Zobrazeno 1 - 10
of 384
pro vyhledávání: '"Frances R, Balkwill"'
Autor:
Francesca R. Delvecchio, Rachel E.A. Fincham, Sarah Spear, Andrew Clear, Marina Roy-Luzarraga, Frances R. Balkwill, John G. Gribben, Michele Bombardieri, Kairbaan Hodivala-Dilke, Melania Capasso, Hemant M. Kocher
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1543-1565 (2021)
Background and aims: The presence of tertiary lymphoid structures (TLSs) may confer survival benefit to patients with pancreatic ductal adenocarcinoma (PDAC), in an otherwise immunologically inert malignancy. Yet, the precise role in PDAC has not bee
Externí odkaz:
https://doaj.org/article/b635dee8c698441ab3175efcb13b1c08
Autor:
Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana S. H. Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E. Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie Baker, Marina Roy-Luzarraga, Trevor A. Graham, Julie Foster, Yu Wang, James J. Campbell, Rajinder Singh, Penglie Zhang, Thomas J. Schall, Frances R. Balkwill, Jane Sosabowski, Pedro R. Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast an
Externí odkaz:
https://doaj.org/article/514da35f7c834a7f879f285d226a9e53
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101086- (2022)
Summary: Three-dimensional (3D), multicellular in vitro models provide a useful platform for studying human cancer biology, particularly through deconvolution of the tumor microenvironment, or where animal models do not recapitulate the human conditi
Externí odkaz:
https://doaj.org/article/bab39619a3de40b4837c4561809b9b47
Autor:
Robin M. Delaine-Smith, Eleni Maniati, Beatrice Malacrida, Sam Nichols, Reza Roozitalab, Roanne R. Jones, Laura S.M. Lecker, Oliver M.T. Pearce, Martin M. Knight, Frances R. Balkwill
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102674- (2021)
Summary: In a multi-level “deconstruction” of omental metastases, we previously identified a prognostic matrisome gene expression signature in high-grade serous ovarian cancer (HGSOC) and twelve other malignancies. Here, our aim was to understand
Externí odkaz:
https://doaj.org/article/6068ad32821044adbec1edf7e797e977
Autor:
Beatrice Malacrida, Sam Nichols, Eleni Maniati, Roanne Jones, Robin Delanie-Smith, Reza Roozitalab, Eleanor J. Tyler, Morgan Thomas, Gina Boot, Jonas Mackerodt, Michelle Lockley, Martin M. Knight, Frances R. Balkwill, Oliver M.T. Pearce
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102676- (2021)
Summary: Guided by a multi-level “deconstruction” of omental metastases, we developed a tetra (four cell)-culture model of primary human mesothelial cells, fibroblasts, adipocytes, and high-grade serous ovarian cancer (HGSOC) cell lines. This mul
Externí odkaz:
https://doaj.org/article/99a346004e8b4e63bd0a6643a5d15ba8
Autor:
Abigail L Whitehouse, Naseem Mushtaq, Lisa Miyashita, Benjamin Barratt, Ameerah Khan, Harpal Kalsi, Lee Koh, Michele G Padovan, Rossa Brugha, Frances R Balkwill, Andrew J Stagg, Jonathan Grigg
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232040 (2020)
Urban particulate matter (PM) enhances airway dendritic cell (DC) maturation in vitro. However, to date, there are no data on the association between exposure to urban PM and DC maturation in vivo. We sought to determine whether exposure of school-ag
Externí odkaz:
https://doaj.org/article/8477befe7dd64b19a3fc40868e74c9e1
Autor:
Eleni Maniati, Chiara Berlato, Ganga Gopinathan, Owen Heath, Panoraia Kotantaki, Anissa Lakhani, Jacqueline McDermott, Colin Pegrum, Robin M. Delaine-Smith, Oliver M.T. Pearce, Priyanka Hirani, Joash D. Joy, Ludmila Szabova, Ruth Perets, Owen J. Sansom, Ronny Drapkin, Peter Bailey, Frances R. Balkwill
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 525-540.e7 (2020)
Summary: Although there are many prospective targets in the tumor microenvironment (TME) of high-grade serous ovarian cancer (HGSOC), pre-clinical testing is challenging, especially as there is limited information on the murine TME. Here, we characte
Externí odkaz:
https://doaj.org/article/4fb7e3ead62545e4b6563c1065542a49
Autor:
Juliana B. Candido, Jennifer P. Morton, Peter Bailey, Andrew D. Campbell, Saadia A. Karim, Thomas Jamieson, Laura Lapienyte, Aarthi Gopinathan, William Clark, Ewan J. McGhee, Jun Wang, Monica Escorcio-Correia, Raphael Zollinger, Rozita Roshani, Lisa Drew, Loveena Rishi, Rebecca Arkell, T.R. Jeffry Evans, Colin Nixon, Duncan I. Jodrell, Robert W. Wilkinson, Andrew V. Biankin, Simon T. Barry, Frances R. Balkwill, Owen J. Sansom
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1448-1460 (2018)
Summary: Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapies including single-agent immunotherapy and has a dense desmoplastic stroma, and most patients present with advanced metastatic disease. We reveal that macrophages are the d
Externí odkaz:
https://doaj.org/article/45c8c19d20b94803a6045e1c8286f6ed
Autor:
Sarah Spear, Juliana B. Candido, Jacqueline R. McDermott, Cristina Ghirelli, Eleni Maniati, Stephen A. Beers, Frances R. Balkwill, Hemant M. Kocher, Melania Capasso
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
B cells are salient features of pancreatic ductal adenocarcinoma (PDAC) tumors, yet their role in this disease remains controversial. Murine studies have indicated a protumoral role for B cells, whereas clinical data show tumor-infiltrating B cells a
Externí odkaz:
https://doaj.org/article/887b3c9ae24445558ccc4bfff2414f40
Autor:
Frances R. Balkwill, Eleni Maniati, Jacqueline McDermott, David D. Bowtell, Rebecca Kristeleit, Dale W. Garsed, Panoraia Kotantaki, Florian Laforets, Rowan Miller, Michael-John Devlin
Some patients with advanced clear-cell ovarian cancer (CCOC) respond to immunotherapy; however, little is known about the tumor microenvironment (TME) of this relatively rare disease. Here, we describe a comprehensive quantitative and topographical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52749b1e5bf69beb0cbaba8b638c10e4
https://doi.org/10.1158/2326-6066.c.6550844
https://doi.org/10.1158/2326-6066.c.6550844
