Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Frances Potjewyd"'
Autor:
Shane D. Falcinelli, David M. Irlbeck, Anne-Marie Turner, Frances Potjewyd, Lindsey I. James, David M. Margolis, Nancie M. Archin, Richard M. Dunham
Publikováno v:
Journal of Virus Eradication, Vol 5, Iss , Pp 47-48 (2019)
Externí odkaz:
https://doaj.org/article/59e5cbbfe88d4a85aa2f4b38e4e1022c
Autor:
Qing Zhang, Kan Gong, Albert S. Baldwin, Xianming Tan, Chengheng Liao, Kai Hong, Johnny Castillo Cabrera, Xian Chen, Ling Xie, Laura E. Herring, Emily M. Wilkerson, Lindsey I. James, Frances Potjewyd, Xijuan Liu, Haibiao Xie, Lianxin Hu
TANK binding kinase 1 (TBK1) is an important kinase involved in the innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from patients with kidney cancer with VHL loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c9a565c848d2100f8b2b6302d6c942
https://doi.org/10.1158/2159-8290.c.6547922.v1
https://doi.org/10.1158/2159-8290.c.6547922.v1
Autor:
Qing Zhang, Kan Gong, Albert S. Baldwin, Xianming Tan, Chengheng Liao, Kai Hong, Johnny Castillo Cabrera, Xian Chen, Ling Xie, Laura E. Herring, Emily M. Wilkerson, Lindsey I. James, Frances Potjewyd, Xijuan Liu, Haibiao Xie, Lianxin Hu
Quantification of IHC staining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1d1929bd20e93aabaeb3f526e9ee61
https://doi.org/10.1158/2159-8290.22535702
https://doi.org/10.1158/2159-8290.22535702
Autor:
Qing Zhang, Kan Gong, Albert S. Baldwin, Xianming Tan, Chengheng Liao, Kai Hong, Johnny Castillo Cabrera, Xian Chen, Ling Xie, Laura E. Herring, Emily M. Wilkerson, Lindsey I. James, Frances Potjewyd, Xijuan Liu, Haibiao Xie, Lianxin Hu
Extended methods and supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d286000754d8ed5122ecb47068458961
https://doi.org/10.1158/2159-8290.22535705.v1
https://doi.org/10.1158/2159-8290.22535705.v1
Autor:
Evan Healy, Rachel McCole, Craig Monger, James Nolan, Eric Conway, Gerard Brien, Cheng Wang, Hannah K Neikes, Frances Potjewyd, Michiel Vermeulen, Aoibhinn Mooney, Richard Flavin, Elisabeth Vandenberghe, Lindsey I James, Adrian P Bracken
Publikováno v:
Blood. 140:3049-3050
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44c9651fb0db21287f8232f912995beb
https://doi.org/10.1182/blood-2022-168762
https://doi.org/10.1182/blood-2022-168762
Autor:
Evan Healy, Rachel McCole, Craig Monger, Gerald L. Brien, Cheng Wang, Hannah K. Neikes, Frances Potjewyd, Michiel Vermeulen, Lindsey Ingerman James, Adrian Bracken
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::820a2c8b149d078cb7bb017d54ba2a9a
https://doi.org/10.2139/ssrn.4089979
https://doi.org/10.2139/ssrn.4089979
Publikováno v:
ACS Chemical Biology. 15:290-295
Bivalent chemical degraders provide a catalytic route to selectively degrade disease-associated proteins. By linking target-specific ligands with E3 ubiquitin ligase recruiting ligands, these compounds facilitate targeted protein ubiquitination and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9584d91b11eadd4a3e789be74385d70
https://doi.org/10.1021/acschembio.9b00972
https://doi.org/10.1021/acschembio.9b00972
Autor:
Brittany M. Bowman, Jeffrey L. Smith, Megan J. Agajanian, Alison D. Axtman, Dhaval P. Bhatt, Kyle M. LaPak, Smaranda Solomon, Michael B. Major, Frances Potjewyd, Dennis Goldfarb
The WNT/β-catenin signaling pathway is evolutionarily conserved and controls normal embryonic development, adult tissue homeostasis and regeneration. Aberrant activation or suppression of WNT signaling contributes to cancer initiation and progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15bd8b9eb80c9f15983f687f1ef739f7
https://doi.org/10.1101/2021.11.30.470617
https://doi.org/10.1101/2021.11.30.470617
Autor:
Frances Potjewyd, Alison D. Axtman
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
The Ubiquitin Proteasome System (UPS) is responsible for the degradation of misfolded or aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process involves a cascade of ubiquitin (Ub) transfer steps from E1 to E2 to E3 lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38499bba1c330ea76d1a569a5c27461e
https://www.frontiersin.org/articles/10.3389/fncel.2021.768655/full
https://www.frontiersin.org/articles/10.3389/fncel.2021.768655/full
Autor:
Emily R. Mason, Timothy M. Willson, Michael A. Stashko, Ivie L. Conlon, Kenneth H. Pearce, Brian Hardy, Charles Travis Moerk, Shaoyou Chu, Chizuru Kinoshita, Megan D. Hopkins, Frances Potjewyd, Jessica E. Young, Timothy E. Richardson, David A. Rogers, Shiva Krishna Reddy Guduru, Joel K. Annor-Gyamfi, Dmitri Kireev, Disha Soni, Stephen V. Frye, Xiaodong Wang, Carrow I. Wells, Jeffrey Aubé, Felix Nwogbo, Kevin J. Frankowski, Alison D. Axtman
IntroductionThe portfolio of novel targets to treat Alzheimer’s disease (AD) has been enriched by the AMP-AD program.MethodsA cheminformatics-driven effort enabled identification of existing small molecule modulators for many protein targets nomina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c99e07fe7252807651f172faca5abac
https://doi.org/10.1101/2021.07.22.453404
https://doi.org/10.1101/2021.07.22.453404