Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Francesca, Ambri"'
1
Akademický článek
Integrating continuous hypermutation with high‐throughput screening for optimization of cis,cis‐muconic acid production in yeast
Autor: Emil D. Jensen, Francesca Ambri, Marie B. Bendtsen, Alex A. Javanpour, Chang C. Liu, Michael K. Jensen, Jay D. Keasling
Publikováno v: Microbial Biotechnology, Vol 14, Iss 6, Pp 2617-2626 (2021)
Summary Directed evolution is a powerful method to optimize proteins and metabolic reactions towards user‐defined goals. It usually involves subjecting genes or pathways to iterative rounds of mutagenesis, selection and amplification. While powerfu
Externí odkaz: https://doaj.org/article/2dcfe0c268f74d13888f38a9b161fae9
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2
Akademický článek
Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models
Autor: Morteza Chalabi Hajkarim, Ella Karjalainen, Mikhail Osipovitch, Konstantinos Dimopoulos, Sandra L Gordon, Francesca Ambri, Kasper Dindler Rasmussen, Kirsten Grønbæk, Kristian Helin, Krister Wennerberg, Kyoung-Jae Won
Publikováno v: eLife, Vol 11 (2022)
Large-scale multiparameter screening has become increasingly feasible and straightforward to perform thanks to developments in technologies such as high-content microscopy and high-throughput flow cytometry. The automated toolkits for analyzing simil
Externí odkaz: https://doaj.org/article/3f675683279247e3902e4a69cb12b59a
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3
H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway
Autor: Anne Meldgaard Hansen, Ying Ge, Mikkel Bruhn Schuster, Sachin Pundhir, Janus Schou Jakobsen, Adrija Kalvisa, Marta Cecylia Tapia, Sandra Gordon, Francesca Ambri, Frederik Otzen Bagger, Deo Pandey, Kristian Helin, Bo Torben Porse
Publikováno v: Science Advances. 8
Activation of interferon genes constitutes an important anticancer pathway able to restrict proliferation of cancer cells. Here, we demonstrate that the H3K9me3 histone methyltransferase (HMT) suppressor of variegation 3–9 homolog 1 (SUV39H1) is re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923df6bd828dac7cf3621df59daa10e6
https://doi.org/10.1126/sciadv.abf8627
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5
Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models
Autor: Ella Karjalainen, Morteza Chalabi Hajkarim, Mikhail Osipovitch, Konstantinos Dimopoulos, Sandra L Gordon, Francesca Ambri, Kasper Dindler Rasmussen, Kirsten Grønbæk, Kristian Helin, Krister Wennerberg, Kyoung-Jae Won
Publikováno v: Chalabi Hajkarim, M, Karjalainen, E, Osipovitch, M, Dimopoulos, K, Gordon, S L, Ambri, F, Rasmussen, K D, Grønbæk, K, Helin, K, Wennerberg, K & Won, K-J 2022, ' Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models ', eLife, vol. 11, e73760 . https://doi.org/10.7554/eLife.73760
Large-scale multiparameter screening has become increasingly feasible and straightforward to perform thanks to developments in technologies such as high-content microscopy and high-throughput flow cytometry. The automated toolkits for analyzing simil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7a199d9f50566a99a89ca2b875725a
https://curis.ku.dk/portal/da/publications/comprehensive-and-unbiased-multiparameter-highthroughput-screening-by-compare-finds-effective-and-subtle-drug-responses-in-aml-models(e0f96da2-3ced-4480-acad-eabd0e85cb66).html
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7
Integrating continuous hypermutation with high-throughput screening for optimization of cis,cis-muconic acid production in yeast
Autor: Marie Blatt Bendtsen, Francesca Ambri, Alex A. Javanpour, Jay D. Keasling, Chang C. Liu, Michael Krogh Jensen, Emil D. Jensen
Publikováno v: Jensen, E D, Ambri, F, Bendtsen, M B, Javanpour, A A, Liu, C C, Jensen, M K & Keasling, J D 2021, ' Integrating continuous hypermutation with high-throughput screening for optimization of cis,cis-muconic acid production in yeast ', Microbial Biotechnology, vol. 14, no. 6, pp. 2617-2626 . https://doi.org/10.1111/1751-7915.13774
