Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Frances I. Smith"'
Publikováno v:
European Journal of Neuroscience. 23:2877-2886
The LARGE gene encodes a putative glycosyltransferase that is required for normal glycosylation of dystroglycan, and defects in LARGE can cause abnormal neuronal migration in congenital muscular dystrophy (CMD). Previous studies have focused on radia
Publikováno v:
Journal of Neuroscience Methods. 149:144-153
Cerebellar granule neurons (CGNs) undergo a well-defined, intrinsic differentiation program that is recapitulated in vitro. Thus, homogeneous cultures of CGNs provide an excellent opportunity to define the mechanisms underlying their development. The
Autor:
Qiang Qu, Timothy J. Gilmartin, Seok Jong Hong, Frances I. Smith, Steven R. Head, Kwang-Soo Kim
Publikováno v:
Gene Expression Patterns. 5:740-749
Differences in gene expression patterns between adult and postnatal day 7 (P7) mouse cerebellum, at the peak of granule neuron migration, were analyzed by hybridization to the GLYCOv2 glycogene array. This custom designed oligonucleotide array focuse
Publikováno v:
Journal of Neurochemistry. 90:1389-1401
Receptor for advanced glycation end products (RAGE) has been proposed as a signal transduction receptor to promote neurite outgrowth and cell migration, by its interaction with a neurite outgrowth promoting protein, Amphoterin. Amphoterin has been sh
Autor:
Qiang Qu, Frances I. Smith
Publikováno v:
Journal of Neuroscience Research. 76:771-782
The interaction of alpha-dystroglycan (a-DG) with its extracellular binding partners requires glycans attached to its mucin core domain, and defects in the glycosylation of a-DG are associated with both muscular dystrophy and neuronal migration defec
Autor:
Thia Baboval, Frances I. Smith
Publikováno v:
Mammalian Genome. 13:538-541
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1475:383-389
All mammalian α-1,3-fucosyltransferases (Fuc-Ts) so far characterized have potential N-glycosylation sites, but the role of these sites in enzymatic activity or localization has not been investigated. When one member of this family, rFuc-TIV, is exp
Publikováno v:
Glia. 31:144-154
Glycoconjugates bearing the epitope 3-fucosyl-N-acetyllactosamine (CD15) are believed to be involved in cell-cell interactions and are temporally and spatially regulated in the brain. In the rat postnatal cerebellum, CD15 is predominantly expressed i
Publikováno v:
Journal of Neuroscience Research. 62:206-215
Fucosylated glycoconjugates play an essential role in central nervous system development, but the regulation of expression of these molecules is not well understood. The final biosynthetic step for a major group of cerebellar fucosylated glycoconjuga
Autor:
Jennifer M Aucoin, Omanand Koul, Frances I. Smith, Elizabeth M. Sajdel-Sulkowska, Thia Baboval
Publikováno v:
Glycoconjugate Journal. 15:671-681
Fucosyltransferase (FucT) activity has been detected on the surface of mouse germ cells and rat Sertoli cells, and has been postulated to play a role in cell-cell interactions. A recently cloned rat FucT (rFucT-IV) is expressed in the testes, and thu