Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Frances W.J. Beck"'
Autor:
Steven C. Marks, Hayward S. Penny, Ananda S. Prasad, Walter A. Salwen, Falah Shamsa, Frances W.J. Beck, Joseph Kaplan, Robert H. Mathog
Publikováno v:
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 116(6)
In this study we have assessed zinc status and zinc-dependent cell-mediated immune functions (interleukin-2 production by mononuclear cells, natural killer cell lytic activity, and interleukin-1β production by mononuclear cells) in adult patients wi
Autor:
Fazlul H. Sarkar, Irfana Muqbil, S.M. Hadi, Bin Bao, Asfar S. Azmi, Frances W.J. Beck, Ramzi M. Mohammad
Publikováno v:
Current Pharmaceutical Design. 18:1645-1654
Resveratrol found in fruits, vegetables and beverages such as red wine, has been extensively evaluated for its anticardiovascular disease and cancer preventive effects. Even though studies have demonstrated its anti-tumor effects, there is still no c
Publikováno v:
Nutrition. 27:816-823
Objective Chronic generation of inflammatory cytokines and reactive oxygen species are implicated in atherosclerosis, aging, cancers, and other chronic diseases. We hypothesized that zinc induces A20 in premonocytic, endothelial, and cancer cells, an
Autor:
Asfar S. Azmi, Tony F. Shields, Zhiwei Wang, Bin Bao, Sanjeev Banerjee, Ma'in Y. Maitah, Fazlul H. Sarkar, Frances W.J. Beck, Philip A. Philip, Ramzi M. Mohammad, Shadan Ali, Minsig Choi
Publikováno v:
Oncotarget
Asfar S. Azmi 1 , Sanjeev Banerjee 1 , Shadan Ali 1 , Zhiwei Wang 1 , Bin Bao 1 , Frances W.J. Beck 2 , Main Maitah 2 , Minsig Choi 2 , Tony F. Shields 2 , Philip A. Philip 2 , Fazlul H. Sarkar 1 , Ramzi M. Mohammad 2 1 Department of Pathology, Wayne
Autor:
Ginny Bao, Shadan Ali, Bin Bao, Fazlul H. Sarkar, Frances W.J. Beck, Ananda S. Prasad, Tapinder Singh
Publikováno v:
Biochemical and Biophysical Research Communications. 407:703-707
Zinc deficiency impairs cellular immunity. Up-regulation of mRNA levels of IFN-γ, IL-12Rβ2, and T-bet are essential for Th1 differentiation. We hypothesized that zinc increases Th1 differentiation via up-regulation of IFN-γ and T-bet expression. T
Publikováno v:
Current Pharmaceutical Design. 17:640-652
The discovery of small molecule inhibitors of HDM2-p53 interaction is considered one of the most significant therapeutic developments in the area p53 research. Intensive work on different classes of HDM2 inhibitors has proven their therapeutic utilit
Autor:
Dajun Yang, Shaomeng Wang, Fazlul H. Sarkar, Frances W.J. Beck, Sanjeev Banerjee, Asfar S. Azmi, Ramzi M. Mohammad, Philip A. Philip, Zhiwei Wang
Publikováno v:
Oncogene
Zinc has a crucial role in the biology of p53 in that p53 binds to DNA through a structurally complex domain stabilized by zinc atom. The p53 negative regulator MDM2 protein also carries a C-terminal RING domain that coordinates two zinc atoms, which
Autor:
Frances W.J. Beck, James T. Fitzgerald, Ginny W Bao, Ananda S. Prasad, Tapinder Singh, Lavoisier J Cardozo, Diane Snell, Bin Bao
Publikováno v:
The American Journal of Clinical Nutrition. 91:1634-1641
Background: Chronic inflammation and oxidative stress are common risk factors for atherosclerosis. Zinc is an essential micronutrient that can function as an antiinflammatory and antioxidative agent, and as such, it may have atheroprotective properti
Publikováno v:
Nutrition and Cancer. 61:879-887
Essentiality of zinc for humans was discovered 45 yr ago. Deficiency of zinc is prevalent world wide in developing countries and may affect nearly 2 billion subjects. The major manifestations of zinc deficiency include growth retardation, hypogonadis
Publikováno v:
Translational Research. 148:325-333
A nutritional deficiency of zinc in humans is widespread in the developing world, and a conditioned zinc deficiency is observed in many diseased states, the elderly population, and pregnant women of both developed and developing nations. It was recen