Výsledky vyhledávání - "Frances Davenport"

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

Publikováno v: Neuron. 17(5):1005-1013

Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Abeta1-42(43)/Abeta1-40 ratio in the conditioned media of independent N2a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cfbdd42dc011cb37d559eddf05d08d

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Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

Autor: Frances Davenport, Allan I. Levey, Sangram S. Sisodia, Sam Gandy, Mary Seeger, Tamara Ratovitsky, John Hardy, Christer Nordstedt, Lia Spitzer, Nancy A. Jenkins, Hilda H. Slunt, Donald L. Price, David R. Borchelt, Michael K. Lee, Neal G. Copeland, Gopal Thinakaran, Grace Kim

Publikováno v: Neuron. 17:181-190

The majority of early-onset cases of familial Alzheimer's disease (FAD) are linked to mutations in two related genes, PS1 and PS2, located on chromosome 14 and 1, respectively. Using two highly specific antibodies against nonoverlapping epitopes of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c8c94cb724b55113d3523b7032fad2
https://doi.org/10.1016/s0896-6273(00)80291-3

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