Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Francesca Blasco"'
Autor:
Suresh B Lakshminarayana, Helena I M Boshoff, Joseph Cherian, Sindhu Ravindran, Anne Goh, Jan Jiricek, Mahesh Nanjundappa, Amit Nayyar, Meera Gurumurthy, Ramandeep Singh, Thomas Dick, Francesca Blasco, Clifton E Barry, Paul C Ho, Ujjini H Manjunatha
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105222 (2014)
PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during
Externí odkaz:
https://doaj.org/article/7f9d4e061d1d44e1bb837ce762cb14e3
Autor:
Robin A. Fairhurst, Pascal Furet, Patricia Imbach-Weese, Frédéric Stauffer, Heinrich Rueeger, Clive McCarthy, Sebastien Ripoche, Susanne Oswald, Bertrand Arnaud, Aline Jary, Michel Maira, Christian Schnell, Daniel A. Guthy, Markus Wartmann, Michael Kiffe, Sandrine Desrayaud, Francesca Blasco, Toni Widmer, Frank Seiler, Sascha Gutmann, Mark Knapp, Giorgio Caravatti
Publikováno v:
Journal of Medicinal Chemistry. 65:8345-8379
Balanced pan-class I phosphoinositide 3-kinase inhibition as an approach to cancer treatment offers the prospect of treating a broad range of tumor types and/or a way to achieve greater efficacy with a single inhibitor. Taking buparlisib as the start
Autor:
Thomas Radimerski, Francesco Hofmann, Lorenza Wyder, Markus Wartmann, Eric Vangrevelinghe, Joerg Trappe, Stephan Ruetz, Lynda Nolan, David Ledieu, Marc Lang, Marc Gerspacher, Pascal Furet, Dirk Erdmann, Peter Drueckes, Patrick Chène, Josef Brueggen, Francesca Blasco, Gisele A. Tavares, Carole Pissot-Soldermann, Alain De Pover, Catherine H. Régnier, Fabienne Baffert
The recent discovery of an acquired activating point mutation in JAK2, substituting valine at amino acid position 617 for phenylalanine, has greatly improved our understanding of the molecular mechanism underlying chronic myeloproliferative neoplasms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7997e164cd9af3cf9ffb6c692aca1cec
https://doi.org/10.1158/1535-7163.c.6531816
https://doi.org/10.1158/1535-7163.c.6531816
Autor:
Thomas Radimerski, Francesco Hofmann, Lorenza Wyder, Markus Wartmann, Eric Vangrevelinghe, Joerg Trappe, Stephan Ruetz, Lynda Nolan, David Ledieu, Marc Lang, Marc Gerspacher, Pascal Furet, Dirk Erdmann, Peter Drueckes, Patrick Chène, Josef Brueggen, Francesca Blasco, Gisele A. Tavares, Carole Pissot-Soldermann, Alain De Pover, Catherine H. Régnier, Fabienne Baffert
Supplementary Data from Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9b8ce3cdd08cb9653d9038e050b02d
https://doi.org/10.1158/1535-7163.22485180.v1
https://doi.org/10.1158/1535-7163.22485180.v1
Autor:
Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu
Publikováno v:
Science Translational Medicine. 13
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound library and identified candidate chemical inhibi
Autor:
Martijn Fenaux, Andrea Leonardi, Sreehari Babu, Peck Gee Seah, Wei Liu, Pei Yong Shi, Rao P S Srinivasa, Suresh B. Lakshminarayana, Haoying Xu, Jin Zhang, Fumiaki Yokokawa, Cheah Chen Seh, Francesca Blasco, Nahdiyah Abdul Ghafar, Wai Ling Chan, Gang Wang, Ellie Growcott, Feng Gu, Weidong Zhong, Keshi Wang, Mei Ding, Ratna Karuna, Siew Pheng Lim, Yen Liang Chen
Publikováno v:
Antimicrob Agents Chemother
Monophosphate prodrug analogs of 2′-deoxy-2′-fluoro-2′-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue virus activities in cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dd646098b1cf2a7e9cd9dd08f0a432
https://europepmc.org/articles/PMC7674056/
https://europepmc.org/articles/PMC7674056/
Autor:
Wei Liu, Sreehari Babu, Wai Ling Chan, Suresh B. Lakshminarayana, Ellena Growcott, Peck Gee Seah, Martijn Fenaux, Mei Ding, Nahdiyah Abdul Ghafar, Gang Wang, Ratna Karuna, Cheah Chen Seh, Haoying Xu, Feng Gu, Weidong Zhong, Pei Yong Shi, Keshi Wang, Andrea Leonardi, Francesca Blasco, Yen Liang Chen, Srinivasa P. S. Rao, Siew Pheng Lim, Fumiaki Yokokawa, Jin Zhang
Monophosphate prodrug analogs of 2’-deoxy-2’-fluoro-2’-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue activities in cellular assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8d10b314ef2182303dfcf7c75456ce
Publikováno v:
European Journal of Pharmaceutical Sciences. 92:110-116
Lipophilicity is one of the molecular properties assessed in early drug discovery. Direct measurement of the octanol-water distribution coefficient (logD) requires an analytical method with a large dynamic range or multistep dilutions, as the analyte
Autor:
Julien Lescar, Feng Gu, Kah Fei Wan, Francesca Blasco, CongBao Kang, Wai Ling Chan, Wei Liu, Paul W. Smith, Agatha Susila, Bin Zou, Qing Yin Wang, K.L. Yeo, Mei Ding, Chao Shan, Andy M. Yip, Haoying Xu, Hongping Dong, Jing Zou, Suresh B. Lakshminarayana, Ratna Karuna, Pei Yong Shi, Peck Gee Seah
Publikováno v:
Journal of Virology. 89:8233-8244
The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone compound that
Autor:
Hao Ying Xu, Wei Liu, Feng Gu, Bin Zou, Wai Ling Chan, Paul W. Smith, Kah Fei Wan, Ratna Karuna, Agatha Susila, Peck Gee Seah, Andy Yip, Pei Yong Shi, Trixie Wagner, Thierry T. Diagana, Qing Yin Wang, Alex Chao, Mei Ding, Hongping Dong, Seh Yong Leong, Francesca Blasco, Katherine Chan, Shahul Nilar, Ina Dix
Publikováno v:
ACS Medicinal Chemistry Letters. 6:344-348
Spiropyrazolopyridone 1 was identified, as a novel dengue virus (DENV) inhibitor, from a DENV serotype 2 (DENV-2) high-throughput phenotypic screen. As a general trend within this chemical class, chiral resolution of the racemate revealed that R enan