Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Francesca Cendali"'
Autor:
Meng-Han Wu, Felipe Valenca-Pereira, Francesca Cendali, Emily L. Giddings, Catherine Pham-Danis, Michael C. Yarnell, Amanda J. Novak, Tonya M. Brunetti, Scott B. Thompson, Jorge Henao-Mejia, Richard A. Flavell, Angelo D’Alessandro, M. Eric Kohler, Mercedes Rincon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Mitochondrial respiration is essential for the survival and function of T cells used in adoptive cellular therapies. However, strategies that specifically enhance mitochondrial respiration to promote T cell function remain limited. Here, we
Externí odkaz:
https://doaj.org/article/d0884f5a1b81480bad4290e7a5d667fa
Autor:
Travis Nemkov, Francesca Cendali, Monika Dzieciatkowska, Daniel Stephenson, Kirk C. Hansen, Catherine M. Jankowski, Angelo D’Alessandro, Ryan J. Marker
Publikováno v:
Pathophysiology, Vol 31, Iss 1, Pp 166-182 (2024)
To molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic ductal adenocarcinoma (PDAC) patients, a multi-omics approach was employed for the analysis of plasma samples before a
Externí odkaz:
https://doaj.org/article/0b0186f221ec4f63b83ecbe9bbe07658
Autor:
Angelo D’Alessandro, S. Mehdi Nouraie, Yingze Zhang, Francesca Cendali, Fabia Gamboni, Julie A. Reisz, Xu Zhang, Kyle W. Bartsch, Matthew D. Galbraith, Joaquin M. Espinosa, Victor R. Gordeuk, Mark T. Gladwin
Publikováno v:
Haematologica, Vol 108, Iss 12 (2023)
Metabolomics studies in sickle cell disease (SCD) have been so far limited to tens of samples, owing to technical and experimental limitations. To overcome these limitations, we performed plasma metabolomics analyses on 596 samples from patients with
Externí odkaz:
https://doaj.org/article/13b00fe65b484a3b819623eae10a6dc7
Autor:
Christina Lisk, Francesca Cendali, David I. Pak, Delaney Swindle, Kathryn Hassell, Rachelle Nuss, Gemlyn George, Pavel Davizon-Castillo, Paul W. Buehler, Angelo D’Alessandro, David C. Irwin
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionHuman and murine sickle cell disease (SCD) associated pulmonary hypertension (PH) is defined by hemolysis, nitric oxide depletion, inflammation, and thrombosis. Further, hemoglobin (Hb), heme, and iron accumulation are consistently observ
Externí odkaz:
https://doaj.org/article/2b14caf86c4044b991f1322159efd216
Autor:
Kiruphagaran Thangaraju, Upendra Katneni, Imo J. Akpan, Kenichi Tanaka, Tiffany Thomas, Saini Setua, Julie A. Reisz, Francesca Cendali, Fabia Gamboni, Travis Nemkov, Stacie Kahn, Alexander Z. Wei, Jacob E. Valk, Krystalyn E. Hudson, David J. Roh, Chiara Moriconi, James C. Zimring, Angelo D'Alessandro, Steven L. Spitalnik, Richard O. Francis, Paul W. Buehler
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
Aging and obesity independently contribute toward an endothelial dysfunction that results in an imbalanced VWF to ADAMTS13 ratio. In addition, plasma thrombin and plasmin generation are elevated and reduced, respectively, with increasing age and also
Externí odkaz:
https://doaj.org/article/b551da122a624fafad94df464e4f7a0a
Autor:
Micaela K. Roy, Francesca Cendali, Gabrielle Ooyama, Fabia Gamboni, Holmes Morton, Angelo D’Alessandro
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Background: Pyruvate kinase deficiency (PKD) is the most frequent congenital enzymatic defect of glycolysis, and one of the most common causes of hereditary non spherocytic hemolytic anemia. Therapeutic interventions are limited, in part because of t
Externí odkaz:
https://doaj.org/article/8f34c2691c5a46328dce557380454aac
Autor:
Killian Donovan, Athinoula Meli, Francesca Cendali, Kyung Chan Park, Rebecca Cardigan, Simon Stanworth, Stuart McKechnie, Angelo D’Alessandro, Peter A. Smethurst, Pawel Swietach
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/c6e7b3b938224a8d8cb46474afd09acd
Autor:
Jacqueline A. Turner, Emily L. Paton, Robert Van Gulick, Davide Stefanoni, Francesca Cendali, Julie Reisz, Richard P. Tobin, Martin McCarter, Angelo D’Alessandro, Raul M. Torres, William A. Robinson, Kasey L. Couts, Isabel R. Schlaepfer
Publikováno v:
Cancers, Vol 14, Iss 9, p 2110 (2022)
There is increasing evidence that oxidative metabolism and fatty acids play an important role in BRAF-driven tumorigenesis, yet the effect of BRAF mutation and expression on metabolism is poorly understood. We examined how BRAF mutation and expressio
Externí odkaz:
https://doaj.org/article/49d0738444c341358885900619d4717e
Autor:
Vassilis L. Tzounakas, Alkmini T. Anastasiadi, Davide Stefanoni, Francesca Cendali, Lorenzo Bertolone, Fabia Gamboni, Monika Dzieciatkowska, Pantelis Rousakis, Athina Vergaki, Vassilis Soulakis, Ourania E. Tsitsilonis, Konstantinos Stamoulis, Issidora S. Papassideri, Anastasios G. Kriebardis, Angelo D’Alessandro, Marianna H. Antonelou
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
Blood donor genetics and lifestyle affect the quality of red blood cell (RBC) storage. Heterozygotes for beta thalassemia (bThal+) constitute a non-negligible proportion of blood donors in the Mediterranean and other geographical areas. The unique he
Externí odkaz:
https://doaj.org/article/a140ed31f5bb436bba49fef80e264f1a
Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling
Autor:
Travis Nemkov, Sarah C. Skinner, Elie Nader, Davide Stefanoni, Mélanie Robert, Francesca Cendali, Emeric Stauffer, Agnes Cibiel, Camille Boisson, Philippe Connes, Angelo D’Alessandro
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 896 (2021)
Here we describe the effects of a controlled, 30 min, high-intensity cycling test on blood rheology and the metabolic profiles of red blood cells (RBCs) and plasma from well-trained males. RBCs demonstrated decreased deformability and trended toward
Externí odkaz:
https://doaj.org/article/8b0f8405c53740e1bc0c7cff5bb3873a