Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Frances C Bach"'
Autor:
Thomas Bitterli, David Schmid, Ladina Ettinger, Olga Krupkova, Frances C. Bach, Marianna A. Tryfonidou, Björn P. Meij, Antonio Pozzi, Frank Steffen, Karin Wuertz‐Kozak, Lucas A. Smolders
Publikováno v:
JOR Spine, Vol 7, Iss 1, Pp n/a-n/a (2024)
Abstract Background The regulation of inflammatory mediators in the degenerating intervertebral disc (IVD) and corresponding ligamentum flavum (LF) is a topic of emerging interest. The study aimed to investigate the expression of a broad array of inf
Externí odkaz:
https://doaj.org/article/a0130bc574964e6baf2eee7b83f54b28
Autor:
Jie Du, João P. Garcia, Frances C. Bach, Anna R. Tellegen, Sibylle Grad, Zhen Li, René M. Castelein, Björn P. Meij, Marianna A. Tryfonidou, Laura B. Creemers
Publikováno v:
Journal of Orthopaedic Translation, Vol 37, Iss , Pp 23-36 (2022)
Background: Intervertebral disc (IVD) degeneration is suggested as a major cause of chronic low back pain (LBP). Intradiscal delivery of growth factors has been proposed as a promising strategy for IVD repair and regeneration. Previously, BMP-4 was s
Externí odkaz:
https://doaj.org/article/850513532fae49d98f7ddb56266e7ac3
Autor:
Martijn Beukers, Guy C. M. Grinwis, Johannes C. M. Vernooij, Lisanne van derHoek, Anna R. Tellegen, Björn P. Meij, Stefanie Veraa, Dino Samartzis, Marianna A. Tryfonidou, Frances C. Bach
Publikováno v:
JOR Spine, Vol 6, Iss 3, Pp n/a-n/a (2023)
Abstract Background Chronic low back pain, a leading contributor to disease burden worldwide, is often caused by intervertebral disc (IVD) degeneration. Modic changes (MCs) are MRI signal intensity changes due to lesions in vertebral bone marrow adja
Externí odkaz:
https://doaj.org/article/fb5d475e0b13418d8d7f2ea7a5d5e74d
Autor:
Rebecca J. Williams, Lisanne T. Laagland, Frances C. Bach, Lizzy Ward, Wilson Chan, Vivian Tam, Adel Medzikovic, Shaghayegh Basatvat, Lily Paillat, Nicolas Vedrenne, Joseph W. Snuggs, Deepani W. Poramba‐Liyanage, Judith A. Hoyland, Danny Chan, Anne Camus, Stephen M. Richardson, Marianna A. Tryfonidou, Christine L. Le Maitre
Publikováno v:
JOR Spine, Vol 6, Iss 3, Pp n/a-n/a (2023)
Abstract Background Lineage‐tracing experiments have established that the central region of the mature intervertebral disc, the nucleus pulposus (NP), develops from the embryonic structure called “the notochord”. However, changes in the cells d
Externí odkaz:
https://doaj.org/article/dfa01fb81efe46eab3be07a579ca5024
Autor:
Shaghayegh Basatvat, Frances C. Bach, Marcos N. Barcellona, Abbie L. Binch, Conor T. Buckley, Brian Bueno, Nadeen O. Chahine, Ana Chee, Laura B. Creemers, Stefan Dudli, Bailey Fearing, Stephen J. Ferguson, Jennifer Gansau, Benjamin Gantenbein, Rahul Gawri, Juliane D. Glaeser, Sibylle Grad, Julien Guerrero, Lisbet Haglund, Paula A. Hernandez, Judith A. Hoyland, Charles Huang, James C. Iatridis, Svenja Illien‐Junger, Liufang Jing, Petra Kraus, Lisanne T. Laagland, Gernot Lang, Victor Leung, Zhen Li, Thomas Lufkin, Josette C. vanMaanen, Emily E. McDonnell, Chris J. Panebianco, Steven M. Presciutti, Sanjna Rao, Stephen M. Richardson, Sarah Romereim, Tara C. Schmitz, Jordy Schol, Lori Setton, Dmitriy Sheyn, Joseph W. Snuggs, Y. Sun, Xiaohong Tan, Marianna A. Tryfonidou, Nam Vo, Dong Wang, Brandon Williams, Rebecca Williams, S. Tim Yoon, Christine L. Le Maitre
