Zobrazeno 1 - 10 of 112 pro vyhledávání: '"Frances M. Smith"'
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Akademický článek
Loss of filamentous actin, tight junction protein expression, and paracellular barrier integrity in frataxin-deficient human brain microvascular endothelial cells—implications for blood-brain barrier physiology in Friedreich’s ataxia
Autor: Frances M. Smith, Daniel J. Kosman
Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2024)
Introduction: Friedreich’s Ataxia (FRDA) is the most prevalent inherited ataxia. FRDA results from loss of Frataxin (FXN), an essential mitochondrial iron trafficking protein. FRDA starts with an early burst of neurodegeneration of the dorsal root
Externí odkaz: https://doaj.org/article/8e199e6a8765432d8c515d9c602cb58c
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2
Akademický článek
Molecular Defects in Friedreich’s Ataxia: Convergence of Oxidative Stress and Cytoskeletal Abnormalities
Autor: Frances M. Smith, Daniel J. Kosman
Publikováno v: Frontiers in Molecular Biosciences, Vol 7 (2020)
Friedreich’s ataxia (FRDA) is a multi-faceted disease characterized by progressive sensory–motor loss, neurodegeneration, brain iron accumulation, and eventual death by hypertrophic cardiomyopathy. FRDA follows loss of frataxin (FXN), a mitochond
Externí odkaz: https://doaj.org/article/2c214e683eb84dd48afba7a187c32286
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3
Frataxin-deficient human brain microvascular endothelial cells lose polymerized actin and are paracellularly permeable –implications for blood-brain barrier integrity in Friedreich’s Ataxia
Autor: Frances M. Smith, Daniel J Kosman
Publikováno v: bioRxiv
BackgroundFriedreich’s Ataxia (FRDA) is the most prevalent inherited ataxia; the disease results from loss of Frataxin, an essential mitochondrial iron trafficking protein. FRDA presents as neurodegeneration of the dorsal root ganglion and cerebell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfeae8b77590ec7079d7350e5ee58f5
https://doi.org/10.1101/2023.02.09.527936
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4
Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells
Autor: Brittany L. Steimle, Danielle K. Bailey, Frances M. Smith, Shaina L. Rosenblum, Daniel J. Kosman
Publikováno v: The Journal of biological chemistry. 298(8)
Manganese (II) accumulation in human brain microvascular endothelial cells is mediated by the metal-ion transporters ZRT IRT-like protein 8 (ZIP8) and ZRT IRT-like protein 14 (ZIP14). The plasma membrane occupancy of ZIP14, in particular, is increase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06e2d662775828030aedd127ac13031
https://pubmed.ncbi.nlm.nih.gov/35787370
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5
The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels
Autor: Frances M. Smith, Brittany L. Steimle, Daniel J. Kosman
Publikováno v: J Biol Chem
Manganese supports numerous neuronal functions but in excess is neurotoxic. Consequently, regulation of manganese flux at the blood–brain barrier (BBB) is critical to brain homeostasis. However, the molecular pathways supporting the transcellular t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d2c610ab05445711fa0657deff2b4b
https://doi.org/10.1074/jbc.ra119.009371
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6
Barriers to effective drug addiction treatment for women involved in street-level prostitution: a qualitative investigation
Autor: Frances M. Smith, Lisa A. Marshall
Publikováno v: Criminal Behaviour and Mental Health. 17:163-170
Objectives To examine barriers to effective drug addiction treatment for women involved in street-level prostitution. Methods A qualitative approach was selected to enable a detailed exploration, in an informal and unthreatening manner, of the barrie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84bd47446156c8ed252b794beea3669
https://doi.org/10.1002/cbm.654
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7
Relationship of family support and ethnic minority students' achievement in science and mathematics
Autor: Cheryl O. Hausafus, Frances M. Smith
Publikováno v: Science Education. 82:111-125
The academic interest and competencies in science and mathematics of children are often begun in families. This research seeks to identify those aspects of family support that have the most influence on students' learning in mathematics and science.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::674aefaed0f4b0fe6391b1ea9a228398
https://doi.org/10.1002/(sici)1098-237x(199801)82:1<111::aid-sce6>3.0.co
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8
Preprofessionals' Perceptions of Home Economics
Autor: Lisa Christine LeBleu, Frances M. Smith
Publikováno v: Home Economics Research Journal. 22:422-440
The major purpose of this study was to describe undergraduate students' experiences and perceptions of home economics and to work with students to produce a description of those experiences and their relevance to an integrative home economics perspec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f74fc57b05f00aba55b156bdfe6c7487
https://doi.org/10.1177/0046777494224004
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10
Restaurant managers' learning styles and their implications
Autor: Cathy Hui-chun Hsu, Dori A. Finley, Frances M. Smith
Publikováno v: International Journal of Hospitality Management. 10:81-93
This study identified the learning styles of unit and district level restaurant managers by using the Semantic Differential format of Kolb's Learning Style Inventory. Data were collected from 118 unit level managers and 45 district level managers. Le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a06246a04fe09bcb17b533228053b36
https://doi.org/10.1016/0278-4319(91)90009-7
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