Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Francesc, Posas"'
Autor:
Maximilian Mosbacher, Sung Sik Lee, Gilad Yaakov, Mariona Nadal-Ribelles, Eulàlia de Nadal, Frank van Drogen, Francesc Posas, Matthias Peter, Manfred Claassen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cellular decision making often builds on ultrasensitive MAPK pathways. The phosphorylation mechanism of MAP kinase has so far been described as either distributive or processive, with distributive mechanisms generating ultrasensitivity in th
Externí odkaz:
https://doaj.org/article/0960943550834387b65d093a11cd7dac
Autor:
Carlos Jiménez, Roberta Antonelli, Mariona Nadal-Ribelles, Laura Devis-Jauregui, Pablo Latorre, Carme Solé, Marc Masanas, Adrià Molero-Valenzuela, Aroa Soriano, Josep Sánchez de Toledo, David Llobet-Navas, Josep Roma, Francesc Posas, Eulàlia de Nadal, Soledad Gallego, Lucas Moreno, Miguel F. Segura
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-17 (2022)
Abstract Background Epigenetic programming during development is essential for determining cell lineages, and alterations in this programming contribute to the initiation of embryonal tumour development. In neuroblastoma, neural crest progenitors blo
Externí odkaz:
https://doaj.org/article/eccd23a922d54a24b80304022f4ce153
Autor:
Pol Picón-Pagès, Mònica Bosch-Morató, Laia Subirana, Francisca Rubio-Moscardó, Biuse Guivernau, Hugo Fanlo-Ucar, Melisa Ece Zeylan, Simge Senyuz, Víctor Herrera-Fernández, Rubén Vicente, José M. Fernández-Fernández, Jordi García-Ojalvo, Attila Gursoy, Ozlem Keskin, Baldomero Oliva, Francesc Posas, Eulàlia de Nadal, Francisco J. Muñoz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1278 (2023)
Alzheimer’s disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried out a genome-wide s
Externí odkaz:
https://doaj.org/article/b0b07a45c8f94114a63f5d18bd3111dc
Autor:
Delphine Aymoz, Carme Solé, Jean‐Jerrold Pierre, Marta Schmitt, Eulàlia de Nadal, Francesc Posas, Serge Pelet
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 4, Pp 1-13 (2018)
Abstract During development, morphogens provide extracellular cues allowing cells to select a specific fate by inducing complex transcriptional programs. The mating pathway in budding yeast offers simplified settings to understand this process. Phero
Externí odkaz:
https://doaj.org/article/9f1fddb44a8e442ea20d730e29350fe9
Autor:
Alba Duch, Berta Canal, Sonia I. Barroso, María García-Rubio, Gerhard Seisenbacher, Andrés Aguilera, Eulàlia de Nadal, Francesc Posas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
During S phase of the cell cycle, transcription and replication need to be coordinated in order to avoid conflicts leading to potential genomic instability. Here, the authors find that Mrc1 integrates signals from different kinases to regulate replic
Externí odkaz:
https://doaj.org/article/890cd55d01074eb4acae28ff6220fd5b
Autor:
David Canadell, Nicolás Ortiz-Vaquerizas, Sira Mogas-Diez, Eulàlia de Nadal, Javier Macia, Francesc Posas
Publikováno v:
Nucleic Acids Research. 50:12578-12595
The use of synthetic biological circuits to deal with numerous biological challenges has been proposed in several studies, but its implementation is still remote. A major problem encountered is the complexity of the cellular engineering needed to ach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f89463f457015ecc7a238ec02a8435
https://doi.org/10.1093/nar/gkac1120
https://doi.org/10.1093/nar/gkac1120
Autor:
Ya-Lan Chang, Shun-Fu Tseng, Yu-Ching Huang, Zih-Jie Shen, Pang-Hung Hsu, Meng-Hsun Hsieh, Chia-Wei Yang, Silvia Tognetti, Berta Canal, Laia Subirana, Chien-Wei Wang, Hsiao-Tan Chen, Chi-Ying Lin, Francesc Posas, Shu-Chun Teng
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
A G1 cell cycle regulatory kinase Cip1 has been identified in budding yeast but how this is regulated is unclear. Here the authors identify cell cycle (Mcm1) and stress-mediated (Msn 2/4) transcription factors as regulating Cip1, causing stress induc
Externí odkaz:
https://doaj.org/article/471f7f9a1954498791ddcc5b39f8dc56
Autor:
Klement Stojanovski, Tony Ferrar, Hannah Benisty, Friedemann Uschner, Javier Delgado, Javier Jimenez, Carme Solé, Eulalia de Nadal, Edda Klipp, Francesc Posas, Luis Serrano, Christina Kiel
Publikováno v:
Cell Reports, Vol 19, Iss 1, Pp 136-149 (2017)
The understanding of interaction dynamics in signaling pathways can shed light on pathway architecture and provide insights into targets for intervention. Here, we explored the relevance of kinetic rate constants of a key upstream osmosensor in the y
Externí odkaz:
https://doaj.org/article/5b31b98c109b4be7825a4ebde1dd8571
Autor:
Christian Linke, Anastasia Chasapi, Alberto González-Novo, Istabrak Al Sawad, Silvia Tognetti, Edda Klipp, Mart Loog, Sylvia Krobitsch, Francesc Posas, Ioannis Xenarios, Matteo Barberis
Publikováno v:
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-12 (2017)
Cell cycle control: Order in time achieved by dynamic coupling A dynamic coupling of cyclin-dependent kinase with transcription factors in yeast offers insights into the timely cell cycle progression. An international team lead by Matteo Barberis fro
Externí odkaz:
https://doaj.org/article/b97661edfbb74ad691b7c34f9005b5f8
Autor:
Mariona Nadal-Ribelles, Saiful Islam, Wu Wei, Pablo Latorre, Michelle Nguyen, Eulàlia de Nadal, Francesc Posas, Lars Steinmetz
Publikováno v:
Bio-Protocol, Vol 9, Iss 17 (2019)
Single-cell RNA-seq (scRNA-seq) has become an established method for uncovering the intrinsic complexity within populations. Even within seemingly homogenous populations of isogenic yeast cells, there is a high degree of heterogeneity that originates
Externí odkaz:
https://doaj.org/article/b9980906e8e841aeabc8c51ccb5e49bd