Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Frances L Byrne"'
Autor:
Hudson W Coates, Isabelle M Capell-Hattam, Ellen M Olzomer, Ximing Du, Rhonda Farrell, Hongyuan Yang, Frances L Byrne, Andrew J Brown
Publikováno v:
eLife, Vol 12 (2023)
Cholesterol synthesis is both energy- and oxygen-intensive, yet relatively little is known of the regulatory effects of hypoxia on pathway enzymes. We previously showed that the rate-limiting and first oxygen-dependent enzyme of the committed cholest
Externí odkaz:
https://doaj.org/article/3f53fc512fcc4b44b302c034457a3da2
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21717 (2011)
Epothilones are a new class of microtubule stabilizing agents with promising preclinical and clinical activity. Their cellular target is β-tubulin and factors influencing intrinsic sensitivity to epothilones are not well understood. In this study, t
Externí odkaz:
https://doaj.org/article/f37e4dc8e92540b894de59f20af6d5d8
Autor:
Sing-Young Chen, Ellen M. Olzomer, Martina Beretta, James Cantley, Craig S. Nunemaker, Kyle L. Hoehn, Frances L. Byrne
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9798 (2022)
Obesity-related insulin resistance is a highly prevalent and growing health concern, which places stress on the pancreatic islets of Langerhans by increasing insulin secretion to lower blood glucose levels. The glucose transporters GLUT1 and GLUT3 pl
Externí odkaz:
https://doaj.org/article/11e2c49c4e454001b9ee519897b80eb4
Autor:
Yuantao Huo, Laura K. Buckton, Jack L. Bennett, Eloise C. Smith, Frances L. Byrne, Kyle L. Hoehn, Marwa N. Rahimi, Shelli R. McAlpine
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 728-739 (2019)
The most challenging issue facing peptide drug development is producing a molecule with optimal physical properties while maintaining target binding affinity. Masking peptides with protecting groups that can be removed inside the cell, produces a cel
Externí odkaz:
https://doaj.org/article/6788bb62f2ca40478336fde2257a8a2c
Autor:
Nadeem O. Kaakoush, Ellen M. Olzomer, Melidya Kosasih, Amy R. Martin, Farokh Fargah, Neil Lambie, Daniella Susic, Kyle L. Hoehn, Rhonda Farrell, Frances L. Byrne
Publikováno v:
Cancers, Vol 14, Iss 9, p 2141 (2022)
Obesity is a risk factor for endometrial cancer. The aim of this study was to determine whether actively replicating microbiota in the endometrium differ between obese vs. lean and cancer vs. benign states. We performed 16S rRNA amplicon sequencing o
Externí odkaz:
https://doaj.org/article/b1247d62b8104fba8f3db6ad74ee0e82
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4477 (2022)
Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer. Low numbers of HCC patients being suitable for liver resection or transplantation and multidrug resistance development during pharmacotherapy leads to high death rates
Externí odkaz:
https://doaj.org/article/aac2009c15d148f3bb85530222daa7b3
Autor:
Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. Santos, Kate GR. Quinlan, Nigel Turner, Daniel J. Fazakerley, Naresh Kumar, Kyle L. Hoehn
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
A hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical library screening approach to identify molecules that
Externí odkaz:
https://doaj.org/article/5e4c5baf666144d5a43fe60f14c4e6fb
Autor:
Maria Kavallaris, Frances L. Byrne, Michael S. Shum, Melissa H. Chang, Amelia L. Parker, Lu Yang, Mia C. Akerfeldt, Sharon S. Sagnella, Tanya Dwarte, Marjorie Liu, Rafael B. Erlich, Pei Pei Gan, Joshua A. McCarroll
A) A graph showing a decrease in βIII-tubulin mRNA expression in A549 NSCLC cells stably expressing βIII-tubulin shRNA (pRS/βIIISH61) vs. cells stably expressing control shRNA (pRS/CtrlSH27). B) Representative western blot demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5ccfe0d79bccd93ef2eb198a0a373d
https://doi.org/10.1158/0008-5472.22404861
https://doi.org/10.1158/0008-5472.22404861
Autor:
Maria Kavallaris, Frances L. Byrne, Michael S. Shum, Melissa H. Chang, Amelia L. Parker, Lu Yang, Mia C. Akerfeldt, Sharon S. Sagnella, Tanya Dwarte, Marjorie Liu, Rafael B. Erlich, Pei Pei Gan, Joshua A. McCarroll
βIII-tubulin shRNA NSCLC cells show increased maspin expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca665d185d7b66616d18093ad4536678
https://doi.org/10.1158/0008-5472.22404867
https://doi.org/10.1158/0008-5472.22404867
Autor:
Maria Kavallaris, Frances L. Byrne, Michael S. Shum, Melissa H. Chang, Amelia L. Parker, Lu Yang, Mia C. Akerfeldt, Sharon S. Sagnella, Tanya Dwarte, Marjorie Liu, Rafael B. Erlich, Pei Pei Gan, Joshua A. McCarroll
Validation of proteins found to be differentially expressed in H460 βIII-tubulin shRNA expressing cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7802fc5f060c43152e47f5e073f1a07
https://doi.org/10.1158/0008-5472.22404870.v1
https://doi.org/10.1158/0008-5472.22404870.v1