Mechanisms of HDL deficiency in mice overexpressing human apoA-II

Autor: Josep Julve, Joan Carles Escolà-Gil, Vicent Ribas, Francesc González-Sastre, Jordi Ordóñez-Llanos, José Luis Sánchez-Quesada, Francisco Blanco-Vaca

Publikováno v: Journal of Lipid Research, Vol 43, Iss 10, Pp 1734-1742 (2002)

To ascertain the mechanisms underlying the hypoalphalipoproteinemia present in mice overexpressing human apolipoprotein A-II (apoA-II) (line 11.1), radiolabeled HDL or apoA-I were injected into mice. Fractional catabolic rate of [3H]cholesteryl oleoy

Externí odkaz: https://doaj.org/article/65c904aa08b34b3daa71348d49cc2c97

ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance

Autor: Joan Carles Escolà-Gil, Josep Julve, Àfrica Marzal-Casacuberta, Jordi Ordóñez-Llanos, Francesc González-Sastre, Francisco Blanco-Vaca

Publikováno v: Journal of Lipid Research, Vol 42, Iss 2, Pp 241-248 (2001)

Apolipoprotein (apo)A-II is a major high density lipoprotein (HDL) protein; however, its role in lipoprotein metabolism is largely unknown. Transgenic (Tg) mice that overexpress human apoA-II present functional lecithin: cholesterol acyltransferase d

Externí odkaz: https://doaj.org/article/7d9def12fe2b432db1ca2de1a3e9ec56

Human apolipoprotein A-II is a pro-atherogenic molecule when it is expressed in transgenic mice at a level similar to that in humans: evidence of a potentially relevant species-specific interaction with diet

Autor: Joan Carles Escolà-Gil, Àfrica Marzal-Casacuberta, Josep Julve-Gil, Brian Y. Ishida, Jordi Ordóñez-Llanos, Lawrence Chan, Francesc González-Sastre, Francisco Blanco-Vaca

Publikováno v: Journal of Lipid Research, Vol 39, Iss 2, Pp 457-462 (1998)

We report on the effect of human apolipoprotein (apo) A-II transgene expression on atherosclerosis susceptibility in two transgenic lines (25.3 and 11.1) whose plasma human apoA-II concentrations (∼23 and 96 mg/dl, respectively) span the normal ran

Externí odkaz: https://doaj.org/article/f6c7bff98e3446819d9b9c2fd18aee03

Genetic Mutations in a Spanish Population with Chronic Pancreatitis

Autor: Laia Comas, Elia Ripoll, Francesc González-Sastre, Josefina Mora, Patricia Gonçalves, Antoni Farré, J. M. Queralto

Publikováno v: PANCREATOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Background/Aims: Mutations in the PRSS1 and the SPINK1 genes have variably been associated with alcohol-related, idiopathic and hereditary chronic pancreatitis (CP). The aim of this study was to determine for the first time the significance of PRSS1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f802c3e069032e9d6f56f64b2aca88
https://doi.org/10.1159/000181177

Platelet-Activating Factor Acetylhydrolase Is Mainly Associated With Electronegative Low-Density Lipoprotein Subfraction

Autor: Francisco Blanco-Vaca, José Luis Sánchez-Quesada, Francesc González-Sastre, Sonia Benitez, Vicent Ribas, Jordi Ordóñez-Llanos, Oscar Jorba

Publikováno v: Circulation. 108:92-96

Background— Electronegative LDL [LDL(−)], a modified subfraction of LDL present in plasma, induces the release of interleukin-8 and monocyte chemotactic protein-1 from cultured endothelial cells. Methods and Results— We demonstrate that platele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86258895f9ce76336efb8c0b0b5262a8
https://doi.org/10.1161/01.cir.0000072791.40232.8f