Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Francesc Muyas"'
Autor:
Christopher Schroeder, Sergios Gatidis, Olga Kelemen, Leon Schütz, Irina Bonzheim, Francesc Muyas, Peter Martus, Jakob Admard, Sorin Armeanu-Ebinger, Brigitte Gückel, Thomas Küstner, Claus Garbe, Lukas Flatz, Christina Pfannenberg, Stephan Ossowski, Andrea Forschner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Immune checkpoint inhibitors (ICI) have significantly improved overall survival in melanoma patients. However, 60% experience severe adverse events and early response markers are lacking. Circulating tumour DNA (ctDNA) is a promising biomark
Externí odkaz:
https://doaj.org/article/e37c3f00da754d3194cbd8a961ea54c2
Autor:
Francesc Muyas, Manuel José Gómez Rodriguez, Rita Cascão, Angela Afonso, Carolin M. Sauer, Claudia C. Faria, Isidro Cortés-Ciriano, Ignacio Flores
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Telomere fusions (TFs) can trigger the accumulation of oncogenic alterations leading to malignant transformation and drug resistance. Despite their relevance in tumour evolution, our understanding of the patterns and consequences of TFs in h
Externí odkaz:
https://doaj.org/article/dc254092340a449b8ed158a0a531166d
Autor:
Roderick Bronson, Arjun Bhutkar, Peter MK Westcott, Francesc Muyas, Haley Hauck, Olivia C Smith, Nathan Sacks, Zack Ely, Alex M Jaeger, William Rideout, Daniel D Zhang, Mary Clare Beytagh, David Canner, Santiago Naranjo, Abbey Jin, Justin Patten, Amanda M Cruz, Sean-Luc Shanahan, Isidro Cortes-Ciriano, Tyler Jacks
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/f7ec3338903e4e67abbdc5790810ff7e
Autor:
Federica Scotto di Carlo, Sharon Russo, Francesc Muyas, Maria Mangini, Lorenza Garribba, Laura Pazzaglia, Rita Genesio, Flavia Biamonte, Anna Chiara De Luca, Stefano Santaguida, Katia Scotlandi, Isidro Cortés-Ciriano, Fernando Gianfrancesco
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
A detailed characterization of in vitro and in vivo phenotypes of Pfn1 knockout cells demonstrates that loss of this gene results in cytoskeletal alterations, leading to mitotic defects and genome instability.
Externí odkaz:
https://doaj.org/article/8609517adcae44f0a77a5dd393eabeec
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-14 (2020)
Abstract Background Mosaic mutations acquired during early embryogenesis can lead to severe early-onset genetic disorders and cancer predisposition, but are often undetectable in blood samples. The rate and mutational spectrum of embryonic mosaic mut
Externí odkaz:
https://doaj.org/article/e806183d477347abb71cc2063c9f5f27
Autor:
Hana Susak, Laura Serra-Saurina, German Demidov, Raquel Rabionet, Laura Domènech, Mattia Bosio, Francesc Muyas, Xavier Estivill, Geòrgia Escaramís, Stephan Ossowski
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1007784 (2021)
Rare variants are thought to play an important role in the etiology of complex diseases and may explain a significant fraction of the missing heritability in genetic disease studies. Next-generation sequencing facilitates the association of rare vari
Externí odkaz:
https://doaj.org/article/54394f1fe61b4efea767e89a29b01672
Autor:
Michaela Pogoda, Franz-Joachim Hilke, Ebba Lohmann, Marc Sturm, Florian Lenz, Jakob Matthes, Francesc Muyas, Stephan Ossowski, Alexander Hoischen, Ulrike Faust, Ilnaz Sepahi, Nicolas Casadei, Sven Poths, Olaf Riess, Christopher Schroeder, Kathrin Grundmann
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Background: This study's aim was to investigate a large cohort of dystonia patients for pathogenic and rare variants in the ATM gene, making use of a new, cost-efficient enrichment technology for NGS-based screening.Methods: Single molecule Molecular
Externí odkaz:
https://doaj.org/article/e7f0cd3231994d70b7bd7f288f807b42
Autor:
Ruoyan Li, John R. Ferdinand, Kevin W. Loudon, Georgina S. Bowyer, Sean Laidlaw, Francesc Muyas, Lira Mamanova, Joana B. Neves, Liam Bolt, Eirini S. Fasouli, Andrew R.J. Lawson, Matthew D. Young, Yvette Hooks, Thomas R.W. Oliver, Timothy M. Butler, James N. Armitage, Tev Aho, Antony C.P. Riddick, Vincent Gnanapragasam, Sarah J. Welsh, Kerstin B. Meyer, Anne Y. Warren, Maxine G.B. Tran, Grant D. Stewart, Isidro Cortés-Ciriano, Sam Behjati, Menna R. Clatworthy, Peter J. Campbell, Sarah A. Teichmann, Thomas J. Mitchell
Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and their multi-cellular interactions. To understand these dependencies within the wider microenvironment, we studied over 270,000 single-cell transcriptomes and 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158b71c82fe7745e4ec25d34b1051334
Autor:
Andrea Scelfo, Annapaola Angrisani, Bethany M. Barnes, Francesc Muyas, Carolin Sauer, Marco Grillo, Marie Dumont, Laetitia Guintini, Louisa Nelson, Isidro Cortés-Ciriano, Stephen Taylor, Jerome Dejardin, Therese Wilhelm, Daniele Fachinetti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6913afad8b2e255f13d5cbab7facf9e2
https://doi.org/10.2139/ssrn.4397184
https://doi.org/10.2139/ssrn.4397184
Autor:
Francesc Muyas, Ruoyan Li, Raheleh Rahbari, Thomas Mitchell, Sahand Hormoz, Isidro Cortes-Ciriano
Characterization of somatic mutations at single-cell resolution is essential to study cancer evolution, clonal mosaicism, and cell plasticity. However, detection of mutations in single cells remains technically challenging. Here, we describe SComatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::522bbe39edf92518de82c31cd4afc4a0
https://doi.org/10.21203/rs.3.rs-2306461/v1
https://doi.org/10.21203/rs.3.rs-2306461/v1