Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Francesc X Ruiz"'
Autor:
Firas Fadel, Yuguang Zhao, Alexandra Cousido-Siah, Francesc X Ruiz, André Mitschler, Alberto Podjarny
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154190 (2016)
Chitinases are enzymes that catalyze the hydrolysis of chitin. Human chitotriosidase (CHIT1) is one of the two active human chitinases, involved in the innate immune response and highly expressed in a variety of diseases. CHIT1 is composed of a catal
Externí odkaz:
https://doaj.org/article/a7cc8c223ec4491188c7fed2799d11a2
Autor:
Joan Giménez-Dejoz, Michal H Kolář, Francesc X Ruiz, Isidro Crespo, Alexandra Cousido-Siah, Alberto Podjarny, Oleg A Barski, Jindřich Fanfrlík, Xavier Parés, Jaume Farrés, Sergio Porté
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134506 (2015)
Human aldo-keto reductase 1B15 (AKR1B15) is a newly discovered enzyme which shares 92% amino acid sequence identity with AKR1B10. While AKR1B10 is a well characterized enzyme with high retinaldehyde reductase activity, involved in the development of
Externí odkaz:
https://doaj.org/article/1a4a15416ca5471abd2d3fbe56a1365c
Autor:
Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A. Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X. Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract HIV-1 reverse transcriptase is one of the most attractive targets for the treatment of AIDS. However, the rapid emergence of drug-resistant strains and unsatisfactory drug-like properties seriously limit the clinical application of HIV-1 non
Externí odkaz:
https://doaj.org/article/c38865deec50478fa334e921f6a1050d
Autor:
Mahta Mansouri, Shawn Rumrill, Shane Dawson, Adam Johnson, Jo-Anne Pinson, Menachem J. Gunzburg, Catherine F. Latham, Nicholas Barlow, George W. Mbogo, Paula Ellenberg, Stephen J. Headey, Nicolas Sluis-Cremer, David Tyssen, Joseph D. Bauman, Francesc X. Ruiz, Eddy Arnold, David K. Chalmers, Gilda Tachedjian
Publikováno v:
Molecules, Vol 28, Iss 7, p 3103 (2023)
Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host’s immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to prevent its progression, HIV-1 rema
Externí odkaz:
https://doaj.org/article/c7cd4c19945d4662b4ccbad1fae4b33e
Publikováno v:
Journal of Medicinal Chemistry. 66:6013-6024
Autor:
Charlotte Labrie-Cleary, Jitendra Singh, Steven Arnold, Andrew Sam, Mark Dresel, Luz Helena Alfaro Alvarado, Rebecca Roberts, Emily Fingar, Jennifer Jiang, Paul Craig, Jean Baum, Eddy Arnold, Christine Zardecki, Grace Brannigan, Julia R. Koeppe, Elizabeth M Hennen, Alan Trudeau, Joseph H Lubin, Thejasvi Venkatachalam, Jonathan K. Williams, Kevin Catalfano, Stephen K. Burley, Brian P. Hudson, Isaac Paredes, Sagar D. Khare, Yana Bromberg, Katherine See, Evan Lenkeit, Shuchismita Dutta, J. Steen Hoyer, Erika McCarthy, Michael J. Pikaart, Santiago Soto Zapata, Jenna Currier, Stephanie Laporte, Jay A. Tischfield, Siobain Duffy, Britney Dyszel, Maria Voigt, Changpeng Lu, Bonnie L. Hall, Jesse Sandberg, Kailey Martin, Aaliyah Khan, Stephen A. Mills, Sophia Staggers, Allison Rupert, Elliott M Dolan, Vidur Sarma, Lindsey Whitmore, Helen Zheng, Ashish Duvvuru, David S. Goodsell, Michael Kirsch, Melanie Ortiz-Alvarez de la Campa, Ali A Khan, Matthew Benedek, Francesc X. Ruiz, John D. Westbrook, Marilyn Orellana, Lingjun Xie, Zhuofan Shen, Baleigh Wheeler, Brea Tinsley
Publikováno v:
Proteins
bioRxiv
bioRxiv
Three-dimensional structures of SARS-CoV-2 and other coronaviral proteins archived in the Protein Data Bank were used to analyze viral proteome evolution during the first six months of the COVID-19 pandemic. Analyses of spatial locations, chemical pr
Autor:
Ruchi Yadav, Valentine V. Courouble, Sanjay K. Dey, Jerry Joe E.K. Harrison, Jennifer Timm, Jesse B. Hopkins, Ryan L. Slack, Stefan G. Sarafianos, Francesc X. Ruiz, Patrick R. Griffin, Eddy Arnold
Publikováno v:
Science Advances. 8
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic. Its ∼30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processi
X-ray crystallographic fragment screening (XCFS) uses fragment-sized molecules (∼60 – 300 Da) to access binding sites on proteins that may be inaccessible to larger drug-like molecules (>300 Da). Previous studies from our lab and others have show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d56764585fa027ce2e4e5e03d23980db
https://doi.org/10.1101/2022.10.17.512577
https://doi.org/10.1101/2022.10.17.512577
Autor:
Sanjay Kumar Dey, Francesc X. Ruiz, Ruchi Yadav, Patrick R. Griffin, Jerry Joe E. K. Harrison, Jennifer Timm, Eddy Arnold, Valentine V. Courouble
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Coronavirus (CoV) nonstructural proteins (nsps) assemble to form the replication-transcription complex (RTC) responsible for viral RNA synthesis. nsp7 and nsp8 are important cofactors of the RTC, as they interact and regulate the activity of RNA-depe
Autor:
Jie Zheng, Anthony Hoang, Steve Tuske, Kalyan Das, Erik D. Olson, Joseph D. Bauman, Bruce D. Pascal, Karin Musier-Forsyth, Eddy Arnold, Francesc X. Ruiz, Jeffrey J. DeStefano, Patrick R. Griffin
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss, Pp 116-129 (2020)
Current research in structural biology
Current research in structural biology
The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding aptamer contained 2′-O-methyl modifications and a seven base-pa