Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Frances M. Anastassacos"'
Autor:
Bryan B. Hsu, Isaac N. Plant, Lorena Lyon, Frances M. Anastassacos, Jeffrey C. Way, Pamela A. Silver
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
It is difficult to precisely target bacterial populations in the mammalian gut. Here the authors use encapsulated phages to deliver dCas9 to E. coli in the mouse gut to modulate RFP expression.
Externí odkaz:
https://doaj.org/article/792e81c6c1904cf7ba9b6609a0a6e187
Autor:
Nandhini Ponnuswamy, Maartje M. C. Bastings, Bhavik Nathwani, Ju Hee Ryu, Leo Y. T. Chou, Mathias Vinther, Weiwei Aileen Li, Frances M. Anastassacos, David J. Mooney, William M. Shih
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents inin vivoapplications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharm
Externí odkaz:
https://doaj.org/article/50a682a815284a8485d185a430fa9b97
Autor:
Pamela A. Silver, Frances M. Anastassacos, Lorena Lyon, Isaac N. Plant, Jeffrey C. Way, Bryan B. Hsu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Abundant links between the gut microbiota and human health indicate that modification of bacterial function could be a powerful therapeutic strategy. The inaccessibility of the gut and inter-connections between gut bacteria and the host make it diffi
Publikováno v:
Journal of the American Chemical Society. 142(7)
DNA nanostructures (DNs) have garnered a large amount of interest as a potential therapeutic modality. However, DNs are prone to nuclease-mediated degradation and are unstable in low Mg2+ conditions; this greatly limits their utility in physiological
Autor:
Bhavik Nathwani, Mathias Vinther, Ju Hee Ryu, William M. Shih, Maartje M. C. Bastings, Weiwei Aileen Li, Nandhini Ponnuswamy, Leo Y. T. Chou, David J. Mooney, Frances M. Anastassacos
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Ponnuswamy, N, Bastings, M M C, Nathwani, B, Ryu, J H, Chou, L Y T, Vinther, M, Li, W A, Anastassacos, F M, Mooney, D J & Shih, W M 2017, ' Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation ', Nature Communications, vol. 8, 15654 . https://doi.org/10.1038/ncomms15654
Nature Communications
Ponnuswamy, N, Bastings, M M C, Nathwani, B, Ryu, J H, Chou, L Y T, Vinther, M, Li, W A, Anastassacos, F M, Mooney, D J & Shih, W M 2017, ' Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation ', Nature Communications, vol. 8, 15654 . https://doi.org/10.1038/ncomms15654
Nature Communications
DNA nanostructures have evoked great interest as potential therapeutics and diagnostics due to ease and robustness of programming their shapes, site-specific functionalizations and responsive behaviours. However, their utility in biological fluids ca
Autor:
Franziska G Leifer, William M. Shih, Donald E. Ingber, Ju Hee Ryu, Nandhini Ponnuswamy, Chenxiang Lin, Maartje M. C. Bastings, Frances M. Anastassacos, Garry Cuneo
Publikováno v:
Nano letters. 18(6)
Designer nanoparticles with controlled shapes and sizes are increasingly popular vehicles for therapeutic delivery due to their enhanced cell-delivery performance. However, our ability to fashion nanoparticles has offered only limited control over th