Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Frances, Willenbrock"'
Publikováno v:
Current Oncology, Vol 29, Iss 4, Pp 2516-2529 (2022)
Surgical resection remains the only curative treatment strategy for Pancreatic Ductal Adenocarcinoma (PDAC). A proportion of patients succumb to early disease recurrence post-operatively despite receiving adjuvant chemotherapy. The ability to identif
Externí odkaz:
https://doaj.org/article/7784b4f3a6fc440ca73e4c24d9cbf7b5
Autor:
Daniel Hughes, Frances Willenbrock, Srikanth Reddy, Venkatesha Udupa, Michael Silva, Zahir Soonawalla, Somnath Mukerjee, Eric O'Neill
Publikováno v:
British Journal of Surgery. 109
Background A significant variation is observed in the response rate to chemotherapy amongst patients with pancreatic cancer. Current guidelines advocate treatment regimes based purely on the patient's level of fitness. Such an approach fails to ackno
Autor:
Philip Earwaker, Caroline Anderson, Frances Willenbrock, Adrian L Harris, Andrew S Protheroe, Valentine M Macaulay
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191890 (2018)
The outlook for patients with advanced renal cell cancer (RCC) has been improved by targeted agents including inhibitors of the PI3 kinase (PI3K)-AKT-mTOR axis, although treatment resistance is a major problem. Here, we aimed to understand how RCC ce
Externí odkaz:
https://doaj.org/article/a518e79ae27440dca778a61503dee383
Autor:
Christopher M. Jones, Ahmad Sabbagh, Somnath Mukherjee, Daniel Hughes, Robert Owens, Frances Willenbrock, Tim Maughan, Catrin Cox, Eileen Parkes, Eric O'Neill, Charlotte Wilhelm-Benartzi, Chris Nicholas Hurt, Aswin George Abraham
Publikováno v:
British Journal of Cancer
Background The Phase 2 SCALOP trial compared gemcitabine with capecitabine-based consolidation chemoradiotherapy (CRT) in locally advanced pancreatic cancer (LAPC). Methods Thirty-five systematically identified circulating biomarkers were analysed in
Autor:
Mark R. Middleton, Anthony Cutts, Alan Sharpe, L Collins, Roz Brant, Darren Hodgson, Frances Willenbrock, Kevin Alan Myers, Ruth Asher, Adelyn Wise, Sharon Love, Anna Schuh, Avinash Gupta, Valentine M. Macaulay, Christopher Towers, Paul D. Smith
Publikováno v:
British Journal of Cancer
Background Aiming to improve treatment options for BRAF wild-type melanoma, we previously conducted the DOC-MEK study of docetaxel with MEK inhibitor (MEKi) selumetinib or placebo, revealing trends to prolongation of progression-free survival (hazard
Autor:
Vassilis G. Gorgoulis, Eric O'Neill, Zoi Lygerou, Frances Willenbrock, Maria Chatzifrangkeskou, Stavroula Tsaridou, Georgia Velimezi, Andreas Panagopoulos, Dimitris Karamitros, Dafni-Eleftheria Pefani
DNA lesions occur across the genome and constitute a threat to cell viability; however, damage at specific genomic loci has a disproportionally greater impact on the overall genome stability. The ribosomal RNA gene repeats (rDNA) are emerging fragile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::459f0e6b09fc398b6b8f2e422780621c
https://doi.org/10.1101/2021.11.17.469058
https://doi.org/10.1101/2021.11.17.469058
Autor:
Asmita Thapa, Simone Landfredini, Andrew Blake, Stephanie Jones, Daniel S.T. Hughes, Clare Verrill, Adam Burns, Robert D. Goldin, Michael Eyres, Zahir Soonawalla, Anna Schuh, Eric O'Neill, Christine Blancher, Aswin George Abraham, Ahmad Sabbagh, Michael Silva, Tim Maughan, Frances Willenbrock, Aline Hubert, S. M. Hughes, Somnath Mukherjee, Zenobia D’Costa, Dimitris Vavoulis
Background and AimsPancreatic ductal adenocarcinoma (PDAC) is characterised by advanced disease stage at presentation, aggressive disease biology and resistance to therapy resulting in extremely poor five-year survival MethodsGenome-wide epigenetic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e84ed9419a2ec19a587aea04fea3f8c3
https://doi.org/10.1101/2020.10.22.342436
https://doi.org/10.1101/2020.10.22.342436
Autor:
Michael Eyres, Christine Blancher, Andrew Blake, Frances Willenbrock, Dimitris Vavoulis, Michael Silva, Zahir Soonawalla, Daniel S.T. Hughes, Aswin George Abraham, Haonan Xu, Stephanie Jones, Asmita Thapa, S. M. Hughes, Robert D. Goldin, Eric O'Neill, Anna Schuh, Ahmad Sabbagh, Adam Burns, Simone Lanfredini, Clare Verrill, Somnath Mukherjee, Zenobia D’Costa, Tim Maughan, Aline Hubert
Publikováno v:
668.e16
BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is characterized by advanced disease stage at presentation, aggressive disease biology, and resistance to therapy, resulting in an extremely poor 5-year survival rate of
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38517 (2012)
The role of Gαi proteins coupled to chemokine receptors in directed migration of immune cells is well understood. In this study we show that the separate class of Gαq/11 proteins is required for the underlying ability of T cells to migrate both ran
Externí odkaz:
https://doaj.org/article/1d4ad37161ce4e5cbc5f3b19222123c5
Autor:
Simone Lanfredini, Somnath Mukherjee, Frances Willenbrock, Asmita Thapa, Charlotte Wilhelm-Benartzi, S. M. Hughes, Fiona Bangs, Eric O'Neill, Catrin Cox, Chris Nicholas Hurt, Aswin George Abraham, A Sabbagh, Tim Maughan, R Owens
Publikováno v:
Journal of Clinical Oncology. 38:740-740
740 Background: SCALOP was a multi-centre phase II RCT where 114 patients with LAPC were received 3 cycles of Gemcitabine and Capecitabine (GEMCAP) and those with stable/responding disease (n = 74) were randomised to Gem-RT or Cap-RT. The trial showe