Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Francesc Jimenez-Altayó"'
Autor:
Tiago J. Costa, Paula R. Barros, Diego A. Duarte, Júlio A. Silva-Neto, Sara Cristina Hott, Thamyris Santos-Silva, Claudio M. Costa-Neto, Felipe V. Gomes, Eliana H. Akamine, Cameron G. McCarthy, Francesc Jimenez-Altayó, Ana Paula Dantas, Rita C. Tostes
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 324:H417-H429
The present study provides evidence that senescence induces hyperreactivity of α1-adrenoceptor-mediated contraction of the common carotid. Impairment of α1-adrenoceptor responses is linked to increased Ca2+ influx and release of COX-derived vasocon
Autor:
Èric Catalina-Hernández, Mario López-Martín, David Masnou-Sánchez, Marco Martins, Victor A. Lorenz-Fonfria, Francesc Jiménez-Altayó, Ute A. Hellmich, Hitoshi Inada, Antonio Alcaraz, Yuji Furutani, Alfons Nonell-Canals, Jose Luis Vázquez-Ibar, Carmen Domene, Rachelle Gaudet, Alex Perálvarez-Marín
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 473-482 (2024)
TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and metabolism, and is associated with pathologies like muscular dystrophy and cancer. However, TRPV2 p
Externí odkaz:
https://doaj.org/article/fec8ab2a92ba4a038f5fbb653e8b027b
Autor:
Andrea Díaz-Pérez, Belén Pérez, Gemma Manich, Julián García-Aranda, Xavier Navarro, Clara Penas, Francesc Jiménez-Altayó
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 172, Iss , Pp 116287- (2024)
Hypertension is the most prevalent modifiable risk factor for stroke and is associated with worse functional outcomes. Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid (SAHA) modulates gene expression and has emer
Externí odkaz:
https://doaj.org/article/dee5dc405d4046c4aceaa045f4e93ffa
Autor:
Isaac Rodríguez-Rovira, Angela López-Sainz, Maria Encarnación Palomo-Buitrago, Belen Pérez, Francesc Jiménez-Altayó, Victoria Campuzano, Gustavo Egea
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11293 (2023)
Redox stress is involved in the aortic aneurysm pathogenesis in Marfan syndrome (MFS). We recently reported that allopurinol, a xanthine oxidoreductase inhibitor, blocked aortopathy in a MFS mouse model acting as an antioxidant without altering uric
Externí odkaz:
https://doaj.org/article/928502543dab4514832e91d0b751efc6
Autor:
Cristina Arce, Diana Vicente, Fermí Monto, Laura González, Cristina Nuñez, Víctor M. Victor, Francesc Jiménez-Altayó, Pilar D’Ocon
Publikováno v:
International Journal of Translational Medicine, Vol 1, Iss 3, Pp 366-380 (2021)
Nitric oxide (NO) is a proangiogenic factor acting through the soluble guanylate cyclase (sGC) pathway. However, angiogenic growth increases energy demand, which may be hampered by NO inhibition of cytochrome c oxidase (CcO). Then, NO activity would
Externí odkaz:
https://doaj.org/article/e060cebda58943fda1dd46e3033af265
Autor:
Francesc Jiménez-Altayó, Anna Cabrera, Andrea Bagán, Lydia Giménez-Llort, Pilar D’Ocon, Belén Pérez, Mercè Pallàs, Carmen Escolano
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Imidazoline receptors (IR) are classified into three receptor subtypes (I1R, I2R, and I3R) and previous studies showed that regulation of I2R signaling has neuroprotective potential. In order to know if I2R has a role in modulating vascular tone in h
Externí odkaz:
https://doaj.org/article/7a2df093174d4384803e25852253ebe5
Autor:
Núria Puig, Pol Camps-Renom, Arnau Solé, Ana Aguilera-Simón, Elena Jiménez-Xarrié, Alejandro Fernández-León, Mercedes Camacho, Marina Guasch-Jiménez, Rebeca Marin, Joan Martí-Fàbregas, Alejandro Martínez-Domeño, Luis Prats-Sánchez, Francesca Casoni, Belén Pérez, Francesc Jiménez-Altayó, Jose Luis Sánchez-Quesada, Sonia Benitez
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 438 (2023)
Owing to the high risk of recurrence, identifying indicators of carotid plaque vulnerability in atherothrombotic ischemic stroke is essential. In this study, we aimed to identify modified LDLs and antioxidant enzymes associated with plaque vulnerabil
Externí odkaz:
https://doaj.org/article/b54694b1c4604ee783ba56911f014ad3
Publikováno v:
Brain Circulation, Vol 5, Iss 2, Pp 55-61 (2019)
Uric acid (UA) is a product of the catabolism of purine nucleotides, the principal constituents of DNA, RNA, and cellular energy stores, such as adenosine triphosphate. The main properties of UA include scavenging of hydroxyl radicals, superoxide ani
Externí odkaz:
https://doaj.org/article/43a60207a1b74fd8a32d0656554c7a8e
Autor:
Carmen M. Claro-Cala, Francesc Jiménez-Altayó, Sebastián Zagmutt, Rosalia Rodriguez-Rodriguez
Publikováno v:
Nutrients, Vol 14, Iss 8, p 1606 (2022)
Dietary components exert protective effects against obesity and related metabolic and cardiovascular disturbances by interfering with the molecular pathways leading to these pathologies. Dietary biomolecules are currently promising strategies to help
Externí odkaz:
https://doaj.org/article/0564a3cea95a446a81301f5ff133d7bc
Autor:
María Galán, Francesc Jiménez-Altayó
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Cardiovascular disease causes almost one third of deaths worldwide, and more than half are related to primary arterial hypertension (PAH). The occurrence of several deleterious events, such as hyperactivation of the renin–angiotensin system (RAS),
Externí odkaz:
https://doaj.org/article/28b42aacf3894f45b2c49a11fd858ea6