Systematic review and meta-analysis of cell therapy for COVID-19: global clinical trial landscape, published safety/efficacy outcomes, cell product manufacturing and clinical delivery

Autor: Pedro S. Couto, Nada Al-Arawe, Igor S. Filgueiras, Dennyson L. M. Fonseca, Irene Hinterseher, Rusan A. Catar, Raghavan Chinnadurai, Alexey Bersenev, Otávio Cabral-Marques, Guido Moll, Frances Verter

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

During the pandemic of severe respiratory distress syndrome coronavirus 2 (SARS-CoV2), many novel therapeutic modalities to treat Coronavirus 2019 induced disease (COVID-19) were explored. This study summarizes 195 clinical trials of advanced cell th

Externí odkaz: https://doaj.org/article/3453d8fc709a4db7aa610374d87f1899

Development of COVID‐19 Therapies from Birthing Tissues and Cord Blood

Autor: Frances Verter, Pedro Silva Couto

Publikováno v: Stem Cells Translational Medicine, Vol 9, Iss S1, Pp S15-S15 (2020)

Externí odkaz: https://doaj.org/article/589c693decca4191aba3333b4e493853

First decade of clinical trials and published studies with mesenchymal stromal cells from umbilical cord tissue

Autor: Pedro Silva Couto, Alexey Bersenev, Gocha Shatirishvili, Frances Verter

Publikováno v: Regenerative Medicine. 14:309-319

Aim: This is the first analysis of both clinical trials and published studies that employ umbilical cord mesenchymal stromal cells, for the decade 2007–2017. Materials & methods: Searching international databases, we found 178 registered trials and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de0b1b215547f569aa99d55b58697c1
https://doi.org/10.2217/rme-2018-0171

Expansion of human mesenchymal stem/stromal cells (hMSCs) in bioreactors using microcarriers: lessons learnt and what the future holds

Autor: Alexey Bersenev, Marco Rotondi, Frances Verter, Alvin W. Nienow, P. Silva Couto, Qasim A. Rafiq, Christopher J. Hewitt

Publikováno v: Biotechnology advances. 45

Human mesenchymal stem/stromal cells (hMSCs) present a key therapeutic cellular intervention for use in cell and gene therapy (CGT) applications due to their immunomodulatory properties and multi-differentiation capability. Some of the indications wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5687b16f17781b0e1faff8de2a10387
https://pubmed.ncbi.nlm.nih.gov/32980437

List of Contributors

Autor: Mohammed Ali, Julie Allickson, Graça Almeida-Porada, Eleni Antoniadou, Rita Anzalone, Anthony Atala, Bogna Badyra, Carolina Balbi, Karen K. Ballen, Emily C. Beck, Gail E. Besner, Sveva Bollini, Cesar V. Borlongan, Robert Briddell, Anna Cargnoni, James E. Carroll, Renzo Cecere, Kyle Cetrulo, Lawrence W. Chamley, Xiaojuan Chen, Ramon E. Coronado, Pedro S. Couto, Charles S. Cox, Stefano Da Sacco, Anna L. David, Paolo de Coppi, Roger E. De Filippo, William Fodor, Timothy Ganey, Aldo Gerbino, Kate F. Girard, Vivian A. Guedes, Ye Guo, Zhongchao Han, Zhibo Han, Richard L. Haspel, Cristina Ivan, Jeffrey G. Jacot, Joanna L. James, Kashif Khan, Kiarash Khosrotehrani, Thomas J. Koob, Morey Kraus, Peter Kruzliak, Akshita Kumar, Giampiero La Rocca, Jean-Jacques Lataillade, Steven T. Leung, Jeremy J. Lim, Michael Grant Liska, Frank Litkenhaus, Fang Liu, Tianfeng Liu, Marta Magatti, Marcin Majka, Georges Makhoul, Sherwin Mashkouri, Christopher McCulloh, Susan R. McGlashan, Toshio Miki, Sean V. Murphy, Elliot Neal, Racheli Ofir, Radka Opatrilova, Bo Overschmidt, Ornella Parolini, Jatin Patel, Juliette Peltzer, Astgik Petrosyan, Martina Piccoli, Christopher D. Porada, Daniel A. Porada, Michela Pozzobon, Gautam Rao, Noa Sher, James L. Sherley, Antonietta R. Silini, Pedro Silva Couto, Aleksander Skardal, Sindhu Subramaniam, Maciej Sułkowski, Rouzbeh R. Taghizadeh, Harry T. Temple, Nilses Vera, Frances Verter, Fran Verter, Valentina Villani, Shuchun Wang, Wendy Weston, John R. Wetherell, Wenyu Yang, Jiayuan Zhang, Yu Zhou, Xiaofan Zhu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58c5de6a290c56f6048cb20132023496
https://doi.org/10.1016/b978-0-12-812015-6.01002-5