Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Francesca, Khani"'
Autor:
Kentaro Ohara, André Figueiredo Rendeiro, Bhavneet Bhinder, Kenneth Wha Eng, Hiranmayi Ravichandran, Duy Nguyen, David Pisapia, Aram Vosoughi, Evan Fernandez, Kyrillus S. Shohdy, Jyothi Manohar, Shaham Beg, David Wilkes, Brian D. Robinson, Francesca Khani, Rohan Bareja, Scott T. Tagawa, Madhu M. Ouseph, Andrea Sboner, Olivier Elemento, Bishoy M. Faltas, Juan Miguel Mosquera
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The molecular characteristics of metastatic upper tract urothelial carcinoma (UTUC) are not well understood, and there is a lack of knowledge regarding the genomic and transcriptomic differences between primary and metastatic UTUC. To addres
Externí odkaz:
https://doaj.org/article/1f8f0d770af047ad8d9323c78d5a4be4
Autor:
Hubert Pakula, Mohamed Omar, Ryan Carelli, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Tania Pannellini, Fabio Socciarelli, Lucie Van Emmenis, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier Vitale Nuzzo, Nicholas J. Brady, Wikum Dinalankara, Madhavi Jere, Itzel Valencia, Christopher Saladino, Jason Stone, Caitlin Unkenholz, Richard Garner, Mohammad K. Alexanderani, Francesca Khani, Francisca Nunes de Almeida, Cory Abate-Shen, Matthew B. Greenblatt, David S. Rickman, Christopher E. Barbieri, Brian D. Robinson, Luigi Marchionni, Massimo Loda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular
Externí odkaz:
https://doaj.org/article/f358a6f85a6c4b2189686dbb0cfa358f
Autor:
Francesca Khani, William F. Hooper, Xiaofei Wang, Timothy R. Chu, Minita Shah, Lara Winterkorn, Michael Sigouros, Vincenza Conteduca, David Pisapia, Sara Wobker, Sydney Walker, Julie N. Graff, Brian Robinson, Juan Miguel Mosquera, Andrea Sboner, Olivier Elemento, Nicolas Robine, Himisha Beltran
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)
Abstract Intracranial metastases in prostate cancer are uncommon but clinically aggressive. A detailed molecular characterization of prostate cancer intracranial metastases would improve our understanding of their pathogenesis and the search for new
Externí odkaz:
https://doaj.org/article/2c7abc5566ae469cb19e563f5d304fac
Autor:
Johannes C. van der Mijn, Kristian B. Laursen, Leiping Fu, Francesca Khani, Lukas E. Dow, Dawid G. Nowak, Qiuying Chen, Steven S. Gross, David M. Nanus, Lorraine J. Gudas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Genetically engineered mouse models (GEMMs) are important immunocompetent models for research into the roles of individual genes in cancer and the development of novel therapies. Here we use inducible CRISPR-Cas9 systems to develop two GEMMs
Externí odkaz:
https://doaj.org/article/663f362a226d470abe3578034e1b34b8
166 Radiation Therapy and IRreversible Electroporation (RTIRE) for Intermediate Risk Prostate Cancer
Autor:
Timothy McClure, Francesca Khani, Brian Robinson, Ariel E Marciscano, Christopher Barbieri, Joseph Osborne, Himanshu Nagar
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 50-50 (2024)
OBJECTIVES/GOALS: Prostate cancer treatment is associated with significant genitourinary side effects. There is a critical need for treatment with decreased morbidity. We report the development of a novel treatment paradigm combining irreversible ele
Externí odkaz:
https://doaj.org/article/e01b66cb89174ffb9c9200bac008acf9
Author Correction: Evolution of structural rearrangements in prostate cancer intracranial metastases
Autor:
Francesca Khani, William F. Hooper, Xiaofei Wang, Timothy R. Chu, Minita Shah, Lara Winterkorn, Michael Sigouros, Vincenza Conteduca, David Pisapia, Sara Wobker, Sydney Walker, Julie N. Graff, Brian Robinson, Juan Miguel Mosquera, Andrea Sboner, Olivier Elemento, Nicolas Robine, Himisha Beltran
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/5cbc5bff8e0144b2828d406b46650b79
Autor:
Veronika M. Metzler, Simone de Brot, Daisy B. Haigh, Corinne L. Woodcock, Jennifer Lothion-Roy, Anna E. Harris, Emeli M. Nilsson, Atara Ntekim, Jenny L. Persson, Brian D. Robinson, Francesca Khani, Kristian B. Laursen, Lorraine J. Gudas, Michael S. Toss, Srinivasan Madhusudan, Emad Rakha, David M. Heery, Catrin S. Rutland, Nigel P. Mongan, Jennie N. Jeyapalan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types
Externí odkaz:
https://doaj.org/article/a03a643cd6764996be2ac0f2c2df949e
Autor:
Jennifer Lothion-Roy, Daisy B. Haigh, Anna E. Harris, Veronika M. Metzler, Mansour Alsaleem, Michael S. Toss, Yousif Kariri, Atara Ntekim, Brian D. Robinson, Francesca Khani, Lorraine J. Gudas, Cinzia Allegrucci, Victoria H. James, Srinivasan Madhusudan, Melissa Mather, Richard D. Emes, Nathan Archer, Rupert G. Fray, Emad Rakha, Jennie N. Jeyapalan, Catrin S. Rutland, Nigel P. Mongan, Corinne L. Woodcock
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are
Externí odkaz:
https://doaj.org/article/ee16cd5a10274e0e9f3c44999cecb5f8
Autor:
Paloma Cejas, Yingtian Xie, Alba Font-Tello, Klothilda Lim, Sudeepa Syamala, Xintao Qiu, Alok K. Tewari, Neel Shah, Holly M. Nguyen, Radhika A. Patel, Lisha Brown, Ilsa Coleman, Wenzel M. Hackeng, Lodewijk Brosens, Koen M. A. Dreijerink, Leigh Ellis, Sarah Abou Alaiwi, Ji-Heui Seo, Sylvan Baca, Himisha Beltran, Francesca Khani, Mark Pomerantz, Alessandra Dall’Agnese, Jett Crowdis, Eliezer M. Van Allen, Joaquim Bellmunt, Colm Morrisey, Peter S. Nelson, James DeCaprio, Anna Farago, Nicholas Dyson, Benjamin Drapkin, X. Shirley Liu, Matthew Freedman, Michael C. Haffner, Eva Corey, Myles Brown, Henry W. Long
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while dist
Externí odkaz:
https://doaj.org/article/049dc4c6a6fd4e8a9fc4ad8f4f885b4e
Autor:
Anna E. Harris, Veronika M. Metzler, Jennifer Lothion-Roy, Dhruvika Varun, Corinne L. Woodcock, Daisy B. Haigh, Chantelle Endeley, Maria Haque, Michael S. Toss, Mansour Alsaleem, Jenny L. Persson, Lorraine J. Gudas, Emad Rakha, Brian D. Robinson, Francesca Khani, Laura M. Martin, Jenna E. Moyer, Juliette Brownlie, Srinivasan Madhusudan, Cinzia Allegrucci, Victoria H. James, Catrin S. Rutland, Rupert G. Fray, Atara Ntekim, Simone de Brot, Nigel P. Mongan, Jennie N. Jeyapalan
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic
Externí odkaz:
https://doaj.org/article/cdc6c0e64c544575b4a2feb180c39250