Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Frances A. Lemckert"'
Autor:
Joe Yasa, Claudia E. Reed, Adam M. Bournazos, Frances J. Evesson, Ignatius Pang, Mark E. Graham, Jesse R. Wark, Brunda Nijagal, Kim H. Kwan, Thomas Kwiatkowski, Rachel Jung, Noah Weisleder, Sandra T. Cooper, Frances A. Lemckert
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-16 (2023)
Abstract Dysferlin is a Ca2+-activated lipid binding protein implicated in muscle membrane repair. Recessive variants in DYSF result in dysferlinopathy, a progressive muscular dystrophy. We showed previously that calpain cleavage within a motif encod
Externí odkaz:
https://doaj.org/article/6b549e68706942818cd58183122bbf7a
Autor:
Ann-Katrin Piper, Reece A. Sophocleous, Frances A. Lemckert, Joe Yasa, Ronald Sluyter, Samuel E. Ross, Maté Biro, Peter A. Greer, Claudia Reed, Natalie Woolger, Adam Bournazos, Omar Saleh, Frances J. Evesson, Sandra T. Cooper
Publikováno v:
American journal of physiology. Cell physiology. 318(6)
The ubiquitous calpains, calpain-1 and -2, play important roles in Ca2+-dependent membrane repair. Mechanically active tissues like skeletal muscle are particularly reliant on mechanisms to repair and remodel membrane injury, such as those caused by
Autor:
Ann-Katrin Piper, Natalie Woolger, Peter A. Greer, Roger Bryan Sutton, Samuel E. Ross, Sandra T. Cooper, Adam Bournazos, Gregory M. I. Redpath, Frances A. Lemckert
Publikováno v:
Cellular Signalling. 33:30-40
Myoferlin and dysferlin are closely related members of the ferlin family of Ca2+-regulated vesicle fusion proteins. Dysferlin is proposed to play a role in Ca2+-triggered vesicle fusion during membrane repair. Myoferlin regulates endocytosis, recycli
Autor:
Gregory M. I. Redpath, Ann-Katrin Lueders, Cynthia B. Whitchurch, Angela Lek, Frances A. Lemckert, Frances J. Evesson, Lynne Turnbull, Kathryn N. North, Sandra T. Cooper
Publikováno v:
The Journal of Neuroscience. 33:5085-5094
Dysferlin is proposed as a key mediator of calcium-dependent muscle membrane repair, although its precise role has remained elusive. Dysferlin interacts with a new membrane repair protein, mitsugumin 53 (MG53), an E3 ubiquitin ligase that shows rapid
Autor:
Frances J. Evesson, J. Hawkes, Noah Weisleder, Michael J. Ackerman, Nigel F. Clarke, Frances A. Lemckert, Angela Lek, Neil E. Street, Sandra T. Cooper, Xi F. Zheng, Leigh B. Waddell, Jenny Tran, Jianjie Ma, Kathryn N. North, Andrew P. Landstrom, Pei-Hui Lin
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 70:302-313
Mutations in dysferlin cause an inherited muscular dystrophy because of defective membrane repair. Three interacting partners of dysferlin are also implicated in membrane resealing: caveolin-3 (in limb girdle muscular dystrophy type 1C), annexin A1,
Autor:
Galina Schevzov, Patrick P.L. Tam, Poh-Lynn Khoo, Jeff Hook, Catherine M. Watson, Yee-Ka Agnes Chan, Thomas Fath, Peter W. Gunning, Bernadette Vrhovski, Nikki M. Curthoys, Hamish Clarke, Frances A. Lemckert
Publikováno v:
European Journal of Cell Biology. 89:489-498
Previous studies have shown that the overexpression of tropomyosins leads to isoform-specific alterations in the morphology of subcellular compartments in neuronal cells. Here we have examined the role of the most abundant set of isoforms from the ga
Autor:
Sara J. Bontempo, Edna C. Hardeman, Enoch S. E. Tay, Peter W. Gunning, Frances A. Lemckert, Nicole Santucci, Jocelyn Widagdo, Kylie M. Taylor, Stephen J. Palmer, Jeff Hook
Publikováno v:
Journal of Biological Chemistry. 285:4715-4724
The GTF2IRD1 gene is of principal interest to the study of Williams-Beuren syndrome (WBS). This neurodevelopmental disorder results from the hemizygous deletion of a region of chromosome 7q11.23 containing 28 genes including GTF2IRD1. WBS is thought
Autor:
David G. Little, Frances A. Lemckert, Mai-Anh Nguyen, Roger R. Reddel, Edna C. Hardeman, Peter W. Gunning, Michelle M. McDonald, Jeff Hook, Andy C.-M. Chang
Publikováno v:
Endocrinology. 149:2403-2410
Stanniocalcin (STC), a secreted glycoprotein, was first studied in fish as a classical hormone with a role in regulating serum calcium levels. There are two closely related proteins in mammals, STC1 and STC2, with functions that are currently unclear
Autor:
Frances A. Lemckert, Josephine E. Joya, Bernadette Vrhovski, Franz Puttur, David F. Wieczorek, Sudarsan Rajan, Geraldine M. O'Neill, Galina Schevzov, Thomas Fath, Peter W. Gunning, Jim J.-C. Lin, Edna C. Hardeman, Nicole Vlahovich, Jeff Hook
Publikováno v:
Journal of Biological Chemistry. 283:275-283
The existence of a feedback mechanism regulating the precise amounts of muscle structural proteins, such as actin and the actin-associated protein tropomyosin (Tm), in the sarcomeres of striated muscles is well established. However, the regulation of
Autor:
J. Hawkes, Sandra T. Cooper, Kathryn N. North, Adam Bournazos, Frances A. Lemckert, Daniel M. Eckert, Tanya L. Butler, Manuel Kenzler, David S. Winlaw, Bradley Ceely, Jonathan R. Egan
Publikováno v:
Cardiovascular research. 110(2)
Aims Mitsugumin-53 (MG53/TRIM72) is an E3-ubiquitin ligase that rapidly accumulates at sites of membrane injury and plays an important role in membrane repair of skeletal and cardiac muscle. MG53 has been implicated in cardiac ischaemia–reperfusion