A novel detection method of cleaved plasma high‐molecular‐weight kininogen reveals its correlation with Alzheimer's pathology and cognitive impairment

Autor: Hitomi Yamamoto‐Imoto, Daria Zamolodchikov, Zu‐Lin Chen, S. Lloyd Bourne, Syeda Rizvi, Pradeep Singh, Erin H. Norris, Frances Weis‐Garcia, Sidney Strickland

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 480-489 (2018)

Abstract Introduction Accumulation of β‐amyloid is a pathological hallmark of Alzheimer's disease (AD). β‐Amyloid activates the plasma contact system leading to kallikrein‐mediated cleavage of intact high‐molecular‐weight kininogen (HKi)

Externí odkaz: https://doaj.org/article/736a60c21d2c42abb28c56a2c65bc95c

Data from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines

Autor: Frank Winkler, Frances Weis-Garcia, Adina Vultur, Damir Varešlija, Leonie S. Young, Frits Thorsen, Patricia S. Steeg, Nicola R. Sibson, Josh Neman, Joan Massague, Mihaela Lorger, Johanna A. Joyce, Rakesh K. Jain, Sheri L. Holmen, Meenhard Herlyn, Brunilde Gril, Dai Fukumura, Gino B. Ferraro, Neta Erez, Diana M. Cittelly, Paula D. Bos, Adrienne Boire, Amos Bairoch, Carey K. Anders, Amanda E.D. Van Swearingen, Manuel Valiente

Spread of cancer to the brain remains an unmet clinical need in spite of the increasing number of cases among patients with lung, breast cancer, and melanoma most notably. Although research on brain metastasis was considered a minor aspect in the pas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b42c81539e428456b11ca0d14895476
https://doi.org/10.1158/0008-5472.c.6512188

Survey on Scientific Shared Resource Rigor and Reproducibility

Autor: Frances Weis-Garcia, Sheenah Mische, Katia Sol-Church, Belynda Hicks, Susan M. Meyn, Rebecca L. Hegstad-Davies, Peter Lopez, Robert H. Carnahan, Lisa D. White, Nancy C. Fisher, Kevin L. Knudtson

Publikováno v: Journal of Biomolecular Techniques : JBT. 30:36-44

Shared scientific resources, also known as core facilities, support a significant portion of the research conducted at biomolecular research institutions. The Association of Biomolecular Resource Facilities (ABRF) established the Committee on Core Ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfc8721e3ac2493b6ea94183059dd4d
https://doi.org/10.7171/jbt.19-3003-001

A novel detection method of cleaved plasma high‐molecular‐weight kininogen reveals its correlation with Alzheimer's pathology and cognitive impairment

Autor: Pradeep K. Singh, Sidney Strickland, Daria Zamolodchikov, Frances Weis-Garcia, Syeda Rizvi, Zu-Lin Chen, S. Lloyd Bourne, Erin H. Norris, Hitomi Yamamoto-Imoto

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 480-489 (2018)
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Introduction Accumulation of β-amyloid is a pathological hallmark of Alzheimer's disease (AD). β-Amyloid activates the plasma contact system leading to kallikrein-mediated cleavage of intact high-molecular-weight kininogen (HKi) to cleaved high-mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b303a91680fc691fff9123175c8db9b0
https://doi.org/10.1016/j.dadm.2018.06.008

Abstract 1776: High-affinity anti-galectin-3 antibodies targeting oncogenic properties in serous ovarian cancer

Autor: Frances Weis-Garcia, Noah Feit, Sven J. Walderich, Dharmarao Thapi, Marina Stasenko, David Spriggs, Thomas D. White

Publikováno v: Cancer Research. 78:1776-1776

Objective: Galectin-3 (LGALS3) regulates the interaction of surface proteins with the extracellular membrane domain and mediates a signal cascade leading to invasion, oncogene activation and growth. We targeted LGALS3 cancer promotion by developing h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dc3b56119ca3a33b3efc4af91d86e48
https://doi.org/10.1158/1538-7445.am2018-1776