Prodromal Alzheimer’s Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer’s Pathology

Autor: Silvia de Vidania, Irene Palomares-Perez, Ana Frank-García, Takashi Saito, Takaomi C. Saido, Jonathan Draffin, María Szaruga, Lucía Chávez-Gutierrez, Miguel Calero, Miguel Medina, Francesc X. Guix, Carlos G. Dotti

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

In humans, a considerable number of the autopsy samples of cognitively normal individuals aged between 57 and 102 years have revealed the presence of amyloid plaques, one of the typical signs of AD, indicating that many of us use mechanisms that defe

Externí odkaz: https://doaj.org/article/b8f75df402f046f794db3d97e1ac37b1

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

Autor: Francesc X. Guix, Grant T. Corbett, Diana J. Cha, Maja Mustapic, Wen Liu, David Mengel, Zhicheng Chen, Elena Aikawa, Tracy Young-Pearse, Dimitrios Kapogiannis, Dennis J. Selkoe, Dominic M. Walsh

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 3, p 663 (2018)

Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer’s disease (AD). A popular theory that seeks to explain the apparent spread of neurofibrillary tangle pathology proposes that aggregated tau is passed from neuron

Externí odkaz: https://doaj.org/article/c9f24393886640fea76449554131037f

BACE1 Translation: At the Crossroads Between Alzheimer’s Disease Neurodegeneration and Memory Consolidation

Autor: Carmem Luíza Sartório, Gerard ILL-Raga, Francesc X. Guix

Publikováno v: Journal of Alzheimer's Disease Reports

Human life unfolds not only in time and space, but also in the recollection and interweaving of memories. Therefore, individual human identity depends fully on a proper access to the autobiographical memory. Such access is hindered under pathological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8648bae282068df82e0f578ac5dfc2ae
https://doi.org/10.3233/adr-180089

Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup

Autor: Héctor Peinado, Verónica Miguel, Francesc X. Guix, Santiago Lamas, Mauricio G. Martin, Álvaro Casadomé-Perales, Inés López del Castillo, Ana Marrero Capitán, Irene Palomares-Pérez, Carlos G. Dotti, Leigh Goedeke, Carlos Fernández-Hernando

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Life Science Alliance

The present study unveils the molecular mechanism through which neurons in vitro compensate age-associated proteostasis defects by increasing exosome release.
As neurons age, they show a decrease in their ability to degrade proteins and membrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3014b737fe8ca097899f6a0a36e42cb0
http://hdl.handle.net/10261/266154

Prodromal Alzheimer’s disease: Constitutive upregulation of neuroglobin prevents the initiation of Alzheimer’s pathology

Autor: Takashi Saito, Jonathan E. Draffin, Francesc X. Guix, Lucía Chávez-Gutiérrez, Takaomi C. Saido, Ana Frank-García, Miguel Medina, Carlos G. Dotti, Maria Szaruga, Irene Palomares-Pérez, Silvia de Vidania, Miguel Calero

Publikováno v: Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience

In humans, a considerable number of the autopsy samples of cognitively normal individuals aged between 57 and 102 years have revealed the presence of amyloid plaques, one of the typical signs of AD, indicating that many of us use mechanisms that defe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b71386b8d9dde4ea1cc33ff56d8680
http://hdl.handle.net/10486/695839