Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Frances V. Fuller-Pace"'
Autor:
Julien M. D. Legrand, Ai-Leen Chan, Hue M. La, Fernando J. Rossello, Minna-Liisa Änkö, Frances V. Fuller-Pace, Robin M. Hobbs
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Sustained sperm production is dependent on activity of undifferentiated spermatogonia. Here, the authors demonstrate an essential role for RNA helicase DDX5 in maintenance of spermatogonia in adults through control of gene transcription plus RNA proc
Externí odkaz:
https://doaj.org/article/852498ee4d314917b02f782d466e190b
Autor:
Gilles Gadea, Nikola Arsic, Kenneth Fernandes, Alexandra Diot, Sébastien M Joruiz, Samer Abdallah, Valerie Meuray, Stéphanie Vinot, Christelle Anguille, Judit Remenyi, Marie P Khoury, Philip R Quinlan, Colin A Purdie, Lee B Jordan, Frances V Fuller-Pace, Marion de Toledo, Maïlys Cren, Alastair M Thompson, Jean-Christophe Bourdon, Pierre Roux
Publikováno v:
eLife, Vol 5 (2016)
TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, base
Externí odkaz:
https://doaj.org/article/f581c63f2c83491e9dc7660202f2310e
Autor:
Minna-Liisa Änkö, Frances V. Fuller-Pace, Hue M. La, Fernando J. Rossello, Robin M. Hobbs, Julien M. D. Legrand, Ai-Leen Chan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Nature Communications
Nature Communications
Mammalian spermatogenesis is sustained by mitotic germ cells with self-renewal potential known as undifferentiated spermatogonia. Maintenance of undifferentiated spermatogonia and spermatogenesis is dependent on tightly co-ordinated transcriptional a
Autor:
Frances V. Fuller-Pace, Sarah Vinnicombe, Shelley A. Waugh, Katrin Brauer, Andrew Evans, Jane Macaskill, Lee B. Jordan, Colin A. Purdie, Alastair M. Thompson, P Whelehan
Publikováno v:
Senologie - Zeitschrift für Mammadiagnostik und -therapie. 15:229-237
Prediction of pathological complete response (pCR) of primary breast cancer to neoadjuvant chemotherapy (NACT) may influence planned surgical approaches in the breast and axilla. The aim of this project is to assess the value of interim shear wave el
Autor:
Simak Ali, Frances V. Fuller-Pace, Laki Buluwela, Luca Magnani, Naveenan Navaratnam, Roslin Russell, Carlos Caldas, Jason S. Carroll, Anna Maria Ochocka, Manikandan Periyasamy, Van T. M. Nguyen, Hetal Patel, Ross S. Thomas, Chun-Fui Lai, Wilbert Zwart, Alison Harrod, Balázs Győrffy, Ekaterina Nevedomskaya, Judit Remenyi, R. Charles Coombes
Publikováno v:
Cell Reports
Cell Reports, Vol 13, Iss 1, Pp 108-121 (2015)
Cell Reports, Vol 13, Iss 1, Pp 108-121 (2015)
Summary Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER binding regi
Autor:
Frances V. Fuller-Pace, Manikandan Periyasamy, David W. Meek, Hetal Patel, Holly B. Kramer, Stephan M. Feller, Laki Buluwela, Chun-Fui Lai, Meng-Lay Lin, Simak Ali
Publikováno v:
Nucleic Acids Research
Liver receptor homologue 1 (LRH-1) is an orphan nuclear receptor that has been implicated in the progression of breast, pancreatic and colorectal cancer (CRC). To determine mechanisms underlying growth promotion by LRH-1 in CRC, we undertook global e
Autor:
Frances V. Fuller-Pace, Stéphane Thiry, Michel Siegmann, Herbert Angliker, Hans Stahl, Jean Pierre Jost, Steffen Schwarz, Daniel Hess
We have shown previously that DNA demethylation by chick embryo 5-methylcytosine (5-MeC)-DNA glycosylase needs both protein and RNA. Amino acid sequences of nine peptides derived from a highly purified 5-MeC-DNA glycosylase complex were identified by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403d4c357fd8e6868fba670f0611ced2
http://doc.rero.ch/record/291554/files/27-16-3245.pdf
http://doc.rero.ch/record/291554/files/27-16-3245.pdf
Autor:
Zhao Huang, Frances V. Fuller-Pace, Yuquan Wei, Jie Zhang, Lugang Huang, Chunfen Mo, Ping Lin, Yanyan Li, Di Gong, Yuan Li, Kai Li, Yan Chen
Publikováno v:
Cancer letters. 400
Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective for non-small cell lung cancer (NSCLC) patients with EGFR mutations, almost all these patients will eventually develop acquired resistance to EGFR-TKI. How
Autor:
Frances V. Fuller-Pace
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1829:756-763
Members of the DEAD box family of RNA helicases, which are characterised by the presence of twelve conserved motifs (including the signature D-E-A-D motif) within a structurally conserved 'helicase' core, are involved in all aspects of RNA metabolism
Autor:
Frances V. Fuller-Pace, Patrick Linder
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Biochimica et Biophysica Acta, Vol. 1829, No 8 (2013) pp. 750-5
Biochimica et Biophysica Acta, Vol. 1829, No 8 (2013) pp. 750-5
DEAD-box proteins represent the largest family of RNA helicases, present in all three kingdoms of life. They are involved in a variety of processes involving RNA metabolism and in some instances also in processes that use guide RNAs. Since their firs