Publikováno v:
JOR Spine, Vol 6, Iss 1, Pp n/a-n/a (2023)
Abstract Background In vitro studies using nucleus pulposus (NP) cells are commonly used to investigate disc cell biology and pathogenesis, or to aid in the development of new therapies. However, lab‐to‐lab variability jeopardizes the much‐need
Externí odkaz:
https://doaj.org/article/4cf7143b0ac5450a9e437e4c96e1d1cf
Autor:
Lisanne T. Laagland, Frances C. Bach, Laura B. Creemers, Christine L. Le Maitre, Deepani W. Poramba‐Liyanage, Marianna A. Tryfonidou
Publikováno v:
JOR Spine, Vol 5, Iss 3, Pp n/a-n/a (2022)
Abstract Background Repopulating the degenerated intervertebral disc (IVD) with tissue‐specific nucleus pulposus cells (NPCs) has already been shown to promote regeneration in various species. Yet the applicability of NPCs as cell‐based therapy h
Externí odkaz:
https://doaj.org/article/74873276124d4d7da3574e58ef5e9da1
Autor:
Frances C. Bach, Deepani W. Poramba-Liyanage, Frank M. Riemers, Jerome Guicheux, Anne Camus, James C. Iatridis, Danny Chan, Keita Ito, Christine L. Le Maitre, Marianna A. Tryfonidou
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Chronic low back pain is the number one cause of years lived with disability. In about 40% of patients, chronic lower back pain is related to intervertebral disc (IVD) degeneration. The standard-of-care focuses on symptomatic relief, while surgery is
Externí odkaz:
https://doaj.org/article/125dce31a73e491a8a4a2d2dfcc3743b
Autor:
Naomi N. Lee, Elias Salzer, Frances C. Bach, Andres F. Bonilla, James L. Cook, Zulma Gazit, Sibylle Grad, Keita Ito, Lachlan J. Smith, Andrea Vernengo, Hans‐Joachim Wilke, Julie B. Engiles, Marianna A. Tryfonidou
Publikováno v:
JOR Spine, Vol 4, Iss 2, Pp n/a-n/a (2021)
Abstract Preclinical studies involving large animal models aim to recapitulate the clinical situation as much as possible and bridge the gap from benchtop to bedside. To date, studies investigating intervertebral disc (IVD) degeneration and regenerat
Externí odkaz:
https://doaj.org/article/ee8b289103d74341b34da54f71abb462
Autor:
Frances C. Bach, Kim M. deRooij, Frank M. Riemers, Joseph W. Snuggs, Willem A. M. deJong, Ying Zhang, Laura B. Creemers, Danny Chan, Christine Le Maitre, Marianna A. Tryfonidou
Publikováno v:
JOR Spine, Vol 2, Iss 4, Pp n/a-n/a (2019)
Abstract Parathyroid hormone‐related protein (PTHrP) and hedgehog signaling play an important role in chondrocyte development, (hypertrophic) differentiation, and/or calcification, but their role in intervertebral disc (IVD) degeneration is unknown
Externí odkaz:
https://doaj.org/article/510a3865d7fe42aa8c2b4d06a65a56af
Autor:
Joseph W. Snuggs, Rebecca E. Day, Frances C. Bach, Matthew T. Conner, Rowena A. D. Bunning, Marianna A. Tryfonidou, Christine L. Le Maitre
Publikováno v:
JOR Spine, Vol 2, Iss 1, Pp n/a-n/a (2019)
The intervertebral disc (IVD) is a highly hydrated tissue, the rich proteoglycan matrix imbibes water, enabling the disc to withstand compressive loads. During aging and degeneration increased matrix degradation leads to dehydration and loss of funct
Externí odkaz:
https://doaj.org/article/82fd417e5f5849c199690598af709585