Výsledky vyhledávání - "Frances R Balkwill"

Akademický článek

Airway dendritic cell maturation in children exposed to air pollution.

Autor: Abigail L Whitehouse, Naseem Mushtaq, Lisa Miyashita, Benjamin Barratt, Ameerah Khan, Harpal Kalsi, Lee Koh, Michele G Padovan, Rossa Brugha, Frances R Balkwill, Andrew J Stagg, Jonathan Grigg

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0232040 (2020)

Urban particulate matter (PM) enhances airway dendritic cell (DC) maturation in vitro. However, to date, there are no data on the association between exposure to urban PM and DC maturation in vivo. We sought to determine whether exposure of school-ag

Externí odkaz: https://doaj.org/article/8477befe7dd64b19a3fc40868e74c9e1

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Akademický článek

Building in vitro 3D human multicellular models of high-grade serous ovarian cancer

Autor: Beatrice Malacrida, Oliver M.T. Pearce, Frances R. Balkwill

Publikováno v: STAR Protocols, Vol 3, Iss 1, Pp 101086- (2022)

Summary: Three-dimensional (3D), multicellular in vitro models provide a useful platform for studying human cancer biology, particularly through deconvolution of the tumor microenvironment, or where animal models do not recapitulate the human conditi

Externí odkaz: https://doaj.org/article/bab39619a3de40b4837c4561809b9b47

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Akademický článek

Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment

Autor: Eleni Maniati, Chiara Berlato, Ganga Gopinathan, Owen Heath, Panoraia Kotantaki, Anissa Lakhani, Jacqueline McDermott, Colin Pegrum, Robin M. Delaine-Smith, Oliver M.T. Pearce, Priyanka Hirani, Joash D. Joy, Ludmila Szabova, Ruth Perets, Owen J. Sansom, Ronny Drapkin, Peter Bailey, Frances R. Balkwill

Publikováno v: Cell Reports, Vol 30, Iss 2, Pp 525-540.e7 (2020)

Summary: Although there are many prospective targets in the tumor microenvironment (TME) of high-grade serous ovarian cancer (HGSOC), pre-clinical testing is challenging, especially as there is limited information on the murine TME. Here, we characte

Externí odkaz: https://doaj.org/article/4fb7e3ead62545e4b6563c1065542a49

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Akademický článek

CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

Publikováno v: Cell Reports, Vol 23, Iss 5, Pp 1448-1460 (2018)

Summary: Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapies including single-agent immunotherapy and has a dense desmoplastic stroma, and most patients present with advanced metastatic disease. We reveal that macrophages are the d

Externí odkaz: https://doaj.org/article/45c8c19d20b94803a6045e1c8286f6ed

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Akademický článek

Discrepancies in the Tumor Microenvironment of Spontaneous and Orthotopic Murine Models of Pancreatic Cancer Uncover a New Immunostimulatory Phenotype for B Cells

Autor: Sarah Spear, Juliana B. Candido, Jacqueline R. McDermott, Cristina Ghirelli, Eleni Maniati, Stephen A. Beers, Frances R. Balkwill, Hemant M. Kocher, Melania Capasso

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

B cells are salient features of pancreatic ductal adenocarcinoma (PDAC) tumors, yet their role in this disease remains controversial. Murine studies have indicated a protumoral role for B cells, whereas clinical data show tumor-infiltrating B cells a

Externí odkaz: https://doaj.org/article/887b3c9ae24445558ccc4bfff2414f40

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