Profiling bitter taste receptors (TAS2R) along the gastrointestinal tract and their influence on enterohormone secretion. Gender- and age-related effects in the colon

Autor: Florijan Jalševac, Maria Descamps-Solà, Carme Grau-Bové, Helena Segú, Teresa Auguet, Francesc Xavier Avilés-Jurado, Francesc Balaguer, Rosa Jorba, Raúl Beltrán-Debón, Maria Teresa Blay, Ximena Terra Barbadora, Montserrat Pinent, Anna Ardévol

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

Extraoral bitter taste receptors offer intriguing potential for modulating metabolism and the gut-brain axis through dietary interventions. Our understanding of these receptors is limited, and data on their effects on ageing are scarce. The complexit

Externí odkaz: https://doaj.org/article/605a5cf60f7a4f81940137b6577af331

Isolation and Characterization of NpCI, a New Metallocarboxypeptidase Inhibitor from the Marine Snail Nerita peloronta with Anti-Plasmodium falciparum Activity

Autor: Aymara Cabrera-Muñoz, Yusvel Sierra-Gómez, Giovanni Covaleda-Cortés, Mey L. Reytor, Yamile González-González, José M. Bautista, Francesc Xavier Avilés, Maday Alonso-del-Rivero

Publikováno v: Marine Drugs, Vol 21, Iss 2, p 94 (2023)

Metallocarboxypeptidases are zinc-dependent peptide-hydrolysing enzymes involved in several important physiological and pathological processes. They have been a target of growing interest in the search for natural or synthetic compound binders with b

Externí odkaz: https://doaj.org/article/1711ed6bc716491d8c9ed618244e4455

Enhanced Production of ECM Proteins for Pharmaceutical Applications Using Mammalian Cells and Sodium Heparin Supplementation

Autor: Javier Garcia-Pardo, Sergi Montané, Francesc Xavier Avilés, Sebastian Tanco, Julia Lorenzo

Publikováno v: Pharmaceutics, Vol 14, Iss 10, p 2138 (2022)

The yields of soluble ECM proteins recombinantly produced with mammalian cells can be significantly enhanced by exploiting the stabilizing properties of heparin. Here, we propose a simple and straightforward scalable protocol for the mammalian cell p

Externí odkaz: https://doaj.org/article/877e0d250a7146a5b7a404ccca3a261b

Substrate Specificity and Structural Modeling of Human Carboxypeptidase Z: A Unique Protease with a Frizzled-Like Domain

Autor: Javier Garcia-Pardo, Sebastian Tanco, Maria C. Garcia-Guerrero, Sayani Dasgupta, Francesc Xavier Avilés, Julia Lorenzo, Lloyd D. Fricker

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 22, p 8687 (2020)

Metallocarboxypeptidase Z (CPZ) is a secreted enzyme that is distinguished from all other members of the M14 metallocarboxypeptidase family by the presence of an N-terminal cysteine-rich Frizzled-like (Fz) domain that binds Wnt proteins. Here, we pre

Externí odkaz: https://doaj.org/article/c221af52bb1f4c62aa74e8a17b9b3f6c

Timing of elective tracheotomy and duration of mechanical ventilation among patients admitted to intensive care with severe COVID ‐19: A multicenter prospective cohort study

Autor: Gabriela Simonetti, Vanessa Villarraga, Albert Prats-Uribe, Estefania Hernandez-Garcia, Clara Garcia-Bastida, Nieves Mata-Castro, Carlos M. Chiesa-Estomba, Pablo Parente-Arias, Victoria Duque Holguera, Alvaro Sanchez Barrueco, Laura Rodriganez, Jordi Rello, Isabel Vilaseca, Daniel Poletti, Jose Miguel Villacampa, Adriana Agüero, Carla Meler-Claramonte, Marc Tobed, Jose Ignacio Tato, Pedro Castro, Maria Casasayas, Daniel Prieto-Alhambra, Francesc Xavier Avilés-Jurado

Publikováno v: Head & Neck
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Background Optimal timing for tracheotomy for critically ill COVID‐19 patients requiring invasive mechanical ventilation (IMV) is not established. Methods Multicenter prospective cohort including all COVID‐19 patients admitted to intensive care u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526b4356299ec0aaf985fa8791617de8
https://doi.org/10.1002/hed.26863