Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Frances M, Sladek"'
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/d5776b3290aa43cea8b49962e533af5a
Autor:
Jose Martinez-Lomeli, Poonamjot Deol, Jonathan R. Deans, Tao Jiang, Paul Ruegger, James Borneman, Frances M. Sladek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract High fat diets (HFDs) have been linked to several diseases including obesity, diabetes, fatty liver, inflammatory bowel disease (IBD) and colon cancer. In this study, we examined the impact on intestinal gene expression of three isocaloric H
Externí odkaz:
https://doaj.org/article/c072f45da8ed45e7b634c083382723e6
HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver
Autor:
Jonathan R. Deans, Poonamjot Deol, Nina Titova, Sarah H. Radi, Linh M. Vuong, Jane R. Evans, Songqin Pan, Johannes Fahrmann, Jun Yang, Bruce D. Hammock, Oliver Fiehn, Baharan Fekry, Kristin Eckel-Mahan, Frances M. Sladek
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2) which drive the expression of different isoforms. P1-HNF4α is the major isoform in the adult liver while P2-HNF4α is
Externí odkaz:
https://doaj.org/article/e1a980aa2c3548fca155dbc6f3c46efe
Autor:
Poonamjot Deol, Paul Ruegger, Geoffrey D. Logan, Ali Shawki, Jiang Li, Jonathan D. Mitchell, Jacqueline Yu, Varadh Piamthai, Sarah H. Radi, Sana Hasnain, Kamil Borkowski, John W. Newman, Declan F. McCole, Meera G. Nair, Ansel Hsiao, James Borneman, Frances M. Sladek
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTInflammatory bowel disease (IBD) is a multifactorial disease with increasing incidence in the U.S. suggesting that environmental factors, including diet, are involved. It has been suggested that excessive consumption of linoleic acid (LA, C18
Externí odkaz:
https://doaj.org/article/5cd2f4244d6b4c3b8efb161aa4fbaa8c
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte nuclear factor 4-alpha (HNF4α) drives a complex array of transcriptional programs across multiple organs. Beyond its previously documented function in the liver, HNF4α has crucial roles in the kidney, intestine, and pancreas. In the inte
Externí odkaz:
https://doaj.org/article/434b08188b394b8eacde64dfceefd807
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
In the more than 30 years since the purification and cloning of Hepatocyte Nuclear Factor 4 (HNF4α), considerable insight into its role in liver function has been gleaned from its target genes and mouse experiments. HNF4α plays a key role in lipid
Externí odkaz:
https://doaj.org/article/4e1e00eac8fe4d23a54996d9dabee216
Autor:
Baharan Fekry, Aleix Ribas-Latre, Corrine Baumgartner, Jonathan R. Deans, Christopher Kwok, Pooja Patel, Loning Fu, Rebecca Berdeaux, Kai Sun, Mikhail G. Kolonin, Sidney H. Wang, Seung-Hee Yoo, Frances M. Sladek, Kristin Eckel-Mahan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhi
Externí odkaz:
https://doaj.org/article/056eef75c52b4174ad77b500303fd84c
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Dimethylsulfoxide (DMSO) is widely used as a solvent and cryopreservative in laboratories and considered to have many beneficial health effects in humans. Oxylipins are a class of biologically active metabolites of polyunsaturated fatty acids (PUFAs)
Externí odkaz:
https://doaj.org/article/026a80fffce04244905c9ddbeb290c12
Autor:
Frances M. Sladek
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The nomenclature of hepatocyte nuclear factor-4 receptors is agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [9, 3]. While linoleic acid has been identified as the endogenous ligand for HNF4α its function remains ambiguous [75]. HN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed045cb8a538acee94bea66bc4545b0b
https://doi.org/10.2218/gtopdb/f91/2023.1
https://doi.org/10.2218/gtopdb/f91/2023.1
Autor:
Michael Allevato, Eugene Bolotin, Mark Grossman, Daniel Mane-Padros, Frances M Sladek, Ernest Martinez
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180147 (2017)
The MYC oncoprotein regulates transcription of a large fraction of the genome as an obligatory heterodimer with the transcription factor MAX. The MYC:MAX heterodimer and MAX:MAX homodimer (hereafter MYC/MAX) bind Enhancer box (E-box) DNA elements (CA
Externí odkaz:
https://doaj.org/article/34105823bffa406698793f1121860688