Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Francesca, Macchiarini"'
Autor:
Richard A. Miller, David E. Harrison, David B. Allison, Molly Bogue, Lucas Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej Galecki, W. Timothy Garvey, Hashan Jayarathne, Navasuja Kumar, Martin A. Javors, Warren C. Ladiges, Francesca Macchiarini, James Nelson, Peter Reifsnyder, Nadia A. Rosenthal, Marianna Sadagurski, Adam B. Salmon, Daniel L. Smith Jr., Jessica M. Snyder, David B. Lombard, Randy Strong
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
Canagliflozin (Cana) is an FDA-approved diabetes drug that protects against cardiovascular and kidney diseases. It also inhibits the sodium glucose transporter 2 by blocking renal reuptake and intestinal absorption of glucose. In the context of the m
Externí odkaz:
https://doaj.org/article/8346a43abd5742d2afbdcea95b0aa4d1
Autor:
Jessica M. Snyder, Kerriann M. Casey, Andrzej Galecki, David E. Harrison, Hashan Jayarathne, Navasuja Kumar, Francesca Macchiarini, Nadia Rosenthal, Marianna Sadagurski, Adam B. Salmon, Randy Strong, Richard A. Miller, Warren Ladiges
Publikováno v:
GeroScience. 45:385-397
Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in median lifespan and a 9% increase in the 90th percentile age when given to genetically heterogeneous male mice from 7 months of age, but does not increase lif
Autor:
David E. Harrison, Randy Strong, Peter Reifsnyder, Navasuja Kumar, Elizabeth Fernandez, Kevin Flurkey, Martin A. Javors, Marisa Lopez‐Cruzan, Francesca Macchiarini, James F. Nelson, Adrian Markewych, Alessandro Bitto, Amy L. Sindler, Gino Cortopassi, Kylie Kavanagh, Lin Leng, Richard Bucala, Nadia Rosenthal, Adam Salmon, Timothy M. Stearns, Molly Bogue, Richard A. Miller
Publikováno v:
Aging Cell
Aging cell, vol 20, iss 5
Aging cell, vol 20, iss 5
In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non‐feminizing” estrogen, 17‐α‐estradiol (17aE2), extended median male lifespan by 19% (p
Interventions that increase lifespan when started late in life ar
Interventions that increase lifespan when started late in life ar
Autor:
Michael P. Murphy, James F. Nelson, Elizabeth Fernandez, Arlan Richardson, David E. Harrison, Richard A. Miller, Peter Reifsnyder, Molly A. Bogue, Adam B. Salmon, Martin A. Javors, Nicolas Musi, Randy Strong, Michael Petrascheck, Paul Anthony Marinez, Francesca Macchiarini, Sergiy Libert
Publikováno v:
Aging Cell
To see if variations in timing of rapamycin (Rapa), administered to middle aged mice starting at 20 months, would lead to different survival outcomes, we compared three dosing regimens. Initiation of Rapa at 42 ppm increased survival significantly in
Autor:
Francesca Macchiarini, Molly A. Bogue, Jessica M. Snyder, Nadia Rosenthal, Peter Reifsnyder, Andrzej T. Galecki, James F. Nelson, Warren C Ladies, Richard A. Miller, David B. Allison, Martin A. Javors, Daniel L. Smith, Randy Strong, Elizabeth Fernandez, Vivian Diaz, Navasuja Kumar, David E. Harrison, W. Timothy Garvey, Adam B. Salmon, David B. Lombard
Canagliflozin (Cana) is an inhibitor of the sodium glucose transporter 2 (SGLT2), and is thought to act by blocking renal reuptake and intestinal absorption of glucose. Cana is FDA-approved for treatment of diabetes, and affords protection from cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d7c952dcb41918aa25bca60e14631f
https://doi.org/10.1101/2020.05.23.112763
https://doi.org/10.1101/2020.05.23.112763
Autor:
Mercy PrabhuDas, Danielle M. Carrick, Michelle R. J. Hamlet, Johanna T. Dwyer, Christina H. Liu, Pushpa Tandon, Merriline M. Vedamony, Natalie Abrams, Grace L. Shen, Francesca Macchiarini, Preethi Chander
Publikováno v:
Nature Immunology. 18:1175-1180
The US National Institutes of Health convened a workshop on disease-promoting chronic inflammation to identify the challenges and needs in the development of clinically feasible strategies for monitoring a person's inflammation status before, during
Autor:
Steven G. Deeks, Arti Hurria, Jeffrey B. Halter, Felipe Sierra, Robin Huebner, Claudia Gravekamp, Ronald A. Kohanski, Paige A. Green, Kevin P. High, Rebecca Fuldner, Francesca Macchiarini
Publikováno v:
Annals of the New York Academy of Sciences. 1386:30-44
Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity. Geroscience provides links among the biology of aging, the biology of disease, and the physiology of frailty, three fields where enormous pro
Autor:
Tim Stearns, Randy Strong, Elizabeth Fernandez, Richard A. Miller, Joel Brind, James F. Nelson, Alexey G. Ryazanov, Martin A. Javors, Warren Ladiges, Kevin Flurkey, Molly A. Bogue, Douglas E. Vaughan, Jessica M. Snyder, C. Michael Astle, David E. Harrison, Christiaan Leeuwenburgh, Francesca Macchiarini
Publikováno v:
Aging Cell
Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore e
Autor:
Lynne Wathen, Francesca Macchiarini, Carmen Rios, Chad Hrdina, Mary J. Homer, Bert W. Maidment, Andrea L. DiCarlo-Cohen, Robert E. Raulli, Brian R. Moyer, Pataje G. S. Prasanna, John L. Esker
Publikováno v:
Radiation Protection Dosimetry. 171:85-98
The United States Department of Health and Human Services (HHS) is fully committed to the development of medical countermeasures to address national security threats from chemical, biological, radiological, and nuclear agents. Through the Public Heal