NK cells limit therapeutic vaccine–induced CD8+T cell immunity in a PD-L1–dependent manner

Autor: Mariana O. Diniz, Anna Schurich, Senthil K. Chinnakannan, Marion Duriez, Kerstin A. Stegmann, Jessica Davies, Stephanie Kucykowicz, Kornelija Suveizdyte, Oliver E. Amin, Frances Alcock, Tamsin Cargill, Eleanor Barnes, Mala K. Maini

Publikováno v: Diniz, M O, Schurich, A, Chinnakannan, S K, Duriez, M, Stegmann, K A, Davies, J, Kucykowicz, S, Suveizdyte, K, Amin, O E, Alcock, F, Cargill, T, Barnes, E & Maini, M K 2022, ' NK cells limit therapeutic vaccine–induced CD8 + T cell immunity in a PD-L1–dependent manner ', Science Translational Medicine, vol. 14, no. 640, eabi4670 . https://doi.org/10.1126/scitranslmed.abi4670

A better understanding of mechanisms that regulate CD8 + T cell responses to therapeutic vaccines is needed to develop approaches to enhance vaccine efficacy for chronic viral infections and cancers. We show here that NK cell depletion enhanced antig

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https://kclpure.kcl.ac.uk/ws/files/175375334/NK_cells_limit_therapeutic_DINIZ_Publishedonline13April2022_GREEN_AAM.pdf