Microbial Biotechnology
Microbial Biotechnology, Vol 14, Iss 6, Pp 2617-2626 (2021)
Summary Directed evolution is a powerful method to optimize proteins and metabolic reactions towards user‐defined goals. It usually involves subjecting genes or pathways to iterative rounds of mutagenesis, selection and amplification. While powerfu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7e1e2e8bf3456bf82ca945dd13e1a0
https://doi.org/10.1101/2020.12.09.418236
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8
Regulatory control circuits for stabilizing long-term anabolic product formation in yeast
Autor: Michael Krogh Jensen, Morten Otto Alexander Sommer, Jay D. Keasling, Robert Mans, Jolanda ter Horst, Francesca Ambri, Roberto Di Blasi, Vasil D'ambrosio, Marcel van den Broek, Eleonora Dore, Peter Rugbjerg, Suresh Sudarsan
Publikováno v: Metabolic Engineering, 61
D'ambrosio, V, Dore, E, Di Blasi, R, van den Broek, M, Sudarsan, S, ter Horst, J, Ambri, F, Sommer, M O A, Rugbjerg, P, Keasling, J D, Mans, R & Jensen, M K 2020, ' Regulatory control circuits for stabilizing long-term anabolic product formation in yeast ', Metabolic Engineering, vol. 61, pp. 369-380 . https://doi.org/10.1016/j.ymben.2020.07.006
Metabolic Engineering
Engineering living cells for production of chemicals, enzymes and therapeutics can burden cells due to use of limited native co-factor availability and/or expression burdens, totalling a fitness deficit compared to parental cells encoded through long
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97db74f5f9544ff063354d4e32b0d86
https://escholarship.org/uc/item/0cg460bm
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9
High-Resolution Scanning of Optimal Biosensor Reporter Promoters in Yeast
Autor: Simo Abdessamad Baallal Jacobsen, Douglas McCloskey, Francesca Ambri, Vasil D'ambrosio, Jay D. Keasling, Jerome Maury, Roberto Di Blasi, Michael Krogh Jensen
Publikováno v: ACS synthetic biology, vol 9, iss 2
Ambri, F, D'ambrosio, V, Di Blasi, R, Maury, J, Baallal Jacobsen, S A, McCloskey, D, Jensen, M K & Keasling, J D 2020, ' High-resolution scanning of optimal biosensor reporter promoters in yeast ', ACS Synthetic Biology, vol. 9, no. 2, pp. 218-226 . https://doi.org/10.1021/acssynbio.9b00333
Small-molecule binding allosteric transcription factors (aTFs) derived from bacteria enable real-time monitoring of metabolite abundances, high-throughput screening of genetic designs, and dynamic control of metabolism. Yet, engineering of reporter p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e1662d3644cd0611db40acc6658abd
https://escholarship.org/uc/item/4d10205b
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10
Evolution-guided engineering of small-molecule biosensors
Autor: Stefan Kol, Tim Snoek, Jay D. Keasling, Evan K. Chaberski, Michael Krogh Jensen, Francesca Ambri, Bo Pang, Ditte Hededam Welner, Sara Petersen Bjørn, Jesus F. Barajas
Publikováno v: Snoek, T, Chaberski, E K, Ambri, F, Kol, S, Bjørn, S P, Pang, B, Barajas, J F, Welner, D H, Jensen, M K & Keasling, J D 2020, ' Evolution-guided engineering of small-molecule biosensors ', Nucleic Acids Research, vol. 48, no. 1, e3 . https://doi.org/10.1093/nar/gkz954
Nucleic Acids Research
Nucleic acids research, vol 48, iss 1
Allosteric transcription factors (aTFs) have proven widely applicable for biotechnology and synthetic biology as ligand-specific biosensors enabling real-time monitoring, selection and regulation of cellular metabolism. However, both the biosensor sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5846de13a82e0c9747ca57f322b740ee
https://orbit.dtu.dk/en/publications/fe61f6b4-a0f1-4a37-8709-4627dcbd5d83
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