Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Frances M. Brodsky"'
Autor:
Matteo Biancospino, Gwen R. Buel, Carlos A. Niño, Elena Maspero, Rossella Scotto di Perrotolo, Andrea Raimondi, Lisa Redlingshöfer, Janine Weber, Frances M. Brodsky, Kylie J. Walters, Simona Polo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Clathrin light chains (CLCa and CLCb) are major constituents of clathrin-coated vesicles. Here authors find and structurally characterize the selective interaction between CLCa and the actin motor protein myosin VI which act together to generate the
Externí odkaz:
https://doaj.org/article/8f91af4c82334c6394eedff499f3dee1
To identify functional differences between vertebrate clathrin light chains (CLCa or CLCb), phenotypes of mice lacking genes encoding either isoform were characterised. Mice without CLCa displayed 50% neonatal mortality, reduced body weight, reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::518ba8da5730913171b8881a1f4ef0e6
https://doi.org/10.1101/2023.04.25.538235
https://doi.org/10.1101/2023.04.25.538235
Autor:
Matteo Fumagalli, Stephane M Camus, Yoan Diekmann, Alice Burke, Marine D Camus, Paul J Norman, Agnel Joseph, Laurent Abi-Rached, Andrea Benazzo, Rita Rasteiro, Iain Mathieson, Maya Topf, Peter Parham, Mark G Thomas, Frances M Brodsky
Publikováno v:
eLife, Vol 8 (2019)
CHC22 clathrin plays a key role in intracellular membrane traffic of the insulin-responsive glucose transporter GLUT4 in humans. We performed population genetic and phylogenetic analyses of the CHC22-encoding CLTCL1 gene, revealing independent gene l
Externí odkaz:
https://doaj.org/article/788427027f4d4457b906ca8b15739a62
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c386f70f2b02e5a609e67f92edc1253
https://doi.org/10.1016/b978-0-12-821618-7.00155-3
https://doi.org/10.1016/b978-0-12-821618-7.00155-3
Autor:
Joshua Greig, George T. Bates, Daowen I. Yin, Boris Simonetti, Peter J. Cullen, Frances M. Brodsky
The two clathrin isoforms, CHC17 and CHC22, generate separate vesicles for intracellular transport. CHC17 mediates endocytosis and housekeeping membrane traffic in all cells. CHC22, expressed most highly in skeletal muscle, transports the glucose tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51f553da0204fa1dc0abf7bb2a01a1e8
https://doi.org/10.1101/2022.12.21.520923
https://doi.org/10.1101/2022.12.21.520923
Autor:
Sarah M. Smith, Gabrielle Laroque, Katherine M. Wood, Kyle L. Morris, Alan M. Roseman, Richard B. Sessions, Stephen J. Royle, Corinne J. Smith, Frances M. Brodsky
Publikováno v:
Biophysical Journal. 122:514a
Autor:
Xiaowen Duan, Dougall M. Norris, Sean J. Humphrey, Pengyi Yang, Kristen C. Cooke, Will P. Bultitude, Benjamin L. Parker, Olivia J. Conway, James G. Burchfield, James R. Krycer, Frances M. Brodsky, David E. James, Daniel J. Fazakerley
Publikováno v:
The Biochemical journal. 479(11)
Trafficking regulator of GLUT4-1, TRARG1, positively regulates insulin-stimulated GLUT4 trafficking and insulin sensitivity. However, the mechanism(s) by which this occurs remain(s) unclear. Using biochemical and mass spectrometry analyses we found t
Autor:
Philip N. Dannhauser, Lisa Redlingshöfer, Marine D. Camus, Ernest Palomer, Frances M. Brodsky, Patricia C. Salinas, Faye McLeod, Kit Briant, Jemima J. Burden, Yu Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This study reveals that diversity of clathrin light chain (CLC) subunits alters clathrin properties and demonstrates that the two neuronal CLC subunits work together for optimal clathrin function in synaptic vesicle formation. Our findin
Publikováno v:
Trends in Cell Biology. 30:705-719
Insulin stimulates glucose transport by triggering regulated delivery of intracellular vesicles containing the GLUT4 glucose transporter to the plasma membrane. This process is defective in diseases such as type 2 diabetes (T2DM). While studies in ro
Publikováno v:
Current Opinion in Cell Biology. 65:141-149
Understanding of the range and mechanisms of clathrin functions has developed exponentially since clathrin's discovery in 1975. Here, newly established molecular mechanisms that regulate clathrin activity and connect clathrin pathways to differentiat