Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Frances V. Sjaastad"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The kinase Csk is the primary negative regulator of the Src-family kinases (SFKs, e.g., Lck, Fyn, Lyn, Hck, Fgr, Blk, Yes), phosphorylating a tyrosine on the SFK C-terminal tail that mediates autoinhibition. Csk also binds phosphatases, incl
Externí odkaz:
https://doaj.org/article/ce8d2dc1947c4343a6d13920a24a2a34
Autor:
Frances V. Sjaastad, Tamara A. Kucaba, Thamotharampillai Dileepan, Whitney Swanson, Cody Dail, Javier Cabrera-Perez, Katherine A. Murphy, Vladimir P. Badovinac, Thomas S. Griffith
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Patients who survive sepsis display prolonged immune dysfunction and heightened risk of secondary infection. CD4 T cells support a variety of cells required for protective immunity, and perturbations to the CD4 T cell compartment can decrease overall
Externí odkaz:
https://doaj.org/article/381e1ca65e034ee2bd014a899da9f2a4
Autor:
Matthew A. Huggins, Frances V. Sjaastad, Mark Pierson, Tamara A. Kucaba, Whitney Swanson, Christopher Staley, Alexa R. Weingarden, Isaac J. Jensen, Derek B. Danahy, Vladimir P. Badovinac, Stephen C. Jameson, Vaiva Vezys, David Masopust, Alexander Khoruts, Thomas S. Griffith, Sara E. Hamilton
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1729-1743.e5 (2019)
Summary: Microbial exposures can define an individual’s basal immune state. Cohousing specific pathogen-free (SPF) mice with pet store mice, which harbor numerous infectious microbes, results in global changes to the immune system, including increa
Externí odkaz:
https://doaj.org/article/616bd8deb02f4133864eeba116b467a3
Autor:
Frances V. Sjaastad, Stephanie A. Condotta, Jessica A. Kotov, Kathryn A. Pape, Cody Dail, Derek B. Danahy, Tamara A. Kucaba, Lorraine T. Tygrett, Katherine A. Murphy, Javier Cabrera-Perez, Thomas J. Waldschmidt, Vladimir P. Badovinac, Thomas S. Griffith
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Immunosuppression is one hallmark of sepsis, decreasing the host response to the primary septic pathogens and/or secondary nosocomial infections. CD4 T cells and B cells are among the array of immune cells that experience reductions in number and fun
Externí odkaz:
https://doaj.org/article/73ff433ade8f44b69e31d8fdbc0c3732
Autor:
Frances V. Sjaastad, Matthew A. Huggins, Erin D. Lucas, Cara Skon-Hegg, Whitney Swanson, Matthew D. Martin, Oscar C. Salgado, Julie Xu, Mark Pierson, Thamotharampillai Dileepan, Tamara A. Kucaba, Sara E. Hamilton, Thomas S. Griffith
Publikováno v:
The Journal of Immunology. 209:2149-2159
Successful vaccination strategies offer the potential for lifelong immunity against infectious diseases and cancer. There has been increased attention regarding the limited translation of some preclinical findings generated using specific pathogen-fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872f7a37664b90156082e0ec32861d51
https://doi.org/10.4049/jimmunol.2200324
https://doi.org/10.4049/jimmunol.2200324
Autor:
Samantha N. Jensen, Vladimir P. Badovinac, Thomas S. Griffith, Isaac J. Jensen, Thamothrampillai Dileepan, Ashutosh K. Mangalam, Katherine N. Gibson-Corley, Frances V. Sjaastad
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Evaluation of sepsis-induced immunoparalysis has highlighted how decreased lymphocyte number/function contribute to worsened infection/cancer. Yet, an interesting contrast exists with autoimmune disease development, wherein diminishing pathogenic eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3b2c9432f3b9ceb17c6bcdb230ddaa
http://europepmc.org/articles/PMC7721438
http://europepmc.org/articles/PMC7721438
Autor:
Isaac J. Jensen, Vladimir P. Badovinac, Derek B. Danahy, John T. Harty, Thomas S. Griffith, Frances V. Sjaastad, Scott M. Anthony, Stephanie van de Wall, Steven J Moioffer
Publikováno v:
J Immunol
Sepsis reduces the number and function of memory CD8 T cells within the host, contributing to the long-lasting state of immunoparalysis. Interestingly, the relative susceptibility of memory CD8 T cell subsets to quantitative/qualitative changes diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a172f91793ed86d90d0cb552de103a70
https://pubmed.ncbi.nlm.nih.gov/34479943
https://pubmed.ncbi.nlm.nih.gov/34479943
Autor:
Vladimir P. Badovinac, Frances V. Sjaastad, Isaac J. Jensen, Roger R. Berton, Thomas S. Griffith
Publikováno v:
Curr Protoc Immunol
Numerous models are available for the preclinical study of sepsis, and they fall into one of three general categories: (1) administration of exogenous toxins (e.g., lipopolysaccharide, zymosan), (2) virulent bacterial or viral challenge, and (3) host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547c82aedebe8d17091a56c3bcf77af1
https://pubmed.ncbi.nlm.nih.gov/33027848
https://pubmed.ncbi.nlm.nih.gov/33027848
Autor:
Samantha N. Jensen, Frances V. Sjaastad, Ashutosh K. Mangalam, Isaac J. Jensen, Vladimir P. Badovinac, Thomas S. Griffith, Thamothrampillai Dileepan, Katherine N. Gibson-Corley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7b6bf09a1daee1cee7fe7108d67f52d
https://doi.org/10.7554/elife.55800.sa2
https://doi.org/10.7554/elife.55800.sa2
Autor:
Tamara A. Kucaba, Britnie R. James, Thomas S. Griffith, Andrew Wilber, Frances V. Sjaastad, Katherine A. Murphy, Hyunjoon Kim, Erik L. Brincks, Streamson C. Chua
Publikováno v:
The Journal of Immunology. 201:1837-1841
Various malignancies are reproducibly cured in mouse models, but most cancer immunotherapies show objective responses in a fraction of treated patients. One reason for this disconnect may be the use of young, lean mice lacking immune-altering comorbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81f756bbf9a1ab9f9910800c08fe769
https://doi.org/10.4049/jimmunol.1701738
https://doi.org/10.4049/jimmunol.1701738