Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Francesc Ventura"'
Autor:
Joan Sala-Gaston, Eva M. Pérez-Villegas, José A. Armengol, Lettie E. Rawlins, Emma L. Baple, Andrew H. Crosby, Francesc Ventura, Jose Luis Rosa
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Sequence variants in the HERC2 gene are associated with a significant reduction in HERC2 protein levels and cause a neurodevelopmental disorder known as the HERC2-related disorder, which shares clinical features with Angelman syndrome, inclu
Externí odkaz:
https://doaj.org/article/0e471a4904ad40a3b415c0182d7f8144
Autor:
Joan Roig-Soriano, Cristina Sánchez-de-Diego, Jon Esandi-Jauregui, Sergi Verdés, Carmela R. Abraham, Assumpció Bosch, Francesc Ventura, Miguel Chillón
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The aging-protective gene α-Klotho (KL) produces two main transcripts. The full-length mRNA generates a transmembrane protein that after proteolytic ectodomain shedding can be detected in serum as processed Klotho (p-KL), and a shorter tran
Externí odkaz:
https://doaj.org/article/6d0e213469a84004ae0d9ef85a56bf58
Publikováno v:
Biology, Vol 13, Iss 4, p 221 (2024)
Dental pulp infections are common buccal diseases. When this happens, endodontic treatments are needed to disinfect and prepare the root canal for subsequent procedures. However, the lack of suitable in vitro models representing the anatomy of an imm
Externí odkaz:
https://doaj.org/article/29687a28e8d54dd3b4dddb5f648511d3
Autor:
Leonardo Pedrazza, Arturo Martinez-Martinez, Cristina Sánchez-de-Diego, José Antonio Valer, Carolina Pimenta-Lopes, Joan Sala-Gaston, Michal Szpak, Chris Tyler-Smith, Francesc Ventura, Jose Luis Rosa
Publikováno v:
Cell Death and Disease, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Bone remodeling is a continuous process between bone-forming osteoblasts and bone-resorbing osteoclasts, with any imbalance resulting in metabolic bone disease, including osteopenia. The HERC1 gene encodes an E3 ubiquitin ligase that affects
Externí odkaz:
https://doaj.org/article/f69084f257f242148b7db2221e14ea63
Autor:
Valeria Traver-Méndez, Octavi Camps-Font, Francesc Ventura, Miquel Angel Nicolau-Sansó, Carles Subirà-Pifarré, Rui Figueiredo, Eduard Valmaseda-Castellón
Publikováno v:
Materials, Vol 16, Iss 17, p 6012 (2023)
The purpose of this paper was to determine the effect of anodization on the in vitro proliferation and adhesion of immortalized human keratinocytes (HaCats) and mouse bone marrow-derived mesenchymal stem cells (BM-MSCs) in Titanium Grade 23 (Ti6Al4V
Externí odkaz:
https://doaj.org/article/72e15416f76241e2b7389a4a3b10a149
Autor:
Jesús García‐Cano, Susana Sánchez‐Tena, Joan Sala‐Gaston, Agnès Figueras, Francesc Viñals, Ramon Bartrons, Francesc Ventura, Jose Luis Rosa
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 69-86 (2020)
The p53 tumor suppressor protein is a transcription factor that plays a prominent role in protecting cells from malignant transformation. Protein levels of p53 and its transcriptional activity are tightly regulated by the ubiquitin E3 ligase MDM2, th
Externí odkaz:
https://doaj.org/article/6f9d70fe7e744495b4e32a83a146b70f
Autor:
Ruben D. de Ruiter, Bernard J. Smilde, Gerard Pals, Nathalie Bravenboer, Petra Knaus, Ton Schoenmaker, Esmée Botman, Gonzalo Sánchez-Duffhues, Maurizio Pacifici, Robert J. Pignolo, Eileen M. Shore, Marjolein van Egmond, Hans Van Oosterwyck, Frederick S. Kaplan, Edward C. Hsiao, Paul B. Yu, Renata Bocciardi, Carmen Laura De Cunto, Patricia Longo Ribeiro Delai, Teun J. de Vries, Susanne Hilderbrandt, Richard T. Jaspers, Richard Keen, Peter Koolwijk, Rolf Morhart, Jan C. Netelenbos, Thomas Rustemeyer, Christiaan Scott, Clemens Stockklausner, Peter ten Dijke, James Triffit, Francesc Ventura, Roberto Ravazzolo, Dimitra Micha, Elisabeth M. W. Eekhoff
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare progressive genetic disease effecting one in a million individuals. During their life, patients with FOP progressively develop bone in the soft tissues resulting in increasing immobility an
Externí odkaz:
https://doaj.org/article/0fd0baada54340b8bb1355163a563232
Autor:
José Antonio Valer, Cristina Sánchez‐de‐Diego, Beatriz Gámez, Yuji Mishina, José Luis Rosa, Francesc Ventura
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 9, Pp 1-13 (2019)
Abstract Heterotopic ossification (HO) is the pathological formation of ectopic endochondral bone within soft tissues. HO occurs following mechanical trauma, burns, or congenitally in patients suffering from fibrodysplasia ossificans progressiva (FOP
Externí odkaz:
https://doaj.org/article/217f501ce97048ea8484fd1bea57b8fb
Autor:
Cristina Sánchez-de-Diego, Natalia Artigas, Carolina Pimenta-Lopes, José Antonio Valer, Benjamin Torrejon, Pau Gama-Pérez, Josep A. Villena, Pablo M. Garcia-Roves, José Luis Rosa, Francesc Ventura
Publikováno v:
iScience, Vol 15, Iss , Pp 79-94 (2019)
Summary: Osteocytes, the most abundant of bone cells, differentiate while they remain buried within the bone matrix. This encasement limits their access to nutrients and likely affects their differentiation, a process that remains poorly defined. Her
Externí odkaz:
https://doaj.org/article/ca5492442f6c4bf998c1bcc21a938f51
Autor:
Cristina Sánchez-de-Diego, Leonardo Pedrazza, Carolina Pimenta-Lopes, Arturo Martinez-Martinez, Norma Dahdah, José Antonio Valer, Pablo Garcia-Roves, Jose Luis Rosa, Francesc Ventura
Publikováno v:
Redox Biology, Vol 40, Iss , Pp 101845- (2021)
Osteocytes, the most abundant bone cell type, are derived from osteoblasts through a process in which they are embedded in an osteoid. We previously showed that nutrient restriction promotes the osteocyte transcriptional program and is associated wit
Externí odkaz:
https://doaj.org/article/91cb9ac82a244c88bd8e7887ad52137a