Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Francesca Avesani"'
Autor:
Maria Grazia Romanelli, Carlo Bidoia, Gianfranco Di Gennaro, Francesca Avesani, Marco Turci, Umberto Bertazzoni
Publikováno v:
Viruses, Vol 3, Iss 5, Pp 541-560 (2011)
Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible f
Externí odkaz:
https://doaj.org/article/1800d86e86c14ee6a6ea1d6d6f2121ce
Autor:
Maria Grazia Romanelli, Umberto Bertazzoni, Erica Diani, Elisa Bergamo, Giorgia Cremonese, Francesca Avesani
Publikováno v:
Virology. 476:92-99
The Tax protein expressed by human T-cell leukemia virus type 1 (HTLV-1) plays a pivotal role in the deregulation of cellular pathways involved in the immune response, inflammation, cell survival, and cancer. Many of these effects derive from Tax mul
Autor:
Umberto Bertazzoni, Maria Romanelli, Francesca Avesani, Gianfranco Di Gennaro, Marco Turci, Carlo Bidoia
Publikováno v:
Viruses
Viruses, Vol 3, Iss 5, Pp 541-560 (2011)
Viruses, Vol 3, Iss 5, Pp 541-560 (2011)
Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible f
Autor:
Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni, Carla Sampaio, Francesca Avesani, Gianfranco Di Gennaro, Marco Turci, Carlo Bidoia
Publikováno v:
Virology. 408:39-48
HTLV-1 is more pathogenic than HTLV-2 despite having a similar genome and closely related transactivating oncoproteins. Both Tax-1 protein from HTLV-1 and Tax-2 from HTLV-2 activate the NF-κB pathway. The mechanisms involved in Tax-1 deregulation of
Publikováno v:
Gene. 405:79-87
Raver1 is a ribonucleoprotein, evolutionarily conserved in mammals, which acts as a polypyrimidine tract-binding protein (PTB/hnRNPI) co-repressor in regulating alternative splicing events. The mouse homologue has been identified as a dual compartmen
Autor:
Maria Grazia Romanelli, Erica Diani, Agnese Filippello, Francesca Avesani, Pamela Lorenzi, Carlo Morandi
Raver2 is a putative modulator of the activity of the polypyrimidine-tract binding protein (PTB), one of the most intensively studied splicing repressors. Little is known about Raver2 expression, and all current data is from mice where it shows tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665a04116c109f179add0653f5f01914
http://hdl.handle.net/11562/390267
http://hdl.handle.net/11562/390267
Autor:
Marco Turci, Carla Sampaio, Pierre P. Roger, Françoise Bex, Julie Lodewick, Francesca Avesani, Maria Grazia Romanelli, Umberto Bertazzoni
Publikováno v:
Retrovirology
The Tax oncoprotein of HTLV-1 initiates T-cell transformation by dysregulating cell cycle progression and inhibiting DNA damage responses. The subsequent genomic instability might result in constitutive activation of the NF-κB pathway observed in HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c8636d1e5a85e9e40cbb17b307d9a9
http://hdl.handle.net/11562/390293
http://hdl.handle.net/11562/390293
Autor:
Gianfranco Di Gennaro, Erica Diani, Umberto Bertazzoni, Francesca Avesani, Giorgia Cremonese, Maria Romanelli, Marco Turci
Publikováno v:
Retrovirology
Retrovirology, Vol 8, Iss Suppl 1, p A137 (2011)
Retrovirology, Vol 8, Iss Suppl 1, p A137 (2011)
HTLV-1 Tax de-regulates several cellular signaling pathways leading to cell transformation by altering gene expression, intracellular protein distribution and cell proliferation. Tax-1 induces persistent activation of several transcriptional factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cede52b6a1fb3b6c35bfc40d92e7027
http://hdl.handle.net/11562/390453
http://hdl.handle.net/11562/390453
Autor:
Umberto Bertazzoni, Francesca Avesani, Maria Grazia Romanelli, Marco Turci, Oriano Marin, Gianfranco Di Gennaro, Giorgia Cremonese, Alessia Cotena, Erica Diani
Publikováno v:
Retrovirology
Post-translational modifications of HTLV-1 and HTLV-2 Tax-1 and Tax-2 proteins have been shown to play a critical role in their cellular localization, transactivation and protein interactions. Five of ten lysine residues were found to be major target