Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Frances L. Johnson"'
Autor:
Mengshi Li, Nicholas J. Baumhover, Dijie Liu, Brianna S. Cagle, Frédéric Boschetti, Guillaume Paulin, Dongyoul Lee, Zhiming Dai, Ephraim R. Obot, Brenna M. Marks, Ibrahim Okeil, Edwin A. Sagastume, Moustafa Gabr, F. Christopher Pigge, Frances L. Johnson, Michael K. Schultz
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 414 (2023)
203Pb and 212Pb have emerged as promising theranostic isotopes for image-guided α-particle radionuclide therapy for cancers. Here, we report a cyclen-based Pb specific chelator (PSC) that is conjugated to tyr3-octreotide via a PEG2 linker (PSC-PEG-T
Externí odkaz:
https://doaj.org/article/eb3eea60c8ed4baa93aaaa7ffc84798d
Autor:
Kelly D. Orcutt, Kelly E. Henry, Christine Habjan, Keryn Palmer, Jack Heimann, Julie M. Cupido, Vijay Gottumukkala, Derek D. Cissell, Morgan C. Lyon, Amira I. Hussein, Dijie Liu, Mengshi Li, Frances L. Johnson, Michael K. Schultz
Publikováno v:
Molecules, Vol 27, Iss 18, p 5831 (2022)
[212Pb]VMT01 is a melanocortin 1 receptor (MC1R) targeted theranostic ligand in clinical development for alpha particle therapy for melanoma. 212Pb has an elementally matched gamma-emitting isotope 203Pb; thus, [203Pb]VMT01 can be used as an imaging
Externí odkaz:
https://doaj.org/article/1f754217da644730acfef98077e3421e
Autor:
Mengshi Li, Dijie Liu, Dongyoul Lee, Yinwen Cheng, Nicholas J. Baumhover, Brenna M. Marks, Edwin A. Sagastume, Zuhair K. Ballas, Frances L. Johnson, Zachary S. Morris, Michael K. Schultz
Publikováno v:
Cancers, Vol 13, Iss 15, p 3676 (2021)
Radiotherapy can facilitate the immune recognition of immunologically “cold” tumors and enhance the efficacy of anti-PD-1 and anti-CTLA-4 immune checkpoint inhibitors (ICIs) in melanoma. Systemic administration of receptor-targeted radionuclide t
Externí odkaz:
https://doaj.org/article/cff49d53286f4b609a74d8b165baad6e
Autor:
Michael K. Schultz, Dijie Liu, Mengshi Li, Brianna S. Cagle, Zhiming Dai, Dongyoul Lee, Kelly Orcutt, Edwin Sagastume, Nicholas J. Baumhover, Ivy Vance, Amos Hedt, Yusuf Menda, Frances L. Johnson
Publikováno v:
Endocrine Abstracts.
Autor:
Kelly D, Orcutt, Kelly E, Henry, Christine, Habjan, Keryn, Palmer, Jack, Heimann, Julie M, Cupido, Vijay, Gottumukkala, Derek D, Cissell, Morgan C, Lyon, Amira I, Hussein, Dijie, Liu, Mengshi, Li, Frances L, Johnson, Michael K, Schultz
Publikováno v:
Molecules (Basel, Switzerland). 27(18)
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Autor:
Brenna M. Marks, Matthew Block, Geoffrey B. Johnson, Carrie B. Hruska, Mukesh K. Pandey, Andrew Paulsen, Michael K. Schultz, Michael A. McDonald, Edwin A. Sagastume, Frances L. Johnson
Publikováno v:
Cancer Research. 83:CT104-CT104
Purpose: Melanocortin 1 receptor (MC1R) has been shown in animal models to be a target for effective radionuclide therapy. This first-in-human clinical trial studied the safety and biodistribution of two novel MC1R-targeted imaging tracers designed t
Autor:
Brian E. Zimmerman, Michael K. Schultz, Mengshi Li, Keith R Olewine, Daniel R. McAlister, Anthony J DeGraffenreid, Dongyoul Lee, Roy Copping, Stephen A. Graves, Edwin A Sagastume, Frances L. Johnson, Roy H Larsen, Saed Mirzadeh
Publikováno v:
Current Medicinal Chemistry. 27:7003-7031
Receptor-targeted image-guided Radionuclide Therapy (TRT) is increasingly recognized as a promising approach to cancer treatment. In particular, the potential for clinical translation of receptor-targeted alpha-particle therapy is receiving considera
Autor:
Dongyoul Lee, Frances L. Johnson, Brenna Marks, Yinwen Cheng, Zachary S. Morris, Michael K. Schultz, Dijie Liu, Zuhair K. Ballas, Edwin A Sagastume, Nicholas J. Baumhover, Mengshi Li
Publikováno v:
Cancers
Volume 13
Issue 15
Cancers, Vol 13, Iss 3676, p 3676 (2021)
Volume 13
Issue 15
Cancers, Vol 13, Iss 3676, p 3676 (2021)
Simple Summary Radiation therapy and immune checkpoint inhibitors (ICIs) have been demonstrated to cooperatively activate adaptive anti-tumor immunity with curative potential in preclinical models of melanoma. Receptor-targeted radionuclide therapy c
Autor:
Frances L. Johnson, Somya Kapoor, Sarah L. Mott, Edwin A Sagastume, Dongyoul Lee, Michael R. Acevedo, Michael K. Schultz, Susan A. Walsh, Dijie Liu, Katherine N. Gibson-Corley, Thomas P. Quinn, Mengshi Li
Publikováno v:
Mol Pharm
Melanocortin 1 receptor (MC1R) is under investigation as a target for drug delivery for metastatic melanoma therapy and imaging. The purpose of this study was to determine the potential of using BRAF inhibitors (BRAF(i)) and histone deacetylase inhib
Autor:
Kyle Jenn, Michael C. Giudici, Frances L. Johnson, Rizwan Tahir, Rudhir Tandon, Vlad Cotarlan, Carol Johnson, Yassar Nabeel, KellyAnn Light-McGroary, Uzodinma Emerenini, Jennifer Franzwa, Chakradhari Inampudi, Jennifer Goerbig-Campbell
Publikováno v:
The American Journal of Cardiology. 123:93-99
The benefit of cardiac resynchronization therapy in patients supported by a left ventricular assist device (LVAD) is unknown. There are currently no guidelines regarding the continuation, discontinuation or pacemaker (PM) settings post-LVAD implant.