Výsledky vyhledávání - "Francesca A. Nimiyongskul"

Tertiary Mutations Stabilize CD8 + T Lymphocyte Escape-Associated Compensatory Mutations following Transmission of Simian Immunodeficiency Virus

Autor: Benjamin N. Bimber, Katherine B. Hammond, Tetsuro Matano, Enrique J. León, Masaru Yokoyama, Thomas C. Friedrich, Laura Newman, Jason S. Reed, Nicholas J. Maness, Hironori Sato, Jonah B. Sacha, Francesca A. Nimiyongskul, David H. O’Connor, Benjamin J. Burwitz, Helen L. Wu

Publikováno v: Journal of Virology. 88:3598-3604

Compensatory mutations offset fitness defects resulting from CD8 + T lymphocyte (CD8 TL )-mediated escape, but their impact on viral evolution following transmission to naive hosts remains unclear. Here, we investigated the reversion kinetics of Gag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251e2ddc804a0bee0f8d6c5c404e2ea1
https://doi.org/10.1128/jvi.03304-13

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Identification and spontaneous immune targeting of an endogenous retrovirus K envelope protein in the Indian rhesus macaque model of human disease

Autor: R. Brad Jones, Lyle T. Wallace, Philip A. Castrovinci, Robert J. Gifford, R. Paul Johnson, Laura Newman, Matthew B. Buechler, Enrique J. León, Jonah B. Sacha, Francesca A. Nimiyongskul, Helen L. Wu

Publikováno v: Retrovirology

Background Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections that have invaded the germ line of both humans and non-human primates. Most ERVs are functionally crippled by deletions, mutations, and hypermethylation, leading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129d2d7d67f04bdbbeb8d15ca35a2cb8
https://pubmed.ncbi.nlm.nih.gov/26767784

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