Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Frances Donahue"'
Autor:
Megan A. Foley, M. Sherry Ku, Cheryl Nickerson-Nutter, Lihren Chen, Weiheng Wang, Manjunath K. Ramarao, Marina W.H. Shen, Debra G. Goodwin, Katherine L. Lee, Tam Steve Yik-Kai, Jaechul Shim, Mark L. Behnke, SooPeang Khor, John C. McKew, Xin Xu, Steven J. Kirincich, Frank Lovering, Frances Donahue, James D. Clark
Publikováno v:
Journal of Medicinal Chemistry. 50:1380-1400
The synthesis and structure-activity relationship of a series of indole inhibitors of cytosolic phospholipase A2alpha (cPLA2alpha, type IVA phospholipase) are described. Inhibitors of cPLA2alpha are predicted to be efficacious in treating asthma as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f309b58c1ad34e2e7e4cbf67afce20
https://doi.org/10.1021/jm061131z
https://doi.org/10.1021/jm061131z
Autor:
Manus Ipek, Cheryl L. Nickerson-Nutter, Marina W.H. Shen, Elizabeth A. Murphy, Martin Hegen, Cara Williams, Kun Wu, James C. Keith, Baihua Hu, Steven J. Kirincich, Paresh Thakker, Ronald S Michalak, Katherine L. Lee, John C. McKew, James D. Clark, Leo Albert, Steve Tam, Lihren Chen, Manjunath K. Ramarao, Yonghan Hu, Debra G. Goodwin, Xin Xu, Sum Fuk-Wah, Mark L. Behnke, Frances Donahue, Megan A. Foley, M. Sherry Ku, Jennifer Thomason, William M. Abraham, Lane Wooder
Publikováno v:
Journal of medicinal chemistry. 51(12)
The optimization of a class of indole cPLA 2 alpha inhibitors is described herein. The importance of the substituent at C3 and the substitution pattern of the phenylmethane sulfonamide region are highlighted. Optimization of these regions led to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d0ce05d3b971757ea8be4ba47a741f
https://pubmed.ncbi.nlm.nih.gov/18498150
https://pubmed.ncbi.nlm.nih.gov/18498150
Autor:
Katherine L. Lee, Megan A. Foley, Lihren Chen, Mark L. Behnke, Frank E. Lovering, Steven J. Kirincich, Weiheng Wang, Jaechul Shim, Steve Tam, Marina W. H. Shen, SooPeang Khor, Xin Xu, Debra G. Goodwin, Manjunath K. Ramarao, Cheryl Nickerson-Nutter, Frances Donahue, M. Sherry Ku, James D. Clark, John C. McKew
Publikováno v:
Journal of Medicinal Chemistry; Mar2007, Vol. 50 Issue 6, p1380-1400, 21p