Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

Autor: Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increas

Externí odkaz: https://doaj.org/article/fd9905e2c6a74145a36f74cbae797fa7

PAR1 Expression Predicts Clinical G-CSF CD34+ HSPC Mobilization and Repopulation Potential in Transplanted Patients

Autor: Neta Nevo, Tsila Zuckerman, Shiri Gur-Cohen, Orit Kollet, Francesca Avemaria, Elizabeth J. Shpall, Mayela C. Mendt, Arnon Nagler, Benjamin Brenner, Myriam Ben Arush, Tsvee Lapidot

Publikováno v: HemaSphere, Vol 3, Iss 5 (2019)

Externí odkaz: https://doaj.org/article/dcb5ff6428b844599f31440203785f77

VLA-4 Affinity Assay for Murine Bone Marrow-derived Hematopoietic Stem Cells

Autor: Francesca Avemaria, Shiri Gur-Cohen, Seymen Avci, Tsvee Lapidot

Publikováno v: Bio-Protocol, Vol 7, Iss 4 (2017)

Hematopoietic stem cells (HSCs) are defined by their functional ability to self-renew and to differentiate into all blood cell lineages. The majority of HSC reside in specific anatomical locations in the bone marrow (BM) microenvironment, in a quiesc

Externí odkaz: https://doaj.org/article/130b56b2af3b4049b7f58488b7cc5f41

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

Autor: Asaf Spiegel, Hassan Massalha, Shalev Itzkovitz, Orit Kollet, Eman Khatib-Massalha, Isabell Brandenburger, Suditi Bhattacharya, Francesca Avemaria, Ronen Alon, Ziv Shulman, Zachary Gerhart-Hines, Amiram Ariel, Tsvee Lapidot, Tomer Itkin, Adi Biram, Karin Golan, Ekaterina Petrovich-Kopitman, Anju Kumari, Stefan Offermanns, Matthias Gunzer, Shiri Gur-Cohen

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Khatib-Massalha, E, Bhattacharya, S, Massalha, H, Biram, A, Golan, K, Kollet, O, Kumari, A, Avemaria, F, Petrovich-Kopitman, E, Gur-Cohen, S, Itkin, T, Brandenburger, I, Spiegel, A, Shulman, Z, Gerhart-Hines, Z, Itzkovitz, S, Gunzer, M, Offermanns, S, Alon, R, Ariel, A & Lapidot, T 2020, ' Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling ', Nature Communications, vol. 11, no. 1, 3547 . https://doi.org/10.1038/s41467-020-17402-2

Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and their contribution to neut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667e4c7ed3f2c2e96b61e3d338fc5f95
http://link.springer.com/article/10.1038/s41467-020-17402-2

PDCD10 gene mutations in multiple cerebral cavernous malformations.

Autor: Maria Sole Cigoli, Francesca Avemaria, Stefano De Benedetti, Giovanni P Gesu, Lucio Giordano Accorsi, Stefano Parmigiani, Maria Franca Corona, Valeria Capra, Andrea Mosca, Simona Giovannini, Francesca Notturno, Fausta Ciccocioppo, Lilia Volpi, Margherita Estienne, Giuseppe De Michele, Antonella Antenora, Leda Bilo, Antonietta Tavoni, Nelia Zamponi, Enrico Alfei, Giovanni Baranello, Daria Riva, Silvana Penco

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110438 (2014)

Cerebral cavernous malformations (CCMs) are vascular abnormalities that may cause seizures, intracerebral haemorrhages, and focal neurological deficits. Familial form shows an autosomal dominant pattern of inheritance with incomplete penetrance and v

Externí odkaz: https://doaj.org/article/a3dbd19d4c54492f97dfb9a8f5158c0a