Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Frances K. Nally"'
Autor:
Chiara De Santi, Frances K. Nally, Remsha Afzal, Conor P. Duffy, Stephen Fitzsimons, Stephanie L. Annett, Tracy Robson, Jennifer K. Dowling, Sally-Ann Cryan, Claire E. McCoy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 643-655 (2022)
Macrophages are plastic cells playing a crucial role in innate immunity. While fundamental in responding to infections, when persistently maintained in a pro-inflammatory state they can initiate and sustain inflammatory diseases. Therefore, a strateg
Externí odkaz:
https://doaj.org/article/ae3ff2c8f1cd481ead6fd54d5a844dba
Autor:
Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny I. Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory.
Externí odkaz:
https://doaj.org/article/fa68c802cf994295ba5c37913f6eb977
Publikováno v:
Cells, Vol 8, Iss 6, p 543 (2019)
Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Ac
Externí odkaz:
https://doaj.org/article/3b80fba79b694654867e907155cf2a56
Autor:
Fidinny I. Hamid, Gavin P. Davey, Paul J. Hertzog, Conor P. Duffy, Tracy Robson, Daniel J. Gough, Nadine Assmann, Katja Dettmer, Ed C. Lavelle, Christoph Hess, Anne M. Curtis, Bryan R.G. Williams, Frances K. Nally, Aoife L. Gorman, Gavin M. Davis, Claire E. McCoy, Glenn R. Bantug, David K. Finlay, Stephanie Annett, Jennifer K. Dowling, Chiara De Santi, Alex M. Liddicoat, Mariana P. Cervantes-Silva, Remsha Afzal, Peter J. Oefner, Linden J. Gearing
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b0faed67a34997f9e8c7dd17348590
https://www.repository.cam.ac.uk/handle/1810/318448
https://www.repository.cam.ac.uk/handle/1810/318448