during innovative immunotherapies. To gain a more comprehe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d974f14b6c49328dbd88c531e75e827
https://europepmc.org/articles/PMC545584/

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