Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Frances Joanne Morling"'
Publikováno v:
Journal of Molecular Biology. 285:485-494
We have displayed insulin-like growth factor I (IGF-I) as an N-terminal extension of 4070A (amphotropic) retroviral envelope protein. Western blot demonstrated that chimaeric envelope proteins were incorporated into retroviral particles. Interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8c8cf973a7a09656a56a38724456af4
https://doi.org/10.1006/jmbi.1998.2350
https://doi.org/10.1006/jmbi.1998.2350
Autor:
Marielle Maurice, François-Loïc Cosset, Frances Joanne Morling, Stephen J. Russell, Adele Kay Fielding
Publikováno v:
Blood. 91:1802-1809
We previously reported that retroviral vectors displaying epidermal growth factor (EGF) as part of a chimeric envelope glycoprotein are sequestered upon binding to EGF receptor (EGFR)-positive target cells, leading to loss of infectivity. In the curr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96f01b279c3f6bd65cc7cd2c10ea98f6
https://doi.org/10.1182/blood.v91.5.1802.1802_1802_1809
https://doi.org/10.1182/blood.v91.5.1802.1802_1802_1809
Publikováno v:
Virology. 234(1):51-61
We have constructed chimeric retroviral envelopes displaying N-terminal polypeptides that are known to form homotrimeric associations. The amphotropic receptor (RAM-1) binding domain from the trimeric surface (SU) glycoprotein of 4070A murine leukemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e13aa1b223b30525d7d70e0af6bac4
Retroviral Display of Antibody Fragments; Interdomain Spacing Strongly Influences Vector Infectivity
Autor:
Bo Nilson, S. Ager, Kah Whye Peng, François-Loïc Cosset, Frances Joanne Morling, Stephen J. Russell
Publikováno v:
Human Gene Therapy. 7:2157-2164
Five different single-chain antibody fragments (scFv) against human cell-surface antigens were displayed on murine ecotropic retroviral vectors by fusing them to the Moloney SU envelope glycoprotein. The spacing between the scFv and the SU glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c30711d724e93ae49b1ef879f8b6b4
https://doi.org/10.1089/hum.1996.7.17-2157
https://doi.org/10.1089/hum.1996.7.17-2157
Autor:
Frances Joanne Morling, Yasuhiro Takeuchi, Bo Nilson, Sandrine Valsesia-Wittmann, François-Loïc Cosset, Stephen J. Russell
Publikováno v:
Journal of Virology. 70:2059-2064
We previously reported a strategy to redirect the retroviral host range by expressing single-chain antibodies (S. J. Russell, R. E. Hawkins, and G. Winter, Nucleic Acids Res. 21:1081-1085, 1993) or ligands (F.-L. Cosset, F. J Morling, Y. Takeuchi, R.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fa8743cd97b1db44c655e5b90e49a0
https://doi.org/10.1128/jvi.70.3.2059-2064.1996
https://doi.org/10.1128/jvi.70.3.2059-2064.1996
Autor:
Frances Joanne Morling, Yasuhiro Takeuchi, Mary Collins, Robin A. Weiss, François-Loïc Cosset, Stephen J. Russell
Publikováno v:
Journal of Virology. 69:6314-6322
We have engineered ecotropic Moloney murine leukemia virus-derived envelopes targeted to cell surface molecules expressed on human cells by the N-terminal insertion of polypeptides able to bind either Ram-1 phosphate transporter (the first 208 amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c933c03348e253f48a66cdc720ca81
https://doi.org/10.1128/jvi.69.10.6314-6322.1995
https://doi.org/10.1128/jvi.69.10.6314-6322.1995
Autor:
Frances Joanne Morling, Jie Zhang, Kah Whye Peng, Christian Buchholz, François-Loïc Cosset, Stephen J. Russell
Publikováno v:
Nature biotechnology. 16(10)
Phage display libraries are widely used for selection and optimization of polypeptide ligands or protease substrates. Because they are expressed and amplified in bacterial hosts, phage are not ideal for displaying eukaryotic polypeptides or for probi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43844d05e7ade6bc6ce2f8a992bb435
https://pubmed.ncbi.nlm.nih.gov/9788352
https://pubmed.ncbi.nlm.nih.gov/9788352
Autor:
Kah Whye Peng, Stephen J. Russell, François-Loïc Cosset, Gillian Murphy, Frances Joanne Morling
Publikováno v:
Human gene therapy. 8(6)
We are developing protease-activatable gene delivery vehicles for selective gene delivery to protease-expressing cells. Angiogenesis, inflammation, and cancer invasion are linked to the overexpression of matrix metalloproteinases (MMPs), which destro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6117f1d7e2d00a7972ddb2f9b22e7e14
https://pubmed.ncbi.nlm.nih.gov/9113512
https://pubmed.ncbi.nlm.nih.gov/9113512