Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Francesca, Buffa"'
Autor:
Ka-Liong Tan, Syed Haider, Christos E. Zois, Jianting Hu, Helen Turley, Russell Leek, Francesca Buffa, Oreste Acuto, Adrian L. Harris, Francesco Pezzella
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102106- (2024)
Current prognostic biomarkers fall short in stratifying Oestrogen receptor (ER)-negative breast cancer patients regarding tumour progression risk at diagnosis. The role of AIPL1 in activating its tumour suppressor client protein, NEDD8 Ultimate Buste
Externí odkaz:
https://doaj.org/article/9929b2fc3b5b4dfba1631ace026e5e2e
Autor:
Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie Samuel, Graeme Murray, David Sebag-Montefiore, Simon Gollins, Nicholas West, Rubina Begum, Susan Richman, Phil Quirke, Keara Redmond, Aikaterini Chatzipli, Alessandro Barberis, Sylvana Hassanieh, Umair Mahmood, Michael Youdell, Ultan McDermott, Viktor Koelzer, Simon Leedham, Ian Tomlinson, Philip Dunne, Francesca M. Buffa, Timothy S. Maughan, Francesca Buffa, Geoffrey Higgins, Christopher Holmes, Timothy Maughan, Gillies McKenna, James Robineau, Philip Quirke, Matthew Seymour, Richard Kennedy, Mark Lawler, Manuel Salto-Tellez, Peter Campbell, Claire Hardy, Simon Bach, Andrew Beggs, Jean-Baptiste Cazier, Gary Middleton, Dion Morton, Celina Whalley, Louise Brown, Richard Kaplan, Richard Wilson, Richard Adams, Richard Sullivan, Paul Harkin, Steven Walker, Jim Hill, Chieh-Hsi Wu, Dennis Horgan
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105228- (2024)
Summary: Background: It is uncertain which biological features underpin the response of rectal cancer (RC) to radiotherapy. No biomarker is currently in clinical use to select patients for treatment modifications. Methods: We identified two cohorts o
Externí odkaz:
https://doaj.org/article/6732596b11c54a618ebd9beb8dd8725c
Autor:
Srinivasa Rao, Clare Verrill, Lucia Cerundolo, Nasullah Khalid Alham, Zeynep Kaya, Miriam O’Hanlon, Alicia Hayes, Adam Lambert, Martha James, Iain D. C. Tullis, Jane Niederer, Shelagh Lovell, Altan Omer, Francisco Lopez, Tom Leslie, Francesca Buffa, Richard J. Bryant, Alastair D. Lamb, Boris Vojnovic, David C. Wedge, Ian G. Mills, Dan J. Woodcock, Ian Tomlinson, Freddie C. Hamdy
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant research on tumour evolution in prostate cancer metastasis, the emergence and evolut
Externí odkaz:
https://doaj.org/article/fea0ecc091594c4e9bf661d9a47540cf
Autor:
Hira Javaid, Alessandro Barberis, Olga Chervova, Isar Nassiri, Vitaly Voloshin, Yusuke Sato, Seishi Ogawa, Benjamin Fairfax, Francesca Buffa, Timothy C. Humphrey
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss and depletion on DNA methylatio
Externí odkaz:
https://doaj.org/article/f45505e3c69845fc98f7c5247001d2e6
Autor:
Helen Sheldon, Wei Zhang, Esther Bridges, Koon Hwee Ang, Salwa Lin, Massimo Masiero, Demin Li, Penny A. Handford, Pat Whiteman, Roman Fischer, Francesca Buffa, Manu Vatish, Alison H. Banham, Adrian L. Harris
Publikováno v:
Journal of Extracellular Biology, Vol 1, Iss 8, Pp n/a-n/a (2022)
Abstract ELTD1/ADGRL4 is an adhesion GPCR with an important role in angiogenesis. We recently identified a role for ELTD1 in wound repair and inflammation. Activation of ELTD1 in endothelial cells results in a type II EMT to myofibroblast‐like cell
Externí odkaz:
https://doaj.org/article/96159b7c9b4047979156dffb776d91ce
Autor:
