Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Francesca Cantini"'
Autor:
Alessia De Santis, Deborah Grifagni, Andrea Orsetti, Elena Lenci, Antonio Rosato, Mariapina D’Onofrio, Andrea Trabocchi, Simone Ciofi-Baffoni, Francesca Cantini, Vito Calderone
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1260 (2024)
The conservation of the main protease in viral genomes, combined with the absence of a homologous protease in humans, makes this enzyme family an ideal target for developing broad-spectrum antiviral drugs with minimized host toxicity. GC-376, a pepti
Externí odkaz:
https://doaj.org/article/e9ef22ae83444f268486edbe5fa60502
Autor:
Elisa Bianconi, Anna Gidari, Maria Souma, Samuele Sabbatini, Deborah Grifagni, Carlo Bigiotti, Elisabetta Schiaroli, Lucia Comez, Alessandro Paciaroni, Francesca Cantini, Daniela Francisci, Antonio Macchiarulo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Non-structural protein 5 (Nsp5) is a cysteine protease that plays a key role in SARS-CoV-2 replication, suppressing host protein synthesis and promoting immune evasion. The investigation of natural products as a potential strategy for Nsp5 inhibition
Externí odkaz:
https://doaj.org/article/9cb6c05eee4a4813a77d76c7d39b0a1b
Autor:
Francesca Cantini, Paola Giannì, Sara Bobone, Cassandra Troiano, Hugo van Ingen, Renato Massoud, Nicoletta Perini, Luciana Migliore, Philippe Savarin, Charles Sanders, Lorenzo Stella, Marco Sette
Publikováno v:
Membranes, Vol 13, Iss 3, p 365 (2023)
(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabroli
Externí odkaz:
https://doaj.org/article/ebc10c2dbfd54507a807bb77133d0833
Autor:
Leonardo Querci, Inês B. Trindade, Michele Invernici, José Malanho Silva, Francesca Cantini, Ricardo O. Louro, Mario Piccioli
Publikováno v:
Magnetochemistry, Vol 9, Iss 3, p 66 (2023)
In paramagnetic metalloproteins, longitudinal relaxation rates of 13C′ and 13Cα nuclei can be measured using 13C detected experiments and converted into electron spin-nuclear spin distance restraints, also known as Paramagnetic Relaxation Enhancem
Externí odkaz:
https://doaj.org/article/b6d79f28072a46418798e14b434b59c7
Autor:
Lara Massai, Deborah Grifagni, Alessia De Santis, Andrea Geri, Francesca Cantini, Vito Calderone, Lucia Banci, Luigi Messori
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1675 (2022)
Gold compounds have a long tradition in medicine and offer many opportunities for new therapeutic applications. Herein, we evaluated the lead compound Auranofin and five related gold(I) complexes as possible inhibitors of SARS-CoV-2 Main Protease (SA
Externí odkaz:
https://doaj.org/article/a3ea0616ea5a4d1899af8596752ff674
Autor:
Francesca Cantini, Emanuele Andreano, Ida Paciello, Veronica Ghini, Francesco Berti, Rino Rappuoli, Lucia Banci
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 1981 (2022)
The higher-order structure (HOS) of protein therapeutics has been confirmed as a critical quality parameter. In this study, we compared 2D 1H-13C ALSOFAST-HMQC NMR spectra with immunochemical ELISA-based analysis to evaluate their sensitivity in asse
Externí odkaz:
https://doaj.org/article/226ecd17b12e421781c070bfbaac9012
Publikováno v:
Bio-Protocol, Vol 10, Iss 20 (2020)
This protocol illustrates the modelling of a protein-peptide complex using the synergic combination of in silico analysis and experimental results. To this end, we use the integrative modelling software HADDOCK, which possesses the powerful ability t
Externí odkaz:
https://doaj.org/article/1af2eb004c4e43c687ba61168becaa84
Autor:
Andrea Saponaro, Francesca Cantini, Alessandro Porro, Annalisa Bucchi, Dario DiFrancesco, Vincenzo Maione, Chiara Donadoni, Bianca Introini, Pietro Mesirca, Matteo E Mangoni, Gerhard Thiel, Lucia Banci, Bina Santoro, Anna Moroni
Publikováno v:
eLife, Vol 7 (2018)
Binding of TRIP8b to the cyclic nucleotide binding domain (CNBD) of mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels prevents their regulation by cAMP. Since TRIP8b is expressed exclusively in the brain, we envisage that i
Externí odkaz:
https://doaj.org/article/87a2647ccdde4fd198fde82c0b16162e
Autor:
Alessia Liguori, Enrico Malito, Paola Lo Surdo, Luca Fagnocchi, Francesca Cantini, Andreas F Haag, Sébastien Brier, Mariagrazia Pizza, Isabel Delany, Matthew J Bottomley
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005557 (2016)
Neisseria adhesin A (NadA) is present on the meningococcal surface and contributes to adhesion to and invasion of human cells. NadA is also one of three recombinant antigens in the recently-approved Bexsero vaccine, which protects against serogroup B
Externí odkaz:
https://doaj.org/article/fe26d987d2f647f6a06de8fb4b7f80d5
Autor:
Valeria Cafardi, Massimiliano Biagini, Manuele Martinelli, Rosanna Leuzzi, Jeffrey T Rubino, Francesca Cantini, Nathalie Norais, Maria Scarselli, Davide Serruto, Meera Unnikrishnan
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81306 (2013)
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known. Also, apart from the toxins, protein
Externí odkaz:
https://doaj.org/article/e50033621e1b4a3f838d828e1dd5730f