Zobrazeno 1 - 10
of 386
pro vyhledávání: '"Frances R. Balkwill"'
Autor:
Francesca R. Delvecchio, Rachel E.A. Fincham, Sarah Spear, Andrew Clear, Marina Roy-Luzarraga, Frances R. Balkwill, John G. Gribben, Michele Bombardieri, Kairbaan Hodivala-Dilke, Melania Capasso, Hemant M. Kocher
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1543-1565 (2021)
Background and aims: The presence of tertiary lymphoid structures (TLSs) may confer survival benefit to patients with pancreatic ductal adenocarcinoma (PDAC), in an otherwise immunologically inert malignancy. Yet, the precise role in PDAC has not bee
Externí odkaz:
https://doaj.org/article/b635dee8c698441ab3175efcb13b1c08
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101086- (2022)
Summary: Three-dimensional (3D), multicellular in vitro models provide a useful platform for studying human cancer biology, particularly through deconvolution of the tumor microenvironment, or where animal models do not recapitulate the human conditi
Externí odkaz:
https://doaj.org/article/bab39619a3de40b4837c4561809b9b47
Autor:
Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana S. H. Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E. Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie Baker, Marina Roy-Luzarraga, Trevor A. Graham, Julie Foster, Yu Wang, James J. Campbell, Rajinder Singh, Penglie Zhang, Thomas J. Schall, Frances R. Balkwill, Jane Sosabowski, Pedro R. Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast an
Externí odkaz:
https://doaj.org/article/514da35f7c834a7f879f285d226a9e53
Autor:
Robin M. Delaine-Smith, Eleni Maniati, Beatrice Malacrida, Sam Nichols, Reza Roozitalab, Roanne R. Jones, Laura S.M. Lecker, Oliver M.T. Pearce, Martin M. Knight, Frances R. Balkwill
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102674- (2021)
Summary: In a multi-level “deconstruction” of omental metastases, we previously identified a prognostic matrisome gene expression signature in high-grade serous ovarian cancer (HGSOC) and twelve other malignancies. Here, our aim was to understand
Externí odkaz:
https://doaj.org/article/6068ad32821044adbec1edf7e797e977
Autor:
Beatrice Malacrida, Sam Nichols, Eleni Maniati, Roanne Jones, Robin Delanie-Smith, Reza Roozitalab, Eleanor J. Tyler, Morgan Thomas, Gina Boot, Jonas Mackerodt, Michelle Lockley, Martin M. Knight, Frances R. Balkwill, Oliver M.T. Pearce
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102676- (2021)
Summary: Guided by a multi-level “deconstruction” of omental metastases, we developed a tetra (four cell)-culture model of primary human mesothelial cells, fibroblasts, adipocytes, and high-grade serous ovarian cancer (HGSOC) cell lines. This mul
Externí odkaz:
https://doaj.org/article/99a346004e8b4e63bd0a6643a5d15ba8
Autor:
Eleni Maniati, Chiara Berlato, Ganga Gopinathan, Owen Heath, Panoraia Kotantaki, Anissa Lakhani, Jacqueline McDermott, Colin Pegrum, Robin M. Delaine-Smith, Oliver M.T. Pearce, Priyanka Hirani, Joash D. Joy, Ludmila Szabova, Ruth Perets, Owen J. Sansom, Ronny Drapkin, Peter Bailey, Frances R. Balkwill
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 525-540.e7 (2020)
Summary: Although there are many prospective targets in the tumor microenvironment (TME) of high-grade serous ovarian cancer (HGSOC), pre-clinical testing is challenging, especially as there is limited information on the murine TME. Here, we characte
Externí odkaz:
https://doaj.org/article/4fb7e3ead62545e4b6563c1065542a49
Autor:
Juliana B. Candido, Jennifer P. Morton, Peter Bailey, Andrew D. Campbell, Saadia A. Karim, Thomas Jamieson, Laura Lapienyte, Aarthi Gopinathan, William Clark, Ewan J. McGhee, Jun Wang, Monica Escorcio-Correia, Raphael Zollinger, Rozita Roshani, Lisa Drew, Loveena Rishi, Rebecca Arkell, T.R. Jeffry Evans, Colin Nixon, Duncan I. Jodrell, Robert W. Wilkinson, Andrew V. Biankin, Simon T. Barry, Frances R. Balkwill, Owen J. Sansom
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1448-1460 (2018)
Summary: Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapies including single-agent immunotherapy and has a dense desmoplastic stroma, and most patients present with advanced metastatic disease. We reveal that macrophages are the d
Externí odkaz:
https://doaj.org/article/45c8c19d20b94803a6045e1c8286f6ed
Autor:
Sarah Spear, Juliana B. Candido, Jacqueline R. McDermott, Cristina Ghirelli, Eleni Maniati, Stephen A. Beers, Frances R. Balkwill, Hemant M. Kocher, Melania Capasso
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
B cells are salient features of pancreatic ductal adenocarcinoma (PDAC) tumors, yet their role in this disease remains controversial. Murine studies have indicated a protumoral role for B cells, whereas clinical data show tumor-infiltrating B cells a
Externí odkaz:
https://doaj.org/article/887b3c9ae24445558ccc4bfff2414f40
Autor:
Joseph Kwong, Franky Leung Chan, Kwong-kwok Wong, Michael J. Birrer, Kyra M. Archibald, Frances R. Balkwill, Ross S. Berkowitz, Samuel C. Mok
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 6, Pp 529-541 (2009)
In this study, we established an in vitro organoid model of normal human ovarian surface epithelial (HOSE) cells. The spheroids of these normal HOSE cells resembled epithelial inclusion cysts in human ovarian cortex, which are the cells of origin of
Externí odkaz:
https://doaj.org/article/8addf93193c04e92a9cc0a6746c97837
Autor:
Irene Olivera, Rebeca Sanz-Pamplona, Elixabet Bolaños, Inmaculada Rodriguez, Iñaki Etxeberria, Assunta Cirella, Josune Egea, Saray Garasa, Itziar Migueliz, Iñaki Eguren-Santamaria, Miguel F. Sanmamed, Javier Glez-Vaz, Arantza Azpilikueta, Maite Alvarez, María C. Ochoa, Beatrice Malacrida, David Propper, Carlos E. de Andrea, Pedro Berraondo, Frances R. Balkwill, Álvaro Teijeira, Ignacio Melero
Publikováno v:
Cancer Discovery. 12:2140-2157
Interleukin-8 (CXCL8) produced in the tumor microenvironment correlates with poor response to checkpoint inhibitors and is known to chemoattract and activate immunosuppressive myeloid leukocytes. In human cancer, IL8 mRNA levels correlate with IL1B a