Claire A Walsh, Nina Akrap, Elena Garre, Ylva Magnusson, Hannah Harrison, Daniel Andersson, Emma Jonasson, Svanheidur Rafnsdottir, Hani Choudhry, Francesca Buffa, Jiannis Ragoussis, Anders Ståhlberg, Adrian Harris, Göran Landberg
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236187 (2020)
The definitive characterization of common cancer stem cell (CSCs) subpopulations in breast cancer subtypes with distinct genotypic and phenotypic features remains an ongoing challenge. In this study, we have used a non-biased genome wide screening ap
Externí odkaz:
https://doaj.org/article/e1715fcef590406caf5e91eba60549d3
Autor:
Angelos Papaspyropoulos, Leanne Bradley, Asmita Thapa, Chuen Yan Leung, Konstantinos Toskas, Delia Koennig, Dafni-Eleftheria Pefani, Cinzia Raso, Claudia Grou, Garth Hamilton, Nikola Vlahov, Anna Grawenda, Syed Haider, Jagat Chauhan, Ludovico Buti, Alexander Kanapin, Xin Lu, Francesca Buffa, Grigory Dianov, Alex von Kriegsheim, David Matallanas, Anastasia Samsonova, Magdalena Zernicka-Goetz, Eric O’Neill
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
In development, the switch from pluripotency to differentiation is important but it is often unclear how it is regulated. Here, the authors show that the tumour suppressor RASSF1A mediates this switch by promoting YAP-p73 transcription, which in turn
Externí odkaz:
https://doaj.org/article/851da86c94cb4859a74e3f6c31088f3a
Autor:
Chen-Chun Pai, Samuel C Durley, Wei-Chen Cheng, Nien-Yi Chiang, Jennifer Peters, Torben Kasparek, Elizabeth Blaikley, Boon-Yu Wee, Carol Walker, Stephen E Kearsey, Francesca Buffa, Johanne M Murray, Timothy C Humphrey
Chromosomal instability (CIN) drives cell-to-cell heterogeneity, and the development of genetic diseases, including cancer. Impaired homologous recombination (HR) has been implicated as a major driver of CIN, however, the underlying mechanism remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430e423c224ed90a7ebfeba2d915668a
https://doi.org/10.1093/nar/gkad160
https://doi.org/10.1093/nar/gkad160
Autor:
John M. Findlay, Francesc Castro-Giner, Seiko Makino, Emily Rayner, Christiana Kartsonaki, William Cross, Michal Kovac, Danny Ulahannan, Claire Palles, Richard S. Gillies, Thomas P. MacGregor, David Church, Nicholas D. Maynard, Francesca Buffa, Jean-Baptiste Cazier, Trevor A. Graham, Lai-Mun Wang, Ricky A. Sharma, Mark Middleton, Ian Tomlinson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Oesophageal adenocarcinoma is often treated with chemotherapy before surgery. Here, the authors sequence cancer samples before and after chemotherapy and examine how the genome changes, focusing on changes in driver gene mutations and differential cl
Externí odkaz:
https://doaj.org/article/1aea2f25e1f04ce696257305762bffaf
Autor:
Srinivasa Rao, Clare Verrill, Lucia Cerundolo, Nasullah Khalid Alham, Zeynep Kaya, Miriam O’Hanlon, Alicia Hayes, Adam Lambert, Martha James, Iain D. C. Tullis, Jane Niederer, Shelagh Lovell, Altan Omer, Francisco Lopez, Tom Leslie, Francesca Buffa, Richard J. Bryant, Alastair D. Lamb, Boris Vojnovic, David C. Wedge, Ian G. Mills, Dan J. Woodcock, Ian Tomlinson, Freddie C. Hamdy
Extension of prostate cancer beyond the primary site into the surrounding organs by local invasion or nodal metastasis is associated with poor prognosis. The emergence and evolution of cancer clones at this early stage of expansion and spread has not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5536552f419f740c8133217262863860
https://doi.org/10.1101/2023.02.27.530113
https://doi.org/10.1101/2023.02.27.530113