Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Frances Searle"'
Autor:
Frances Searle, Pat J. Browne, Tariq Hussain Khan, Ebun A. Eno-Amooquaye, Helen M. I. Osborn, Philip J. Burke
Publikováno v:
Journal of Medicinal Chemistry. 42:951-956
The design and synthesis of potent thiocarbamate inhibitors for carboxypeptidase G2 are described. The best thiocarbamate inhibitor N-(p-methoxybenzenethiocarbonyl)amino-L-glutamic acid 6d, chosen for preliminary investigations of in vitro antibody-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a896bdfd87cb31d36da344d3c0fd85
https://doi.org/10.1021/jm990004i
https://doi.org/10.1021/jm990004i
Autor:
Roger G. Melton, P Antoniw, Caroline Joy Springer, P. J. Burke, Frances Searle, G.T. Rogers, Roger F. Sherwood, Kenneth D. Bagshawe, Surinder K. Sharma, Joan A. Boden
Publikováno v:
European Journal of Cancer and Clinical Oncology. 27:1361-1366
Three novel prodrugs have been designed for use as anticancer agents. Each is a bifunctional alkylating agent which has been protected to form a relatively inactive prodrug. They are designed to be activated to their corresponding alkylating agents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5aff3eb28933db804c83231320ee53b
https://doi.org/10.1016/0277-5379(91)90010-b
https://doi.org/10.1016/0277-5379(91)90010-b
Autor:
Roger F. Sherwood, Kd Bagshawe, Roger G. Melton, P Antoniw, P. J. Burke, Caroline Joy Springer, Frances Searle, G.T. Rogers
Publikováno v:
British Journal of Cancer
A novel therapy for improving selectivity in cancer chemotherapy aims to modify distribution of a cytotoxic drug by generating it selectively at tumour sites. In this approach an antibody-enzyme conjugate is allowed to localise at the tumour sites be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5a5dfd36faeff6065e0451ae0c3779
https://doi.org/10.1038/bjc.1990.407
https://doi.org/10.1038/bjc.1990.407
Autor:
Roger G. Melton, B. Mellor, Frances Searle, Roger F. Sherwood, RB Pedley, T. Bradshaw, Kd Bagshawe
Publikováno v:
Biochemical Pharmacology. 39:1787-1791
MAWI colonic cancer cells respond to sequential treatment in vitro with carboxypeptidase G2 and trimetrexate by a delay in cell growth as measured by cell numbers, but an increase in incorporation of 75-Se-selenomethionine per cell. The cells are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5daf35e08648623d1ccd76c14d455f
https://doi.org/10.1016/0006-2952(90)90126-6
https://doi.org/10.1016/0006-2952(90)90126-6
Publikováno v:
British Journal of Cancer
The in vivo localising and clearance properties of conjugates of the folate-degrading enzyme carboxypeptidase G2 (CPG2) with anti-human chorionic gonadotrophin (W14A) were measured in nude mice bearing CC3 choriocarcinoma xenografts. Conjugates of W1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb54cf5bc5f26a0c24ce88ec44e1037f
https://doi.org/10.1038/bjc.1990.92
https://doi.org/10.1038/bjc.1990.92
Autor:
J. Humm, RB Pedley, Frances Searle, Joan A. Boden, Kd Bagshawe, P. J. Southall, GM Boxer, R. H. J. Begent
Publikováno v:
British Journal of Cancer
Autoradiography with 125I-labelled antibodies 17-1-A and 11-285-14 (anti-carcinoembryonic antigen) injected singly or together into nude mice carrying two distinct human colorectal cancer xenografts delineates marked changes in distribution and reten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c78fb9cf281a9e7b1360567662f7ca4
https://doi.org/10.1038/bjc.1990.40
https://doi.org/10.1038/bjc.1990.40
Publikováno v:
British Journal of Cancer
Polyethylene glycol modification of the antibody--enzyme conjugate, F(ab')2-A5B7-CPG2, extends its duration in the circulation of nude mice bearing human colonic cancer xenografts (LS174T). Increased concentration of modified conjugate is achieved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773860d5de1ab5e91889b274213cb214
https://pubmed.ncbi.nlm.nih.gov/8645574
https://pubmed.ncbi.nlm.nih.gov/8645574
Autor:
T. Adam, Frances Searle, P Southall, S.M. Chantler, A.B. Goodall, Kd Bagshawe, G.M. Boxer, H. D. C. Mitchell
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 186(3)
Ca antigen levels in serum samples from three groups of patients were assayed. From a survey of 173 patients with various malignancies, elevated levels were found most consistently in patients with metastatic breast cancer. Spearman rank correlation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f64b8494a1584845c495e8e1bfead3c
https://pubmed.ncbi.nlm.nih.gov/2311260
https://pubmed.ncbi.nlm.nih.gov/2311260
Autor:
G. J. S. Rustin, Frances Searle, P. A. Philip, R. H. J. Begent, T. Adam, AJ Green, Kd Bagshawe, E. S. Newlands
Publikováno v:
British Journal of Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf89a48cb10137db440170fd2294ead
https://doi.org/10.1038/bjc.1991.27
https://doi.org/10.1038/bjc.1991.27
Publikováno v:
Journal of the Royal Society of Medicine. 73:624-630
131Iodine (131I) labelled antibody directed against human chorionic gonadatrophin (hCG) was given on 21 occasions to 18 patients with hCG-producing neoplasms. Tumours were localized by external scintigraphy in 13 of 21 investigations. Positive result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a56a13a3b60756ee775627dbdae0011
https://doi.org/10.1177/014107688007300905
https://doi.org/10.1177/014107688007300905