Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Frances Prelli"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Neurofibrillary tangles (NFTs) are a major pathologic hallmark of Alzheimer’s disease (AD). Several studies have shown that amyloid β oligomers (Aβo) and tau oligomers mediate their toxicity, in part, via binding to cellular prion protein (PrPC)
Externí odkaz:
https://doaj.org/article/e68e227d20f342b7a0d480ed225ac9e9
Autor:
Krystal Herline, Frances Prelli, Pankaj Mehta, Claire MacMurray, Fernando Goñi, Thomas Wisniewski
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-18 (2018)
Abstract Background Alzheimer’s disease (AD) is characterized by physiologically endogenous proteins amyloid beta (Aβ) and tau undergoing a conformational change and accumulating as soluble oligomers and insoluble aggregates. Tau and Aβ soluble o
Externí odkaz:
https://doaj.org/article/2b668fab6da14d7a887f0e1fb9ebb51a
Autor:
Fernando Goñi, Mitchell Martá-Ariza, Krystal Herline, Daniel Peyser, Allal Boutajangout, Pankaj Mehta, Eleanor Drummond, Frances Prelli, Thomas Wisniewski
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Background Oligomeric forms of amyloid-β (Aβ) and tau are increasing being recognized as key toxins in the pathogenesis of Alzheimer’s disease (AD). Methods We developed a novel monoclonal antibody (mAb), GW-23B7, that recognizes β-shee
Externí odkaz:
https://doaj.org/article/bcce7dc379a143f1a797a51be5c277df
Autor:
Shan Liu, Shinae Park, Grant Allington, Frances Prelli, Yanjie Sun, Mitchell Martá-Ariza, Henrieta Scholtzova, Goutam Biswas, Bernard Brown, Philip B. Verghese, Pankaj D. Mehta, Yong-Uk Kwon, Thomas Wisniewski
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer’s disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at re
Externí odkaz:
https://doaj.org/article/c20bbec876ff40f9b955ba8a66acaacb
Autor:
Martin J. Sadowski, Joanna Pankiewicz, Frances Prelli, Henrieta Scholtzova, Daryl S. Spinner, Regina B. Kascsak, Richard J. Kascsak, Thomas Wisniewski
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 2, Pp 267-278 (2009)
The pathogenesis of prion diseases is related to conformational transformation of cellular prion protein (PrPC) into a toxic, infectious, and self-replicating conformer termed PrPSc. Following extracerebral inoculation, the replication of PrPSc is co
Externí odkaz:
https://doaj.org/article/f71a4174c0504af08ee00e42e991de5b
Autor:
Erika Chung, Frances Prelli, Stephen Dealler, Woo Sirl Lee, Young-Tae Chang, Thomas Wisniewski
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24844 (2011)
Prion diseases currently have no effective therapy. These illnesses affect both animal and human populations, and are characterized by the conformational change of a normal self protein PrP(C) (C for cellular) to a pathological and infectious conform
Externí odkaz:
https://doaj.org/article/ef380268c2f94591843f944213fc2e82
Autor:
Fernando Goñi, Frances Prelli, Yong Ji, Henrieta Scholtzova, Jing Yang, Yanjie Sun, Feng-Xia Liang, Regina Kascsak, Richard Kascsak, Pankaj Mehta, Thomas Wisniewski
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13391 (2010)
Many neurodegenerative diseases are characterized by the conformational change of normal self-proteins into amyloidogenic, pathological conformers, which share structural properties such as high β-sheet content and resistance to degradation. The mos
Externí odkaz:
https://doaj.org/article/57529258aef14c2d86d9ebfc40e20fbd
Autor:
Allal Boutajangout, Wei Zhang, Wed Abdali, Justin Sung Tae Kim, Frances Prelli, Thomas Wisniewski
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af714439c70b8082ffd0858dc209b6a1
https://doi.org/10.1002/alz.054074
https://doi.org/10.1002/alz.054074
Autor:
Frances Prelli, Krystal Herline, Thomas Wisniewski, Claire MacMurray, Pankaj Mehta, Fernando Goni
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-18 (2018)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Alzheimer’s disease (AD) is characterized by physiologically endogenous proteins amyloid beta (Aβ) and tau undergoing a conformational change and accumulating as soluble oligomers and insoluble aggregates. Tau and Aβ soluble oligomers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c001284ba3a161c6093067c19ce08ec
http://link.springer.com/article/10.1186/s13195-018-0384-9
http://link.springer.com/article/10.1186/s13195-018-0384-9
Autor:
Mitchell Marta-Ariza, Pankaj Mehta, Henrieta Scholtzova, Thomas Wisniewski, Grant Allington, Shinae Park, Yong-Uk Kwon, Frances Prelli, Philip B. Verghese, Bernard Brown, Yanjie Sun, Shan Liu, Goutam Biswas
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer’s disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at residues 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5499fcc9e25c2fc40505ab56c2400409
https://doaj.org/article/c20bbec876ff40f9b955ba8a66acaacb
https://doaj.org/article/c20bbec876ff40f9b955ba8a66acaacb