353 Amlitelimab reduces serum IL-13 in a phase 2a clinical trial in atopic dermatitis without impacting T-cell expansion in a T-cell recall assay

Autor: Stephan Weidinger, Michael Cork, Adam Reich, Thomas Bieber, Davide Lucchesi, Natalie Rynkiewicz, Richard C A Sainson, Ron Chen, Francesca Prandi, Cassandra van Krinks, Marisa Stebegg, Ben Porter-Brown

Publikováno v: British Journal of Dermatology. 188

Amlitelimab (SAR445229), a fully human non-depleting, non-cytotoxic, monoclonal antibody, binds to OX40Ligand (OX40L) on antigen-presenting cells (APC) to block OX40-OX40L interactions. In a 16-week, double-blind, Phase 2a trial (NCT03754309), amlite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4da0873c512e5d5e1544255e5d2889ac
https://doi.org/10.1093/bjd/ljac140.045

Mechanical compliance and immunological compatibility of fixative-free decellularized/cryopreserved human pericardium.

Autor: Maria Cristina Vinci, Giulio Tessitore, Laura Castiglioni, Francesca Prandi, Monica Soncini, Rosaria Santoro, Filippo Consolo, Francesca Colazzo, Barbara Micheli, Luigi Sironi, Gianluca Polvani, Maurizio Pesce

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64769 (2013)

BackgroundThe pericardial tissue is commonly used to produce bio-prosthetic cardiac valves and patches in cardiac surgery. The procedures adopted to prepare this tissue consist in treatment with aldehydes, which do not prevent post-graft tissue calci

Externí odkaz: https://doaj.org/article/357eabc4e45a449eb5f8b1a7116e660f

Epigenetic Profile of Human Adventitial Progenitor Cells Correlates With Therapeutic Outcomes in a Mouse Model of Limb Ischemia

Autor: Giuseppe Mangialardi, Vierlinger Klemens, Elisa Avolio, Paolo Madeddu, Jonathan Rowlinson, Maurizio Pesce, Gianni D Angelini, Miriam Gubernator, Simon Tavaré, Helen L Spencer, Federica Riu, Andrea Sottoriva, Sadie C. Slater, Manuela Hofner, Anestis Touloumis, Rajesh Katare, Carlotta Reni, Francesca Prandi, Costanza Emanueli, Paola Campagnolo, Inmaculada Spiteri, Gaia Spinetti, Atsuhiko Oikawa

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 35:675-688

Objective— We investigated the association between the functional, epigenetic, and expressional profile of human adventitial progenitor cells (APCs) and therapeutic activity in a model of limb ischemia. Approach and Results— Antigenic and functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1910c9bfc738cca7f9407f10860a7b22
https://doi.org/10.1161/atvbaha.114.304989

Human Saphenous Vein Response to Trans-wall Oxygen Gradients in a Novel Ex Vivo Conditioning Platform

Autor: Monica Soncini, Gianluca Polvani, Gianfranco Beniamino Fiore, Maurizio Pesce, Francesca Prandi, Marco Piola, Marco Agrifoglio

Autologous saphenous veins are commonly used for the coronary artery bypass grafting even if they are liable to progressive patency reduction, known as 'vein graft disease'. Although several cellular and molecular causes for vein graft disease have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fb0e1bb074139ba206ca1618827465
http://hdl.handle.net/11311/972374

Adventitial vessel growth and progenitor cells activation in an ex vivo culture system mimicking human saphenous vein wall strain after coronary artery bypass grafting

Autor: Gianluca Polvani, Carlo Gaetano, Gianfranco Beniamino Fiore, Eleonora Penza, Maurizio Pesce, Marco Piola, Yuri D'Alessandra, Monica Soncini, Francesca Prandi, Marco Agrifoglio, Maria Cristina Vinci, Claudia Colussi

Publikováno v: PloS one 10 (2015). doi:10.1371/journal.pone.0117409
info:cnr-pdr/source/autori:Prandi, Francesca; Piola, Marco; Soncini, Monica; Colussi, Claudia; D'Alessandra, Yuri; Penza, Eleonora; Agrifoglio, Marco; Vinci, Maria Cristina; Polvani, Gianluca; Gaetano, Carlo; Fiore, Gianfranco Beniamino; Pesce, Maurizio/titolo:Adventitial Vessel Growth and Progenitor Cells Activation in an Ex Vivo Culture System Mimicking Human Saphenous Vein Wall Strain after Coronary Artery Bypass Grafting/doi:10.1371%2Fjournal.pone.0117409/rivista:PloS one/anno:2015/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
PLoS ONE, Vol 10, Iss 2, p e0117409 (2015)
PLoS ONE

Saphenous vein graft disease is a timely problem in coronary artery bypass grafting. Indeed, after exposure of the vein to arterial blood flow, a progressive modification in the wall begins, due to proliferation of smooth muscle cells in the intima.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458860edb6daba38d60a771c3a2afb27
http://hdl.handle.net/11311/965763