Výsledky vyhledávání - "Frances‐Rose Schumacher"

Akademický článek

Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W

Autor: Christopher W. Davies, Simon E. Vidal, Lilian Phu, Jawahar Sudhamsu, Trent B. Hinkle, Scott Chan Rosenberg, Frances-Rose Schumacher, Yi Jimmy Zeng, Carsten Schwerdtfeger, Andrew S. Peterson, Jennie R. Lill, Christopher M. Rose, Andrey S. Shaw, Ingrid E. Wertz, Donald S. Kirkpatrick, James T. Koerber

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

UBE2W catalyzes the ubiquitination of protein N-termini but its substrate spectrum is largely unknown. Here, the authors discover mAbs selective for peptides derived from N-terminally ubiquitinated proteins, solve the structure of a peptide-bound mAb

Externí odkaz: https://doaj.org/article/cbfb2674260f4b51a1c495c83e07dcb5

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Akademický článek

Characterisation of the Cullin‐3 mutation that causes a severe form of familial hypertension and hyperkalaemia

Autor: Frances‐Rose Schumacher, Keith Siew, Jinwei Zhang, Clare Johnson, Nicola Wood, Sarah E Cleary, Raya S Al Maskari, James T Ferryman, Iris Hardege, Yasmin, Nichola L Figg, Radoslav Enchev, Axel Knebel, Kevin M O'Shaughnessy, Thimo Kurz

Publikováno v: EMBO Molecular Medicine, Vol 7, Iss 10, Pp 1285-1306 (2015)

Abstract Deletion of exon 9 from Cullin‐3 (CUL3, residues 403–459: CUL3Δ403–459) causes pseudohypoaldosteronism type IIE (PHA2E), a severe form of familial hyperkalaemia and hypertension (FHHt). CUL3 binds the RING protein RBX1 and various sub

Externí odkaz: https://doaj.org/article/b8eca7c013e14608b210eecae1e9004c

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Akademický článek

RNAi Screen for NRF2 Inducers Identifies Targets That Rescue Primary Lung Epithelial Cells from Cigarette Smoke Induced Radical Stress.

Autor: Frances-Rose Schumacher, Steffen Schubert, Michael Hannus, Birte Sönnichsen, Carina Ittrich, Stefan Kreideweiss, Thimo Kurz, Jörg F Rippmann

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0166352 (2016)

Chronic Obstructive Pulmonary Disease (COPD) is a highly prevalent condition characterized by inflammation and progressive obstruction of the airways. At present, there is no treatment that suppresses the chronic inflammation of the disease, and COPD

Externí odkaz: https://doaj.org/article/3e5f09faa6d9494c897c11eb49c84150

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Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W

Autor: Scott C. Rosenberg, James T. Koerber, Christopher M. Rose, Donald S. Kirkpatrick, Simon E. Vidal, Andrey S. Shaw, Ingrid E. Wertz, Trent Hinkle, Lilian Phu, Frances-Rose Schumacher, Andrew S. Peterson, Yi Zeng, Carsten Schwerdtfeger, Jennie R. Lill, Jawahar Sudhamsu, Christopher W. Davies

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

The ubiquitin conjugating enzyme UBE2W catalyzes non-canonical ubiquitination on the N-termini of proteins, although its substrate repertoire remains unclear. To identify endogenous N-terminally-ubiquitinated substrates, we discover four monoclonal a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b757adebe34eddabcce93c96eb9cad9c
http://europepmc.org/articles/PMC8322077

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Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia

Autor: Iris Hardege, Radoslav I. Enchev, Yasmin, Nicola T. Wood, Nichola Figg, Clare Johnson, S Cleary, James T Ferryman, Jinwei Zhang, Thimo Kurz, Keith Siew, Raya Al Maskari, Kevin M. O'Shaughnessy, Axel Knebel, Frances-Rose Schumacher

Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, 7 (10)

Deletion of exon 9 from Cullin‐3 (CUL3, residues 403–459: CUL3Δ403–459) causes pseudohypoaldosteronism type IIE (PHA2E), a severe form of familial hyperkalaemia and hypertension (FHHt). CUL3 binds the RING protein RBX1 and various substrate ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523b772e8c9474816752922c62f8b2d0
http://europepmc.org/articles/PMC4604684

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The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Autor: Thomas Macartney, Youcef Mehellou, Frances-Rose Schumacher, Axel Knebel, Akihito Ohta, Dario R. Alessi, Nicola T. Wood, Clare Johnson, Thimo Kurz

Publikováno v: Biochemical Journal

The WNK (with no lysine kinase)–SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an important role in controlling mammalian blood pressure by modulating the activity of ion co-tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070788786abe18caa6db90ba6b935486
https://doi.org/10.1042/bj20121903

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RNAi Screen for NRF2 Inducers Identifies Targets That Rescue Primary Lung Epithelial Cells from Cigarette Smoke Induced Radical Stress

Autor: Stefan Kreideweiss, Birte Sönnichsen, Frances-Rose Schumacher, Steffen Schubert, Jörg F. Rippmann, Michael Hannus, Thimo Kurz, Carina Ittrich

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 11, p e0166352 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82618a5a7b7d69cb33d19a7b576402b9
http://europepmc.org/articles/PMC5104413

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Building proteomic tool boxes to monitor MHC class I and class II peptides

Autor: Lélia Delamarre, Jennie R. Lill, Zora Modrusan, Joshua E. Elias, Qui T. Phung, Frances-Rose Schumacher, Suchit Jhunjhunwala

Publikováno v: PROTEOMICS. 17:1600061

Major histocompatibility complex Class I (MHCI) and Class II (MHCII) presented peptides powerfully modulate T cell immunity and play a vital role in generating effective anti-tumor and anti-viral immune responses in mammals. Characterizing these MHCI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a987fc8fb5e66ffdbf4b14ccf625caab
https://doi.org/10.1002/pmic.201600061

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