Výsledky vyhledávání - "Frances V. Wells"

Clevudine Therapy with Vaccine Inhibits Progression of Chronic Hepatitis and Delays Onset of Hepatocellular Carcinoma in Chronic Woodchuck Hepatitis Virus Infection

Autor: Paul J. Cote, Ilia Toshkov, John L. Gerin, Stephan Menne, Bud C. Tennant, Baldwin Bh, Brent E. Korba, Frances V. Wells

Publikováno v: Antiviral Therapy. 9:937-952

We examined a rational approach to therapy of chronic hepatitis B virus (HBV) infection that utilized the reduction of viral load combined with appropriately timed immune modulation/stimulation. In a placebo-controlled study, chronic woodchuck hepati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bbf1518fbac25ea2e34ed6055681be0
https://doi.org/10.1177/135965350400900611

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Natural history of experimental woodchuck hepatitis virus infection: molecular virologic features of the pancreas, kidney, ovary, and testis

Autor: Paul J. Cote, B C Tennant, John L. Gerin, B Baldwin, T L Brown, Frances V. Wells, Brent E. Korba, H Steinberg

Publikováno v: Journal of Virology. 64:4499-4506

The kinetic patterns of woodchuck hepatitis virus (WHV) infection were monitored in the pancreas, kidneys, ovaries, and testes. Groups of woodchucks experimentally infected with a standardized inoculum of WHV were sacrificed at different times over a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605c1883cdb7903a823d54738199c8c6
https://doi.org/10.1128/jvi.64.9.4499-4506.1990

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Riboprobe assay for HDV RNA: A sensitive method for the detection of the HDV genome in clinical serum samples

Autor: Bergmann Kf, Bahige M. Baroudy, Mario Rizzetto, Antonina Smedile, Frances V. Wells, John L. Gerin, Robert H. Purcell, Ferruccio Bonino

Publikováno v: Journal of Medical Virology. 30:20-24

We have used a new hybridization assay for the detection of the genome of hepatitis delta virus (HDV) in serum using a strand-specific RNA probe obtained by transcription of a recombinant riboprobe. This assay was tested on a panel of 30 sera from HB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7651d9e12162efe6e3aaf2c01568d68c
https://doi.org/10.1002/jmv.1890300105

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Clevudine therapy with vaccine inhibits progression of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic woodchuck hepatitis virus infection

Autor: Brent E, Korba, Paul J, Cote, Stephan, Menne, Ilia, Toshkov, Betty H, Baldwin, Frances V, Wells, Bud C, Tennant, John L, Gerin

Publikováno v: Antiviral therapy. 9(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d228ab1dc7fabfd3b924e87ee2a36f5c
https://pubmed.ncbi.nlm.nih.gov/15651753

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Enhancement of antiviral activity against hepatitis C virus in vitro by interferon combination therapy

Autor: Jo Ann Rinaudo, Chiaki Okuse, Brent E. Korba, Frances V. Wells, Kristine Farrar

Publikováno v: Antiviral research. 65(1)

Alpha, beta, and gamma interferons (IFN-alpha, IFN-beta, IFN-gamma) have been shown to be effective inhibitors of HCV replication in human cell lines carrying HCV replicons. To help define the divergent cellular processes involved in the control of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f405494d7ea4b479c8b99e26db4b9b0a
https://pubmed.ncbi.nlm.nih.gov/15652968

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Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax)

Autor: Frances V. Wells, Baldwin Bh, Chung K. Chu, Paul J. Cote, John L. Gerin, James R. Jacob, Bud C. Tennant, William E. Hornbuckle, Ilia Toshkov, Simon F. Peek, Brent E. Korba

Publikováno v: Hepatology (Baltimore, Md.). 33(1)

L: -FMAU [1-(2-fluoro-5-methyl-beta,L-arabinofuranosyl) uracil] has been shown to be an effective inhibitor of hepatitis B virus (HBV) and duck hepatitis B virus replication in cell culture and duck hepatitis B virus replication in acutely infected P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c39e6b36a5072921283989b0984e447
https://pubmed.ncbi.nlm.nih.gov/11124844

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An Ultraviolet-Sensitive RNA Structural Element in a Viroid-Like Domain of the Hepatitis Delta Virus

Autor: Andrea D. Branch, John L. Gerin, Frances V. Wells, Bahige M. Baroudy, Bonnie J. Benenfeld, Hugh D. Robertson

Publikováno v: Science. 243:649-652

The RNA genome of the hepatitis delta virus (HDV) appears to be made up of two parts: a small domain with a high degree of sequence conservation and structural features likely to promote replication; plus a second, larger domain that is less conserve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c82e368d366568085c07caa7ef56be
https://doi.org/10.1126/science.2492676

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Systemic distribution of woodchuck hepatitis virus in the tissues of experimentally infected woodchucks

Autor: Frances V. Wells, Bud C. Tennant, John L. Gerin, Richard Clarke, Eric J. Gowans, Brent E. Korba

Publikováno v: Virology. 165:172-181

To better assess the extent of the tissue tropism of mammalian hepadnaviruses, 10 tissues from each of six woodchucks were examined for the presence and state of woodchuck hepatitis virus (WHV) nucleic acids 15 months after experimental WHV infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f91de2c1f3092020201460f5c39b61a
https://doi.org/10.1016/0042-6822(88)90670-8

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Application Of Nucleic acid hybridization to the hepatitis δ virus research

Autor: Antonina Smedile, John L. Gerin, Frances V. Wells, Mario Rizzetto, Bahige M. Baroudy, Ferruccio Bonino, Giorgio Verme

Publikováno v: La Ricerca in Clinica e in Laboratorio. 18:143-160

Cloning and sequencing of the genome of hepatitis delta virus (HDV) represented a remarkable progress in the knowledge of HDV infection and made available cDNA and RNA probes which can be successfully used to identify HDV-RNA in biological specimens.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64445dcd12a23d2c2b0063ca6bbb1c96
https://doi.org/10.1007/bf02918880

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Lymphoid cells in the spleens of woodchuck hepatitis virus-infected woodchucks are a site of active viral replication

Autor: Frances V. Wells, Bud C. Tennant, Paul J. Cote, John L. Gerin, Brent E. Korba

Publikováno v: Journal of Virology. 61:1318-1324

Lymphoid cells were purified from the spleens of 15 woodchucks and examined for the presence of woodchuck hepatitis virus (WHV). Lymphoid cells from the spleens of eight of eight chronically infected animals contained high levels of WHV RNA and DNA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc42ff5bc0c77a14c560f39db30c384
https://doi.org/10.1128/jvi.61.5.1318-1324.1987

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